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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Nature Communications

An FGF21-IGFBP1 tumor-liver relay drives musculoskeletal defects in colorectal cancer cachexia

Joshua R. Huot, Urja R. Kamdar, Caleb J. Gammon, Patrick D. Livingston, Fabrizio Pin, Nicholas A. Jamnick, Natalia M. Weinzierl, Chandler S. Callaway, Paul A. Roberson, Alyson L. Essex, Jing Xu, Luis Felipe Cardona Polo, Michael W. Devereaux, Aimee L. Anderson, Colin T. Shearn, Ronald J. Sokol, Schuyler Lee, Bifeng Gao, Meher P. Boorgula, Andrew Goodspeed, Leah J. Novinger, Douglas J. Adams, Andrea Bonetto

Abstract Colorectal cancer (CRC) is frequently accompanied by cachexia, a wasting syndrome characterized by progressive loss of muscle and bone that worsens physical function and survival. Although liver dysfunction is increasingly recognized in cachexia, whether tumor-induced liver signaling contributes directly to musculoskeletal decline remains unclear. Here we show that CRC establishes a tumor-liver endocrine relay in which tumor-derived fibroblast growth factor 21 (FGF21) stimulates hepatic production of the h …

27.08.2026journal-article

Frontiers in Oncology

E3 ubiquitin ligases orchestrate chemo-resistance in gastrointestinal malignancies: from DNA damage response to therapeutic targeting

Teng Ma, Yongzhu Zhou, Xiaojun Li, Junhong Guan

Therapy resistance in gastrointestinal tumors remains a critical challenge in clinical oncology, severely compromising therapeutic efficacy and long-term patient survival. E3 ubiquitin ligases, as core enzymes involved in the protein ubiquitination process, have been demonstrated to play indispensable roles in regulating key biological processes in tumor cells, including DNA damage repair, cell cycle progression, apoptosis, cancer stem cell maintenance, and immune evasion. Additionally, E3 ligases are key regulator …

27.08.2026journal-article

Physics in Medicine & Biology

Patient-Specific Stopping Power Calibration of Treatment Planning X-Ray CT Using Integrated Depth-Dose Profiles Acquired by Proton Transmission Imaging - A Feasibility Study

Ines Butz, Katia Parodi, Chiara Gianoli

Abstract Objective: Range uncertainties in proton therapy largely arise from the semi-empirical conversion of X-ray computed tomography (CT) Hounsfield Units to stopping power relative to water (RSP), requiring generous safety margins or robust optimization. Pencil beam-wise integrated depth-dose profiles (IDDs), obtained via proton transmission imaging using a particle integrating detector, can be combined with the treatment planning CT to obtain patient-specific conversion curves. Existing calibration approaches …

26.08.2026journal-article

Frontiers in Immunology

The paracrine effects of tumor cells on endothelial cells and macrophages in brain metastases with different primary sites

Tamer A. Kaya, Klaus-Peter Stein, Belal Neyazi, Ali Rashidi, Ulf D. Kahlert, Christian Mawrin, I. Erol Sandalcioglu, Claudia A. Dumitru

Background Brain metastases (BrMs) represent the most common intracranial tumors, which occur at a significantly higher incidence than primary brain neoplasms. Although some studies addressed the modulation of endothelial cells (ECs) and macrophages in lung and breast BrMs, it is still unclear how these cells are modulated in other BrM types. Methods Tumor cells (TCs) were isolated from human melanoma, lung and gastrointestinal (GI) BrM tissues, using individual patient isolates (n=2 per tissue origin) as the prima …

26.08.2026journal-article

Frontiers in Oncology

PLK1/FOXM1-associated tumor-cell state and macrophage-related immune features in endometrial cancer

Longwei Li, Yunyun Xiao, Yaping Wang, Guangyao Song, Ming Liu, Xueling Qu, Lu Han

Background Polo-like kinase 1 (PLK1) and forkhead box M1 (FOXM1) have been widely studied in various cancers; however, their expression characteristics in endometrial cancer (EC) and their potential association with tumor microenvironment remodeling remain insufficiently characterized. Methods This study integrated The Cancer Genome Atlas uterine corpus endometrial carcinoma cohort, Gene Expression Omnibus, pan-cancer transcriptomic data, Human Protein Atlas/Clinical Proteomic Tumor Analysis Consortium, and local i …

26.08.2026journal-article

Frontiers in Oncology

Effects of embedded micro-mindfulness on psychological symptoms in patients with advanced cancer receiving palliative care: a prospective controlled study

Qin Zhang, Qianer Li, Aiping Deng, Dan Yang, Dan Jia

Objective To evaluate changes in psychological distress, anxiety and depressive symptoms, sleep problems, and pain intensity associated with participation in an embedded micro-mindfulness program among patients with advanced cancer receiving palliative care, and to explore factors associated with psychological symptom response. Methods This single-center, prospective, non-randomized observational study included 243 patients with advanced cancer receiving palliative care at West China Hospital. Patients who particip …

26.08.2026journal-article

Health Science Reports

Study Protocol for Assessment of the Feasibility of an Intraoperative Localization Technique Using Augmented Reality in Breast‐Conserving Surgery for Non‐Palpable Cancer Lesions: A Feasibility Study

Alexia Giro, Judith Passildas, Emilie Thivat, Ioana Molnar, Céleste Pinard, Wissam Marraoui, Adrien Bartoli, Rasoul Sharifian, Nicolas Bourdel, Catherine Abrial, Christophe Pomel, Xavier Durando, Sabrina Madad‐Zadeh

ABSTRACT Background and Aims Localizing non‐palpable cancerous lesions of breast‐conserving surgery is a major challenge. Augmented reality (AR) and 3D imaging are emerging tools for surgical guidance. This study evaluates the feasibility of a noninvasive intraoperative localization technique using AR. Methods This prospective, interventional, single‐center proof‐of‐concept study investigates AR‐assisted localization of non‐palpable breast lesions. Secondary objectives include surgical time assessment, breast phant …

26.08.2026journal-article

Arthritis Care & Research

Associations of Frailty with the Risk of Incident Cancer and Cancer‐related Mortality in Veterans with Rheumatoid Arthritis

Bhavik Bansal, Aaron Baraff, Katherine Wysham, James S. Andrews, Bryant R. England, Ted R. Mikuls, Joshua Baker, Kaleb Michaud, Alexa Meara, Una Makris, Carolyn Presley, Ariela Orkaby, Namrata Singh

Objective To investigate the association between frailty and cancer incidence and mortality in patients with rheumatoid arthritis (RA). The study aimed to identify how frailty influences cancer risk, and cancer‐specific outcomes. Methods This retrospective cohort study analyzed data from the Veterans Affairs Rheumatoid Arthritis (VARA) registry (2002–2023). Frailty status was categorized at baseline using the Veterans Affairs Frailty Index (VAFI): robust (VAFI <0.10), pre‐frail (VAFI 0.11–0.20), and frail (VAFI >0. …

26.08.2026journal-article

Canadian Journal of Microbiology

Peptidylarginine Deiminase Inhibitor Treatment is Associated with Increased Phage Susceptibility in Erwinia amylovora

Nassereldin Ibrahim, Antonet M. Svircev, Hany Anany, Joel Weadge

Understanding the phage resistance mechanisms in Erwinia amylovora is crucial for improving phage therapy applications targeting this plant pathogen, which is responsible for fire blight disease in apple and pear orchards. This study investigated E. amylovora phage resistance in the presence of peptidylarginine deiminase (PAD) inhibitors, which have been found in other studies to prevent the conversion of arginine to citrulline as a post-translational modification that may initiate outer membrane vesicle (OMV) form …

26.08.2026journal-article

Cancer Immunology Research

EphA4 Mediates Pro- and Antitumoral Effects Through Upstream Negative Regulation of AKT in Head and Neck Squamous Cell Carcinoma

Sophia Corbo, Khalid N.M. Abdelazeem, Diemmy Nguyen, Shilpa Bhatia, Benjamin Van Court, Nicholas A. Olimpo, Jacob Gadwa, Chloe A. Hodgson, Jessica I. Beynor, Von G. Samedi, Enrique Sanz-Garcia, Lillian L. Siu, Anthony J. Saviola, Lynn E. Heasley, Elena B. Pasquale, Michael W. Knitz, Sana D. Karam

Abstract Head and Neck Head and Neck Squamous Cell Carcinoma (HNSCC) is driven by an immunosuppressive tumor microenvironment (TME). We examined the immune-modulatory role of EphA4 in HNSCC using spatial analysis, multi-compartment RNA-sequencing from Oral Cavity Squamous Cell Carcinoma (OCSCC), and three genetically engineered mouse models. Within the HNSCC TME, EphA4 is primarily expressed in Tregs, macrophages, CD8+ T cells, and HNSCC cancer cells. EphA4 in Tregs promotes tumor growth, whereas EphA4 in myeloid c …

26.08.2026journal-article

Radiation Sciences in Oncology

Outcomes of stereotactic body radiotherapy for large lung lesions: Is tumor size still a limiting factor?

Pantea Bayatfard, İpek Sucak, Serap Akyürek

Objective: Evidence regarding stereotactic body radiotherapy (SBRT) for large lung lesions remains limited because most prospective trials excluded tumors ≥5 cm owing to concerns regarding treatment-related adverse events (AEs). We evaluated the efficacy and safety of SBRT in patients with large (≥4 cm) primary lung lesions. Materials and Methods: We retrospectively analyzed 29 consecutive patients with lung lesions ≥4 cm who underwent SBRT between 2020 and 2024. Clinical outcomes included radiologic response per R …

26.08.2026journal-article

Radiation Sciences in Oncology

Associations of psoas muscle index and inflammatory markers with FDG PET/CT-derived metabolic response after total neoadjuvant therapy in locally advanced rectal cancer

Gizem Kavak, Mehmetcan Atak, Osman Sütçüoğlu, Semra Demirtaş Şenlik, Özlem Özmen, Ömür Berna Çakmak Öksüzoğlu, Yıldız Güney

Objective: Total neoadjuvant therapy (TNT) is increasingly used for locally advanced rectal cancer, but factors associated with metabolic tumor response remain unclear. This study aimed to explore correlations between fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT)-derived metabolic tumor response and patient-related factors, including body composition, systemic inflammatory markers, and imaging-based biomarkers, in patients receiving TNT. Materials and Methods: This retrospective s …

26.08.2026journal-article

BMC Cancer

Stage-dependent upregulation of tumor-derived MDK is associated with CAF state remodeling and an ECM-rich immunosuppressive microenvironment in colorectal cancer

Xia Liu, Siyuan Ma, Shuai Wu, Aiyuan Wang, Dan Zhu, Wentian Liu, Weilong Zhong

Abstract Background Cancer-associated fibroblasts (CAFs) exhibit substantial heterogeneity in colorectal cancer (CRC), yet the upstream tumor-derived signals associated with their state remodeling during disease progression remain incompletely defined. Through integrative analysis of multi-cohort single-cell transcriptomics, proteomics, and bulk RNA sequencing data, we identified tumor-derived midkine (MDK) as a stage-associated candidate signal linked to CAF remodeling in CRC. Methods MDK cell-type specificity and …

26.08.2026journal-article

Cerrahpaşa Medical Journal

A Novel Homozygous CFH Variant Associated with Atypical Hemolytic Uremic Syndrome Triggered by Colorectal Cancer: A Case Report

Mert Berke Gür, Şeyda Gül Özcan, Mevlut Tamer Dinçer, Ahmet Murt, İclal Gürses, Sinan Trabulus, Nurhan Seyahi

Complement-mediated thrombotic microangiopathy (cmTMA), historically referred to as atypical hemolytic uremic syndrome, is driven by dysregulated alternative complement activation and is often unmasked by secondary triggers. A 40-year-old man with pre-existing hypertension (peak blood pressure: 145/94 mmHg) who presented with microangiopathic hemolytic anemia, severe thrombocytopenia, and acute kidney injury requiring hemodialysis is reported. Therapeutic plasma exchange was initiated while thrombotic thrombocytope …

26.08.2026journal-article

Nephrology Dialysis Transplantation

GLP-1 receptor agonists are associated with lower kidney cancer risk after metabolic bariatric surgery

Jesús Gibran Hernández-Pérez, Omer Abdelgadir, Mohanad Albayyaa, Deepali K Ernest, Jing Chen, Stacia M DeSantis, Arthur S Hong, Lindsay G Cowell, Jaime P Almandoz, Sarah E Messiah, David S Lopez

Abstract Background Kidney cancer (KC) is an obesity-related malignancy with rising incidence. Although metabolic and bariatric surgery (MBS) reduces the risk of some obesity-related cancers, the use of glucagon-like peptide-1 receptor agonists (GLP-1 RA) has increased after MBS; however, their association with KC risk remains unclear. We aimed to evaluate whether initiation of GLP-1 RA, compared with other glucose-lowering agents, is associated with KC among adults with prior MBS and type 2 diabetes (T2D), and ove …

26.08.2026journal-article

Catalysts

Treatment of Fracturing Flowback Fluid Using a Plasma-Fenton Coupled Process: Performance Evaluation and Parameter Optimization

Meiqi Shi, Fuping Feng, Jianwei Zhang, Xueqin Wang, Hong Jiang, Xu Han

Fracturing flowback fluid poses significant pollution risks and potential threats to the surrounding ecological environment, especially soil and groundwater systems. This study innovatively combined the dielectric barrier discharge (DBD) low-temperature plasma technology with the Fenton oxidation process to construct a synergistic degradation system. Systematic investigation of key operational parameters, including discharge voltage, H2O2 and Fe2+ dosages, and initial pH, was conducted to evaluate their effects on …

26.08.2026journal-article

Annals of Surgical Oncology

Fertility Preservation Pathways in Young Women With Breast Cancer: A Single-Center Analysis in a Publicly Funded System

Elisheva Strauss, Jordana Hyman, Shani Paluch-Shimon, Shani Breuer, Ido Ben-Ami, Naama Srebnik, Hen Y Sela, Avi Tsafrir

Abstract Background Fertility concerns are central to the care of young women with breast cancer. Cancer treatments and chemotherapeutic regimens may adversely affect reproductive potential. Despite extensive attention to fertility preservation (FP), reported uptake remains low. It remains unclear how patients progress through the fertility preservation process within publicly funded health care systems that reduce financial and access barriers. Methods Key time points in the patient care sequence were assessed, be …

26.08.2026journal-article

Journal of General Internal Medicine

Clinicians’ Perception and Management of Cancer Patients’ Decision Making Burden

Fiorella L. Huijgens, Inge Henselmans, Mette J. Huisinga, Gwen M. P. Diepenhorst, Hanneke W. M. van Laarhoven, Anke J. M. Oerlemans, Marij A. Hillen

Abstract Background Clinicians in cancer care are increasingly expected to involve patients in treatment decision making. Some patients may feel burdened by such involvement. It is unclear how clinicians recognize and respond to patient burden in shared decision making (SDM). Objective We aimed to gain more insight into experiences of oncology clinicians regarding patients’ burden of involvement in decision making. Design We used semi-structured in-depth qualitative interviews. Participants and Approach Clinicians …

26.08.2026journal-article

Journal of modern medicine

RESULTS OF SURGICAL TREATMENT FOR HYPERTROPHIC PSEUDOARTHROSIS OF THE HUMERUS DIAPHYSIS

A.M. Dursunov, O.Sh. Ruziqulov

<p>Introduction. Diaphyseal fractures of the humerus, complicated by incorrect selection of osteosynthesis technique, insufficient consideration of clinical risk factors, violation of orthopedic regimen by the patient, etc., lead to significant changes not only in the segment but also in the function of the upper limb. In this regard, an important stage is not only the clinical and radiological assessment of the condition of the injured limb and the type of false joint, but also the assessment of the significance o …

26.08.2026journal-article

Frontiers in Cellular and Infection Microbiology

NLRC4 and NLRP3 in tissues as potential biomarkers for the diagnosis of non-small cell lung cancer in pulmonary tuberculosis

Zetian Zhang, Zhikai Zhao, Shuanshuan Xie, Boyu Guo, Chenlei Cai, Chunyan Wu, Xiaohui Hao, Jian Ni, Haiyan Cui, Mengting Xiong

Background Distinguishing non-small lung cancer (NSCLC) with tuberculosis from pulmonary tuberculosis (PTB) is still a major clinical problem. Misdiagnosis or missed diagnosis can lead to missed opportunities for optimal treatment, making highly sensitive diagnostic criteria crucial. Methods Database analysis and histological analysis were used at the same time. A total of 55 patients were included in the histological analysis, including 20 patients with both NSCLC and PTB (NSCLC-PTB group), 20 patients with NSCLC …

26.08.2026journal-article

Frontiers in Oncology

Deep learning-radiomics-SUVmax integration from 18F-FDG PET/CT predicts synchronous distant metastasis in nasopharyngeal carcinoma

Yun Zhang, Ying Cao, Shanshan Xu, Yan Tang, Jian He, Jing Chen, Ziwei Nie, Yuxiao Hu

Objectives This study aimed to develop and evaluate deep learning (DL) models of primary tumor (T) and cervical metastatic lymph nodes (CMLNs) using fluorine-18 fluorodeoxyglucose positron emission computed tomography ( 18 F-FDG positron emission tomography/computed tomography (PET/CT)) imaging for predicting synchronous distant metastasis (SDM) in nasopharyngeal carcinoma (NPC) patients, integrating radiomic features, primary tumor maximum standardized uptake value (SUVmax-T) and clinical features. Methods A two-c …

26.08.2026journal-article

Frontiers in Public Health

Efficacy of traditional Chinese medicine nursing for lung cancer: a systematic review and meta-analysis using the Donabedian model to investigate heterogeneity

Ting Duan, Yuxin Liu

Background Lung cancer patients frequently experience a reduced quality of life and psychological distress during treatment. Traditional Chinese Medicine (TCM) nursing shows promise, but substantial heterogeneity in the evidence base limits clinical interpretation. Methods A comprehensive literature search identified 15 randomized controlled trials (RCTs) involving 1,135 participants. A meta-analysis was conducted using RevMan 5.4 and Stata 17. Following the Donabedian framework, data were categorized into structur …

26.08.2026journal-article

Frontiers in Medicine

Clinical efficacy, safety evaluation, and mechanism of acetylcysteine in improving first-line anti-tuberculosis treatment of newly diagnosed pulmonary TB: an open-label, randomized, single-center trial

Huan Zhang, Ming Liu, Lu Shi, Xianlei Wang, Jiong Xie, Qingyan Ma

Objective To investigate the clinical efficacy, safety and mechanism of N-acetylcysteine combined with conventional antituberculosis drugs in the treatment of newly diagnosed pulmonary tuberculosis. Methods A total of 90 newly diagnosed pulmonary tuberculosis patients were randomly assigned to a Control group ( n = 30), Aerosol NAC group ( n = 30), or Oral NAC group ( n = 30). The Control group received standard HRZE therapy, whereas the Aerosol NAC and Oral NAC groups received additional nebulized N-acetylcysteine …

26.08.2026journal-article

Biological Products. Prevention, Diagnosis, Treatment

Antiviral activity of interferon α-2b against SARS-CoV-2 in Calu-3 human lung adenocarcinoma cell culture

D. M. Khokhlova, A. V. Gracheva, E. R. Korchevaya, A. S. Maslennikova, I. A. Leneva, O. A. Svitich, V. V. Zverev, E. B. Faizuloev

INTRODUCTION. Despite the reclassification of the SARS-CoV-2 coronavirus as an etiological agent of seasonal respiratory viral infections, the problem of developing drugs against COVID-19 remains relevant. The development of antiviral drugs requires an adequate cellular model of infection to search for and test inhibitors of viral reproduction. AIM. To study the feasibility of using a Calu-3 human lung adenocarcinoma cell culture-based test system to evaluate the antiviral activity of recombinant human interferon α …