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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

International Archives of Medical Research

Treatment of Multiple Cairo RT2 Gingival Recessions with the Tunnel Technique and a Subepithelial Connective Tissue Graft: A Case Report

Bülent Ulaştan

Multiple Cairo RT2 gingival recessions present esthetic and functional challenges in periodontal therapy. This case report describes the treatment of multiple Cairo RT2 gingival recessions using the tunnel technique combined with a subepithelial connective tissue graft in a 42-year-old woman. Clinical evaluation at 6 and 12 months demonstrated complete root coverage at most treated sites, increased keratinized tissue width, shallow probing depths, and complete resolution of dentin hypersensitivity. The patient was …

26.08.2026journal-article

Health Science Reports

The Therapeutic Effects of Crocus sativus L . and Its Constituents on the Improving Treatment of Azoospermia: A Narrative Review

Faraz Khakshour, Melika Hadad Tehran, Jamal Jalili Shahri, Farid Zeynali, Fahimeh Lavi Arab

ABSTRACT Background and Aims Azoospermia, defined as the complete absence of sperm in the ejaculate, is a major cause of male infertility and is classified into obstructive and non‐obstructive forms. While obstructive azoospermia is primarily mechanical in origin, non‐obstructive azoospermia (NOA) is characterized by impaired spermatogenesis and is frequently associated with oxidative stress, inflammation, and hormonal dysregulation. Crocus sativus L . and its bioactive constituents exhibit antioxidant and anti‐inf …

26.08.2026journal-article

Water

Evaluation of a Partially Hydrolyzed Poly(vinyl acetate) Copolymer for Surface Water Treatment: Application to Water from the Joumine Dam (Tunisia)

Marwa Amri, Khaoula Fouzai, Marwa Gatrouni, Asma Bouatrous, Abbes Chaabane, Henrique Pinho, Nedra Asses, Dina Mateus

Aquatic ecosystems are increasingly affected by anthropogenic pollution, highlighting the need for efficient and advanced water treatment technologies. Poly(vinyl alcohol-co-vinyl acetate) copolymer (PVA-co-PVAc), a partially hydrolyzed copolymer derived from poly(vinyl acetate), has received limited attention for surface water remediation. To address this gap, PVA-co-PVAc was prepared and evaluated as an alternative material for surface water treatment. The polymer identity was inferred from the synthesis route an …

26.08.2026journal-article

FASEB BioAdvances

Supraphysiological 25‐Hydroxyvitamin D 3 and Calcipotriol Induce Reactive Oxygen Species, Mitochondrial Dysfunction and Apoptosis in HeLa Cervical Cancer Cells

Hoi Ching Cherry Chan, Sachin Bhoora, Esther Zhou, Sumari Marais, Tahir S. Pillay, Rivak Punchoo

ABSTRACT Cervical cancer remains a major global health challenge, necessitating continued advances in therapeutic strategies. Emerging evidence suggests that vitamin D derivatives may exert anti‐cancer effects, including induction of apoptosis, potentially through redox‐dependent mechanisms. This study investigated whether vitamin D exposure is associated with reactive oxygen species (ROS) accumulation, mitochondrial dysfunction, and apoptosis in cervical cancer cells. HeLa cells were exposed to physiological, inte …

26.08.2026journal-article

International Surgery Journal

Oncological treatment and upper lip reconstruction in basal cell carcinoma: case report and review of reconstructive options

Carla M. Cruz Rocha, Jose D. Tellez Gonzalez, Danna Gonzalez Delgado, Liliana A. Cuevas Mejia, Besser I. Irias Vasquez, Daniela I. Sanchez Lozano, Carlos A. Bautista Lopez, Maria del C. Torres Gonzalez

Basal cell carcinoma (BCC) is the most common cutaneous malignancy and frequently affects sun-exposed facial regions. Lesions of the upper lip are considered high risk due to their tendency for local invasion, recurrence, and involvement of critical functional and aesthetic subunits. Optimal management requires complete oncologic excision followed by anatomically precise reconstruction. We report the case of a 66-year-old woman with a recurrent nodular BCC of the upper lip after prior incomplete excision. Margin-co …

26.08.2026journal-article

Behavioral Sciences

Behavioral and Psychosocial Predictors of Treatment Response in Emergency Psychiatric Admissions for Substance Use Disorders in a Socioeconomically Vulnerable Region of Southeastern Romania: A Five-Year Retrospective Study

Ionela-Violeta Ragea, Simona-Dana Mitincu-Caramfil, Rusu-Negraia Magdalena, Cătălin Pleșea-Condratovici, Valeriu Ardeleanu, Ramona-Oana Roșca, Laurențiu Drăguș, Lavinia-Alexandra Moroianu

Substance use disorders (SUDs) represent a major psychiatric and public health burden. Although integrated biopsychosocial approaches combining pharmacotherapy with psychosocial and behavioral interventions are recommended by international guidelines, real-world evidence on their effectiveness in acute emergency settings remains scarce, particularly in Eastern European healthcare contexts. This single-center, retrospective, observational study examined behavioral and psychosocial predictors of clinical response and …

26.08.2026journal-article

BMC Oral Health

Why patients delay or decline treatment for gingival recession: a qualitative study

Omid Fakheran, Erfan Davari Dolatabadi, Sajede Sheydaei, Majid Shahmoradi

Abstract Background Gingival recession is a common mucogingival condition associated with esthetic concerns, dentin hypersensitivity, and root-surface complications that may impair oral health-related quality of life. Nevertheless, some patients delay or decline treatment despite being aware of the condition. This study explored patient-perceived barriers to seeking treatment for gingival recession. Methods Semi-structured, face-to-face interviews were conducted with 15 participants who were aware of their gingival …

26.08.2026journal-article

Journal of Surgical Oncology

Unplanned Healthcare Utilization Following the Surgical Management of Musculoskeletal Tumors: A Retrospective Cohort Study

Devika A. Shenoy, William C. Cruz, Kevin A. Wu, Aaron D. Therien, Malcolm DeBaun, Christian A. Pean, Brian Brigman, Julia D. Visgauss, William C. Eward

ABSTRACT Background and Objectives Orthopaedic oncology patients are susceptible to unplanned return to the emergency department (RTED) and readmission postoperatively. This study aims to explore factors contributing to unplanned healthcare utilization in patients undergoing surgery for musculoskeletal tumors. Methods We conducted a single‐institution retrospective cohort study of orthopaedic oncology patients from 2017 to 2023. Demographic variables (race, ethnicity, language, insurance, age) and procedure details …

26.08.2026journal-article

Revista Metropolitana de Ciencias Aplicadas

Hypertension: a comprehensive review of risk factors, pathophysiology, complications, and treatment strategies

Iako Shiukashvili

Hypertension is one of the most prevalent chronic noncommunicable diseases and represents a major public health challenge because of its high prevalence, silent progression, and close association with cardiovascular, cerebrovascular, and renal diseases. The aim of this narrative review was to synthesize the available scientific evidence on the risk factors, pathophysiological mechanisms, major complications, and therapeutic strategies for the comprehensive management of hypertension. To achieve this, a qualitative …

26.08.2026journal-article

Health Science Reports

Detection of Pancreatic Cancer via Specific Metabolite Markers: A Metabolomics Approach

Mohammad Javad Roustaye Gourabi, Mehrangiz Ghafari, Anita Nikoo, Yalda Yarahmadi Saki, Bita Khanbabaei, Masoumeh Khanizadeh, Masoud Kargar, Ali Hashemi, Javad Yasbolaghi Sharahi

ABSTRACT Background and Aims Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies worldwide because most patients are diagnosed at advanced stages when curative treatment is no longer feasible. Metabolomics has emerged as a promising strategy for identifying biochemical alterations associated with early tumor development and may improve the early detection of PDAC. This review critically evaluates the role of metabolomics in PDAC diagnosis, focusing on metabolite biomarkers, nuclear m …

26.08.2026journal-article

Cardio-Oncology

Baseline proteomic biomarkers for predicting chemotherapy-induced cardiotoxicity in breast cancer patients

Li-Rong Yu, Zhijun Cao, Dong Wang, Jaclyn R. Daniels, Valentina K. Todorova, Issam Makhoul, V. Suzanne Klimberg, Jeanne Wei, Jane P. F. Bai, Julia Tait Lathrop, Majda Haznadar Uskievich, Jinong Jenn Li, William Mattes, Richard D. Beger

Abstract Background Currently, there are no reliable biomarkers to identify patients at high risk of treatment-related cardiotoxicity before initiation of chemotherapy. The aim of this study was to identify biomarkers for predicting asymptomatic decrease in left ventricular ejection fraction (LVEF) after doxorubicin (DOX)-based chemotherapy. Methods A total of 83 breast cancer patients were treated with DOX-based chemotherapy. LVEF was measured before initiation and after completion of therapy. Thirty-nine patients …

26.08.2026journal-article

Cancer Medicine

Diagnostic BMI and Induction Therapy Weight Change Associated With Hepatotoxicity in Pediatric Patients With Acute Lymphoblastic Leukemia

Emily J. Mason, John P. Woodhouse, Jeremy M. Schraw, Joanna S. Yi, Karen R. Rabin, M. Monica Gramatges, Mark C. Zobeck, Baojiang Chen, Melissa B. Harrell, Olga A. Taylor, Michael E. Scheurer, Philip J. Lupo, Van Huynh, Steven D. Mittelman, Etan Orgel, Austin Brown

ABSTRACT Background Hepatotoxicity is a common treatment‐related complication in pediatric acute lymphoblastic leukemia (ALL). Excess adiposity at diagnosis has been identified as a risk factor, but the impact of weight change during therapy has not been examined. Methods We included patients aged 2–20 years newly diagnosed with ALL between 2005 and 2021. Hepatotoxicity was defined as: (1) transaminitis (ALT/AST > 10× the upper limit of normal), or (2) conjugated hyperbilirubinemia (cbili; > 3.0 mg/dL during induct …

26.08.2026journal-article

Applied Physiology, Nutrition, and Metabolism

The Acute Response of Cytotoxic T Cells Following Work-Matched Continuous Moderate Intensity and High Intensity Interval Exercise in Metastatic Cancer Patients Undergoing Chemotherapy : a Pilot Study

Hugo Parent-Roberge, Adeline Fontvieille, Laurence Poirier, Lee-Hwa Tai, Michel Pavic, Tamàs Fulop, Eléonor Riesco

Tumor-bearing animal studies have suggested that aerobic exercise may acutely enhance anti-tumor immunity, partly by mobilizing effector cytotoxic T-cells (CTLs) in the bloodstream during exercise. This acute immune response being strongly driven by intensity, high-intensity interval exercise (HIIE) might thus be a promising strategy to stimulate anti-cancer immunity in cancer patients. Yet, so far, the acute effects of moderate continuous (MOD) and HIIE on circulating T-cells remain unknown in patients receiving c …

26.08.2026journal-article

Neuro-Oncology Practice

Association of Early Postoperative MRI-Based RANO-Resect With Survival in WHO 2021-Defined IDH-Mutant High-Grade Gliomas

Guiliang Liu, Juan Liu, Qian Li, Qianzi Xue, Mulin Xie, Xunxun Wang, Yu Cai, Zhong Deng, Shuwen Yang, Xiaoyan Zhang, Rui He, Weiyu Liu, Xuzhe Zhao, Fanfan Chen

Abstract Background Direct evidence for postoperative residual-burden stratification remains limited in WHO 2021-defined isocitrate dehydrogenase (IDH)-mutant high-grade gliomas. We evaluated whether early postoperative MRI-based Response Assessment in Neuro-Oncology resect (RANO-resect) was associated with overall survival (OS) and progression-free survival (PFS). Methods This single-center retrospective cohort study screened consecutive patients undergoing first resection for newly diagnosed diffuse glioma betwee …

26.08.2026journal-article

JNCI Cancer Spectrum

Race, ethnicity, and prior colorectal screening test use in CONFIRM colonoscopy vs fecal immunochemical testing trial participants

Douglas J Robertson, Jason A Dominitz, Alexander Beed, Kathy Boardman, Barbara J Del Curto, Peter D Guarino, Grant D Huang, Thomas F Imperiale, Andrew LaCasse, Meaghan Larson, Samir Gupta, David Lieberman, Beata Planeta, Timothy J O’Leary, Aasma Shaukat, Shanaz Sultan, Tassos C Kyriakides, the CONFIRM Study Group, Ioannis Anastasiou, Fadi Antaki, Gyorgy Baffy, Divya Bhatt, Kerry Brandt Dunbar, Jill Elwing, Paul Feldman, Ronald S Fernando, Deborah A Fisher, Andrew J Gawron, Jeffrey A Gill, Stephan Goebel, Susan F Goldsmith, Katarina B Greer, Ildiko Halasz, Minh Q Ho, Nancy Ho, Samuel B Ho, Mazen Jamal, Charles J Kahi, Andrew M Kaz, Natalia Khalaf

Abstract Background Colorectal cancer (CRC) outcomes vary by both race and ethnicity, and screening test use may contribute to this variation. We examined the association of race, ethnicity, and associated factors with CRC screening test use in a setting where financial barriers to screening are mitigated. Methods Survey information was gathered from US Veteran participants (N = 50,125) when enrolled into a randomized trial comparing screening colonoscopy to annual fecal immunochemical testing (FIT) in the preventi …

26.08.2026journal-article

Frontiers in Oncology

Construction and internal validation of a risk prediction model for rapid bone loss during aromatase inhibitor therapy

Renda Jiang, Luning Wu, Liangying Zhao, Jiang Wang, Dalei Chen, Lingqiao Hu, Shiyu Wu, Chaoqun Chen, Guinv Hu

Purpose To establish and validate a risk prediction model for identifying hormone receptor-positive breast cancer patients at high risk of aromatase inhibitor-associated rapid bone loss. Methods This single-center retrospective study enrolled 247 patients receiving aromatase inhibitor (AI) therapy between 2016 and 2025. Rapid bone loss, defined as an annual bone mineral density (BMD) loss rate greater than 4% at either the lumbar spine or total hip, was the primary outcome. Predictor selection was conducted using t …

26.08.2026journal-article

Frontiers in Cell and Developmental Biology

RUNX1T1 drives stem-like small-cell neuroendocrine prostate cancer identity

Ziqin Wang, Hyeryeon Jung, Changhyeon Hong, Nancy Chen, Yunsol Jo, Issac Jung, Taeeun Kim, Gina Lee, Keaton Chien, Ming Chen, Jiaoti Huang, Jung Wook Park

Neuroendocrine prostate cancer (NEPC) or small-cell neuroendocrine prostate cancer (SCNPC) is increasingly recognized as a treatment-resistant disease arising among prostate adenocarcinoma (PRAD) patients. It has no effective therapy due to incomplete understanding of the mechanisms underlying treatment-induced cancer cell identity switching. Here, we identified RUNX1 Partner Transcriptional Co-Repressor 1 (RUNX1T1) as a frequently amplified gene in prostate cancer patients, associated with a poorer prognosis. RUNX …

26.08.2026journal-article

Current Oncology

Expert Consensus Develops Multidisciplinary Pathway for Cancer Pain Management in Italy: A Delphi Study

Francesco Cellini, Leonardo Consoletti, Massimo Di Maio, Diego Maria Michele Fornasari, Gianpaolo Fortini, Marta Gentili, Marco Krengli, Ernesto Maranzano, Silvia Natoli, on behalf of the Cancer Pain Management in Italy Working Group

Background: Cancer pain remains highly prevalent and undertreated despite established guidelines. In Italy, Law 38/2010 mandates systematic pain assessment, yet only 26% of clinicians routinely evaluate pain at each clinical visit, and fewer than one-quarter have received formal training in pain medicine or palliative care. A national multidisciplinary roundtable, convened in Rome in March 2025, formally identified four systemic gaps—insufficient education, fragmented care pathways, unclear professional roles, and …

26.08.2026journal-article

Health Science Reports

Does Preoperative Mixed‐Growth Urine Culture Increase the Risk of Urinary Tract Infection After Ureteroscopic Stone Treatment? A Retrospective Study

Khalid Elsayed Mahmoud, Ahmad R. Al‐Qudimat, Ahmed Khaled Alhusban, Raed M. Al‐Zoubi, Mai Elaarag, Abdulkader Alobiedly, Ibrahim A. khalil, Abdulla AlAnsari

ABSTRACT Background Ureteroscopy (URS) has emerged as a leading treatment option for urinary stones, with its usage growing from 30% to 70% over the last 20 years. Post‐URS complications, particularly infectious issues like UTIs, remain a concern, occurring in up to 25% of cases. This study aims to explore the relationship between preoperative mixed‐growth urine culture and postoperative outcomes of URS, addressing a critical gap in understanding the value and influence of these cultures. Methodology This retrospec …

26.08.2026journal-article

Cancers

Immune Checkpoint Inhibitors and Platelets from Treatment-Induced Thrombocytopenia to Complex Immune and Immune-Related Adverse Events

Árpád Illés, Miklós Udvardy, Zsófia Miltényi

Immune checkpoint inhibitor-induced immune thrombocytopenia (ICI-ITP) is a rare but severe adverse event that may lead to bleeding complications and may require therapeutic changes or interventions. The clinical condition and interventions are highly complex; there are certainly tumour-type and combination-therapy differences, as well as individual ICI-agent factors that modify the risk of thrombocytopenia. ICI-ITP shares some common features, even though its pathogenesis differs markedly from that of traditional I …

26.08.2026journal-article

N.N. Priorov Journal of Traumatology and Orthopedics

COMPARATIVE ANALYSIS OF TREATMENT RESULTS IN PATIENTS WITH FRACTURES OF THE TIBIAL CONDYLES.

Magomedrauf Hadiyevich Ganiev, Akshin B. Bagirov, Najmudin Omarkadiyevich Kallaev, Alevdin Rashidkhanovich Ataev, Parviz Nizam Suvarly

Intra-articular fractures of the tibial condyles are one of the most common and complex types of injuries. The relevance of the problem of treating patients with fractures of this localization is due not only to the high prevalence, but also to the difficulties of diagnosis, as well as the complexity of repositioning and fixation of fragments, which leads to frequent unsatisfactory outcomes. Good results can be achieved with complete restoration of the cogruence of the tibial plateau, stable fixation of fragments a …

26.08.2026journal-article

Frontiers in Psychiatry

A pilot randomized controlled study of a digital art therapy paradigm for children with ASD: integrating pivotal response treatment into video animation and physical model design

Huili She, Xinyi Dai, Ting Deng, Ruhao Liu, Wenting Jiang, Xufeng Ma

Background The integration of digital technology into art therapy for children with autism spectrum disorder (ASD) represents an emerging trend, yet systematic design frameworks that translate evidence-based interventions into digital media remain underdeveloped. This study developed and evaluated a digital art therapy paradigm that structurally integrates pivotal response treatment (PRT) into video animation design while maintaining cross-media consistency with physical generalization tools. Methods Based on the b …

26.08.2026journal-article

Radiation Sciences in Oncology

Artificial intelligence usage habits in radiation oncology: A survey for patients and caregivers

Ayben Yentek Balkanay, Ecem Demir

Objective: We aimed to evaluate the usage patterns, awareness, and trust in artificial intelligence (AI) technologies among radiation oncology patients and their caregivers. Materials and Methods: A total of 83 radiation oncology patients or caregivers were surveyed using a 17-item questionnaire. The survey assessed participant demographics, AI awareness, usage patterns, trust, verification behaviors, and concerns. Statistical analyses were conducted using Chi-square and Fisher’s exact tests. Results: Of 83 partici …

26.08.2026journal-article

Thoracic Cancer

Intraoperative Contrast‐Enhanced Ultrasonography (Io‐ CEUS ) to Detect Missed Lung Nodules During Robot‐Assisted Thoracoscopic Surgery

Alfonso Fiorelli, Antonio Marella, Marco Aiello, Valentina Brancato, Marco Salvatore, Daniela Comunale, Francesco Ferrigno, Gaetana Messina

ABSTRACT Herein, we reported the use of Intraoperative‐Contrast Enhanced Ultrasonography (Io‐CEUS) during Robotic Assisted Thoracic Surgery (RATS) for identification of malignant lung nodule that was missed during previous operation. Pre‐operative CT scan with 3D reconstruction defined the prompt position of the target lesion within S8 segment of right lower lobe and the anatomic landmarks as the distance from interlobar fissure and diaphragm. The lesion was then successfully detected by Io‐CEUS. The different arte …