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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Journal of Molecular Pathology

Discrepancies in the Molecular Epidemiology of Druggable Genetic Alterations in Non-Small Cell Lung Cancer

Panagiotis Paliogiannis, Angelo Zinellu, Giuseppe Palmieri, Alessandro Giuseppe Fois

Non-small cell lung cancer (NSCLC) represents most lung cancer diagnoses worldwide and remains a leading cause of cancer-related mortality. The advent of precision oncology has transformed the therapeutic landscape of NSCLC through the identification of druggable genetic alterations, enabling the use of targeted therapies with significant clinical benefit. However, the reported prevalence of these alterations varies widely across studies and populations, raising important questions about the underlying determinants …

27.08.2026journal-article

Frontiers in Global Women's Health

Expanding treatment options for syphilis during pregnancy: a review of alternatives to penicillin

Claire L. Townsend, Lynne Mofenson, Sami Gottlieb, Remco P. H. Peters, Oriol Mitjà, Clara Pérez-Mañá, Elaine J. Abrams, Sinead Delany-Moretlwe, Shahin Lockman, Catriona Waitt, Kathryn Miele, Melanie M. Taylor, Françoise Renaud

Syphilis infection during pregnancy leads to around 390,000 adverse birth outcomes each year and is an important cause of preventable stillbirth. Although benzathine penicillin G is safe and effective during pregnancy for treating maternal and fetal infection, there are frequent global shortages and limited options for people with penicillin allergy. We conducted a review of potential alternatives to penicillin for treating syphilis during pregnancy when penicillin is not available or cannot be used, including ceft …

27.08.2026journal-article

BMC Genomics

Genomic epidemiology, population structure and lineage-associated genomic variation in KPC-producing Pseudomonas aeruginosa

Tianci Zhou, Ni Li, Jingjie Li, Mingxiao Chen, Youqiang Li

Abstract Objectives KPC-producing Pseudomonas aeruginosa (KPC-PA) has emerged as an important multidrug-resistant pathogen, yet its population structure and lineage-associated genomic variation remain incompletely understood. We investigated the genomic epidemiology of an international collection of KPC-PA genomes to characterize population structure, evolutionary patterns, and lineage-associated genomic features. Methods A complete genome of a clinical ST463 isolate (PA328) was generated using hybrid sequencing an …

27.08.2026journal-article

Designs

A Health Belief Model- and TRIZ-Based Design Method for Transfer Assistive Equipment for Individuals with Lower-Limb Mobility Impairment

Haiqiang Wang, Jiali Deng, Xuan Huang, Yexin Chen

Individuals with lower-limb mobility impairment often experience fear of falling and difficulty coordinating with caregivers during transfer tasks. Therefore, safe, stable, and easy-to-operate collaborative transfer assistive equipment is urgently needed. This study proposes a Health Belief Model-driven design method for transfer assistive equipment, aiming to translate users’ risk perceptions and behavioral needs into implementable structural design strategies. First, transfer-related behavioral characteristics we …

27.08.2026journal-article

Health Research Journal of Indonesia

Analisis Bentuk Pemborosan Pada Manajemen Logistik Medis Di Instalasi Farmasi Rumah Sakit Surabaya

Diva Faradiba, Afif Kurniawan, Yura Witsqa Firmansyah, Firnanda Erindia

Manajemen logistik medis berperan penting dalam menjamin ketersediaan obat, alat kesehatan, dan bahan medis habis pakai di rumah sakit. Pengelolaan logistik yang belum optimal dapat menimbulkan pemborosan (waste) sehingga menurunkan efisiensi operasional dan mutu pelayanan. Penelitian ini bertujuan menganalisis bentuk pemborosan pada manajemen logistik medis di Instalasi Farmasi Rumah Sakit Surabaya menggunakan pendekatan Lean Hospital berdasarkan konsep Seven Wastes. Penelitian menggunakan metode kualitatif dengan …

27.08.2026journal-article

Health Research Journal of Indonesia

Evaluasi Implementasi Program Kesehatan Kerja pada Area Workshop dan Perkantoran di PT X

Reza Maria Nainggolan, Muhammad Jenar Susanto, Nico Linggi Pongmasangka

Program kesehatan kerja merupakan kewajiban perusahaan untuk melindungi dan meningkatkan derajat kesehatan pekerja sesuai dengan ketentuan PP No. 28 Tahun 2024 dan Permenaker No. 5 Tahun 2018. Penelitian ini bertujuan mengevaluasi implementasi program kesehatan kerja pada perusahaan layanan pemeliharaan ketenagalistrikan di Jakarta Timur. Penelitian menggunakan metode deskriptif kualitatif melalui observasi lapangan, wawancara dengan pekerja, serta telaah data sekunder hasil pengukuran lingkungan kerja. Hasil penel …

27.08.2026journal-article

Journal of the American Heart Association

Multidisciplinary Heart Team Model to Deliver Advanced Cardiovascular Care in a Public Safety‐Net Hospital

Emily K. Zern, Soham Rege, Isaac Gorgy, Wilson Tang, Parth P. Patel, Kelley Benck, Eric D. Lucas, Adriana Shen, Henry Steyer, Imam Sanousi, Brandon B. Ge, Ben A. Lin, Samuel S. Gordon, Christopher Justino, Diane Do, Nicole C. Zamora, Maxine Stachel, Sanjeet Patel, Ivana Nikolic, Alayn Govea, Helga Van Herle, Serge Kobsa, Rachel Baden, Brad Spellberg, Anilkumar Mehra, Brandon M. Wiley

Background Implementation of guideline‐supported Multidisciplinary Heart Teams (MHT) for the management of complex cardiovascular disease has not been described in a public safety‐net hospital setting. In May 2023, an MHT was established at Los Angeles General Medical Center to deliver comprehensive cardiovascular care to an underserved population in a resource‐constrained setting. Methods We conducted a retrospective review of all cases discussed by a comprehensive MHT at Los Angeles General Medical Center from Ma …

27.08.2026journal-article

Journal of Central Banking Theory and Practice

Time-Varying Impacts of Structural Oil Price Shocks on Economic Policy Uncertainty in China: The Role of a Hybrid Monetary Policy Tools Framework

Zhang Mengdi, Lee Chin, W.N.W. Azman Saini

Abstract This paper examines the time-varying responses of China’s economic policy uncertainty (EPU) to five structural oil-price shocks, with particular attention to the responses of price- and quantity-based monetary policy instruments. Using quarterly data from 2007Q2 to 2025Q1, we estimate a TVP-VAR-SV model that incorporates both the interest rate gap and the money supply gap to capture the coexistence of price- and quantity-based policy tools in China. The results show that only aggregate supply shocks elicit …

27.08.2026journal-article

BMC Public Health

Association between visits to blue spaces within walking distance and mental health among older adults in Japan: a cross-sectional study from the Japan Gerontological Evaluation Study

Kazuki Matsumoto, Yu-Ru Chen, Yoko Matsuoka, Hiroaki Yoshida, Atsushi Nakagomi, Katsunori Kondo, Masamichi Hanazato

Abstract Background Exposure to blue spaces has been associated with better mental health, but most studies have focused on environmental proximity rather than actual use (frequency of visits and activity types) and have been conducted in Western countries. Evidence among older adults in Asian settings remains limited. This study examined the associations between frequency of visits to blue spaces within walking distance, activity types performed there, and mental health among older adults using data from 69 munici …

27.08.2026journal-article

Frontiers in Public Health

Prevalence and factors of frailty among community-dwelling older adults: a multimorbidity perspective

Shubing Feng, Pengpeng Wang, Hongxia Huang, Zhenhong Lin, Yuanhang Liu

Background Frailty is a geriatric syndrome that reduces quality of life and increases social burden. Existing frailty research predominantly focuses on hospitalized or nursing home-residing older adults, while surveys targeting community-dwelling older adults with multimorbidity remain scarce. Objective To investigate the prevalence and influencing factors of frailty among community-dwelling older adults with multimorbidity. Methods A cross-sectional survey was conducted from May to November 2025. Convenience sampl …

27.08.2026journal-article

Sports Health: A Multidisciplinary Approach

The Effect of Stud Flexibility on Lower Limb Biomechanical Demands in Football-Specific Movements

Gabriele Azzolini, Silvia Fantozzi, Andrea Ferretti, Ezio Preatoni

Background: Stud design is critical in modulating impact forces between football boot and turf, yet most systems prioritize traction using rigid materials, largely neglecting the role of material flexibility in load attenuation. This study assessed the biomechanical effects of 2 novel flexible stud designs compared with a traditional rigid stud during football-specific cutting and landing tasks. Hypothesis: Replacing traditional rigid studs with more flexible alternatives would reduce the magnitude and increase the …

27.08.2026journal-article

PLOS Global Public Health

Mental health status and its associated factors among women with fertility issues visiting fertility center in Kathmandu Valley: A cross-sectional study

Pragya Kunwar, Amrita Ghimire, Aakriti Bharati, Amrit Bist, Laxmi Gautam

Infertility poses a multidimensional burden, especially for women in low- and middle-income countries, where it is often associated with social stigma, emotional distress, and limited support. This study aimed to assess the mental health status and its associated factors among women with fertility issues visiting fertility center in the Kathmandu Valley. A cross-sectional study was conducted from October 2023 to April 2024, and participant data collected from November 2023 to February 2024, among 143 women of repro …

27.08.2026journal-article

Journal of Central Banking Theory and Practice

Central Banks, Expectations and Collective Psychology - Limits and Possibilities of Behavioral Monetary Policy

Faruk Hadžić, Kemal Kozarić

Abstract This paper presents a critical review of the concept of animal spirits and its importance in shaping contemporary monetary policy. Starting from Keynes’s theoretical assumptions and contributions in the field of behavioral macroeconomics, the paper analyzes the ways in which psychological factors such as trust, optimism, fear and panic affect economic cycles, decision-making processes and the application of monetary policy measures. The methodological framework of the paper is based on a comprehensive anal …

27.08.2026journal-article

Finance and Credit

Tools of environmentally responsible budget policy in Russia: Classification, effectiveness, and application challenges

Mikhail E. KOSOV

Subject. A set of instruments of environmentally responsible budget policy (incentive, prohibitive and restrictive, budget‑expenditure, and institutional‑accounting ones) used in the Russian Federation and abroad, as well as the methodological foundations for their integration into the budget process. Objectives. To analyze the effectiveness of the existing green budgeting toolkit in Russia, to identify problems in its application, and to substantiate the need to develop a unified methodological framework for the s …

27.08.2026journal-article

Frontiers in Digital Health

From free association to free parameters: machine-learning empowers artificial intelligence models to rate the affective-relational aspects of narratives like an expert psychologist

Caleb J. Siefert, Barry Dauphin, Jenelle Slavin-Mulford, Sai Dileep Kumar Mukkamala, Venkat Akhila Reddy Tatipally, Areen Alsaid, Abdallah Chehade

Background Narrative assessment offers unique insight into psychological functioning but is resource-intensive, requiring extensive expert training and time. Recent work suggests Artificial Intelligence (AI), including moderately sized, adaptable large language models (LLMs), can master narrative assessment's complex, multi-step scoring rules. This study examined whether fine-tuning could enable AI raters to accurately assess narratives. Method We fine-tuned five diverse LLMs (3–7 billion parameters) on two dataset …

27.08.2026journal-article

Neuro-Oncology

150 The Value of Early Biological Information in Glioblastoma Drug Development: A Health Economic Evaluation of Window-of-Opportunity Trials

Melyda Melyda, Sue Jowett, Peter Auguste, Victoria Wykes, Collin Watts, Gary Middleton, Vinton Cheng

Abstract Introduction Window-of-opportunity (WoO) trials are increasingly proposed in glioblastoma drug development to test early biological activity (tumour penetration and target engagement), before progression to large, costly late-phase trials. While WoO designs may improve early decision-making, they introduce additional operational complexity and upfront costs. Their economic value remains uncertain. Methods An early decision-analytic model was developed to assess the cost-effectiveness of incorporating a WoO …

27.08.2026journal-article

Frontiers in Public Health

What limits a bystander’s action to perform cardiopulmonary resuscitation in China? Insights from a cross-sectional study conducted in Shaanxi Province

Dongdong Li, Kun Wang, Qiang Fu, Yan Li, Wangang Guo, Xiaolan Guo, Xin Zhang, Yuchan Hu, Liping Liao, Zhuoni Ma, Xin Chen, Miaomiao Cheng

Background Rate of bystander-initiated cardiopulmonary resuscitation (CPR) remains critically low in China. Identifying the underlying reasons may help reduce mortality from out-of-hospital cardiac arrest (OHCA). Methods A cross-sectional study was conducted among 572 participants in Shaanxi, China. A researcher-developed questionnaire was used to assess four domains: ability to recognize the need for CPR, willingness to perform CPR, internal concerns about initiating CPR, and actual CPR competence. Subgroup analys …

27.08.2026journal-article

Frontiers in Public Health

Population-level association of layperson cardiopulmonary resuscitation training with survival after out-of-hospital cardiac arrest: a systematic review and meta-analysis

Pan Pan, Zhou YaXiong, Jiang YaoWen, Xia YiQin, Chen Yao

Background Out-of-hospital cardiac arrest (OHCA) is a significant worldwide cause of death and is highly dependent upon bystander intervention. Layperson cardiopulmonary resuscitation (CPR) training has been widely promoted, but its population-level association with survival after out-of-hospital cardiac arrest remains incompletely characterized. Methods This systematic review and meta-analysis was conducted according to PRISMA guidelines and registered in PROSPERO. PubMed, Embase, Web of science and Cochrane Libra …

27.08.2026journal-article

European Health Psychologist

The opportunities, benefits, and challenges of applying health psychology in non-academic settings: summary of a roundtable discussion

Alice Le Bonniec, Lisa Hynes, Koula Asimakopoulou, Ana-Maria Schweitzer, Alexandra Dima

This article summarizes a roundtable discussion about the application of health psychology in non-academic settings that was presented at the EHPS conference 2024. Five contributors shared their experiences applying health psychology in non-academic settings. Contributors’ non-academic roles reflect a variety of applications for health psychology: cancer screening; cardiovascular disease prevention, medication adherence, pharmacy, and management of chronic conditions. They discussed the benefits of their roles such …

27.08.2026journal-article

Beijing International Review of Education

Teachers’ Dual Work Pressure, Emotional Labor, and Job Burnout in China Under the “Double Reduction” Policy

Penghui Hu, Ruilin Gao, Shasha Du

China's implementation of the “Double Reduction” (DR, Shuangjian ) policy has raised occupational demands for educators, intensified societal expectations and parental oversight, and thus exacerbated teachers’ family and interpersonal pressure. Based on survey data from 300 primary and secondary school teachers, this study explores the mechanism through which teachers’ dual work pressure is linked to job burnout via emotional labor. The results show that work pressure does not necessarily lead to job burnout, and d …

27.08.2026journal-article

BMC Women's Health

Long-term risk of second primary malignancies and symptomatic heart failure after pegylated liposomal doxorubicin versus conventional anthracycline-based chemotherapy in early-stage breast cancer survivors: a single-center experience

Yu-Ting Lee, Hsin-Yi Yang, Chi-Wen Tu, Yu-Chen Hsu, Min-Chieh Shieh, Cheng-Yen Lee, Chih-Chia Chang, Yuk-Wah Tsang, Yu-Wen Wang, Wei-Yu Wang, Chin-Ho Kuo, Ming-Yang Lee, Yin-Che Lu, Po-Yen Hsu, Michael W. Y. Chan

Abstract Background Anthracycline-based chemotherapy is a crucial treatment for early-stage breast cancer but be associated with second primary malignancy (SPM) and heart failure (HF). Pegylated liposomal doxorubicin (PLD) has been used as an alternative to conventional non-pegylated anthracyclines; however, long-term data regarding SPM and symptomatic HF after PLD-based treatment remain limited. This study evaluated the long-term risks of SPM and symptomatic HF and compared survival outcomes between PLD-based and …

27.08.2026journal-article

The Milbank Quarterly

Stigma as a Social Determinant of Health: A Policy Classification Framework and Call to Action

LISA CARTER‐BAWA

Policy Points Stigma functions as a social determinant of health (SDOH), producing population health inequities through resource deprivation, social exclusion, constrained health care, physiological stress, and diminished agency—yet it lacks formal SDOH classification. Because stigma operates as a fundamental cause of health inequalities, policy responses must extend beyond health care systems to encompass housing, employment, education, and social participation. Discrimination is already classified as an SDOH; for …

27.08.2026journal-article

American Journal of Health-System Pharmacy

Improving patient safety with triple-scan technology for insulin pen administration

Courtney K Wulffson, Melissa M Babin, Merissa T Andersen Pinotti

Abstract Purpose High-alert medications such as insulin pose serious risks to patients when used in error. In response to vulnerabilities identified in existing insulin administration workflows, we implemented a comprehensive approach to mitigate the risk of errors in the hospital setting. Summary A new electronic health record capability, referred to as the “triple-scan system,” was introduced to enhance insulin pen administration safety. This system requires nurses to scan the patient’s wristband barcode, the ins …

27.08.2026journal-article

IIARD International Journal of Banking and Finance Research

Effect of Public Expenditure on Human Capital Development in Nigeria (2008 – 2023)

Fabian Ajijias Okwajie

The study was an examination of the effect of public expenditure on human capital development in Nigeria from 2008 to 2023. The specific objectives were to evaluate the trends and patterns of public expenditure in Nigeria from 2008 to 2023, focusing on allocations to education, health, social protection, and technology infrastructure, evaluate the Impact of Public expenditure on Education on Human capital development, five research questions and four hypotheses guided the study. The study adopted the ex-post facto …