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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

Angewandte Chemie

Boosting Diagnostic Accuracy of Prostate Cancer: Combining Clinical PSA Level and a Pair of NIR Fluorescent Probes for SLC39A1 and PSMA

Xiuzhu Huo, Fei Yang, Hong Wang, Jiao Chen, Mengyao She, Li Xue, Ping Liu, Shengyong Zhang, Jianli Li

ABSTRACT Prostate cancer (PCa) is a leading malignancy in men globally. Although serum prostate‐specific antigen (PSA) testing is prevalent for PCa screening, its inherent limitation in specificity and sensitivity frequently leads to high false‐positive and false‐negative diagnoses. To address this challenge, we present a PSA+ strategy that integrates a clinically defined PSA threshold (10 ng/mL) with a pair of complementary near‐infrared (NIR) fluorescent probes: a zinc‐complex‐based probe (Cy‐O‐NS‐a‐Zn) targeting …

26.08.2026journal-article

Nepal Journal of Public Health

Effectiveness of Multimodal Intervention on Health-Related Quality of Life And Treatment Adherence among Hypertensive Patients in Selected Community Of Jumla, Nepal

Anika Dahal, Kamal Prasad Acharya

Background: Hypertension continues to be a global health issue, with rates of prevalence rising quickly in both developed and developing nations. Adherence to or compliance with hypertensive medications has significant economic and therapeutic consequences because nonadherence patients are at greater risk of developing complications affecting their health status and overall quality of life. The research aimed to determine the effects of multimodal intervention on health related quality of life and treatment adheren …

26.08.2026journal-article

Cancer Research Communications

A Phase 1b/2 Study of Atezolizumab in Combination with Thiopurine Therapy in Patients with Metastatic Solid Tumors and Intermediate Tumor Mutational Burden

Christine Federspiel. Secher, Martin Højgaard, Iben Spanggaard, Ane Yde. Schmidt, Yuliu Guo, Luca Robinson, Daniela De Zio, Linea N. Toksvang, Frederik Otzen. Bagger, Kjeld Schmiegelow, Kristoffer S. Rohrberg

Abstract Purpose: The TEMPLE study was a phase 1b/2 trial evaluating the safety, tolerability, and efficacy of atezolizumab combined with thiopurine therapy in patients with metastatic solid tumors, aim-ing to increase tumor mutational burden (TMB) through single-nucleotide mismatching and neoepitope generation. Patients and Methods: Phase 1b was an open-label, single-arm dose de-escalation trial conducted to determine the recommended phase 2 dose (RP2D) of 6-mercaptopurine and 6-thioguanine combined with atezolizu …

26.08.2026journal-article

Frontiers in Oncology

Diagnostic accuracy of Node-RADS for lymph node metastasis in rectal cancer: a systematic review and meta-analysis

Tian Tian, Yang Li, Linfang Xu, Zhihua Lu

Objective To systematically evaluate the diagnostic accuracy and clinical value of the Node Reporting and Data System (Node-RADS) for lymph node metastasis in rectal cancer (RC). Methods The study followed PRISMA-DTA guidelines and was registered in PROSPERO (CRD420261372147). PubMed, Embase, Web of Science, Cochrane Library, CNKI, Wanfang, VIP, and the Chinese Biomedical Literature Database were searched from inception to April 2026. Two reviewers independently screened studies, extracted data, and assessed method …

26.08.2026journal-article

Journal of modern medicine

METHOD FOR SELECTING AND TECHNICAL ASPECTS OF SURGICAL TREATMENT FOR INFECTED PANCREATIC NECROSIS IN PATIENTS WITH DIABETES MELLITUS

N.A. Kasimov, D.M. Khakimov, G.M Khojimatov, Kh.Kh Khamdamov

<p>The scientific article presents methods and technical techniques for choosing surgical tactics for infected pancreatic necrosis (IPN) in patients with diabetes mellitus (DM). Clinical trials were conducted on 188 patients with IPN who underwent treatment at the RSCEMP AB between 2012 and 2025. Depending on the period and presence of DM, all included patients were divided into 3 groups. The control group consisted of 62 (33%) patients with IPN against the background of DM who underwent treatment in 2012-2018, whi …

26.08.2026journal-article

Nursing Edição Brasileira

Tumor de Wilms: Características Histopatológicas

Dener Hayek de Miranda, Roberta Wassita Curi Schumann Rosso

O tumor de Wilms, ou nefroblastoma, representa a neoplasia renal maligna mais frequente na infância, originando-se de remanescentes nefrogênicos embrionários. Sua complexidade histológica é um dos seus aspectos mais marcantes, caracterizando-se por uma tríade clássica composta por elementos blastemais, epiteliais e estromais, que podem se apresentar em diversas proporções e graus de diferenciação. A classificação histopatológica desempenha um papel determinante no prognóstico e na estratificação de risco, distingui …

26.08.2026journal-article

Health Science Reports

Colorectal Cancer and Intestinal Protozoan Infections: Prevalence, Risk Factors, and Molecular Confirmation in Western Iran: A Descriptive Case‐Control Study

Alireza Moayyedkazemi, Amal Khudair Khalaf, Sima Nik Khah Behnamiri, Asghar Sepahvand, Neda Niazi, Maryam Sepahvand, Hossein Mahmoudvand

ABSTRACT Background and Aims Infections are recognized contributors to cancer development. This study aimed to assess the prevalence, socio‐demographic characteristics, and risk factors associated with intestinal protozoan parasites in patients with colorectal cancer (CRC) in Western Iran. Methods This descriptive case‐control study enrolled 174 CRC patients and 174 non‐CRC healthy controls receiving care at general hospitals in Lorestan Province between October 2022 and August 2024. Fresh stool samples were examin …

26.08.2026journal-article

N.N. Priorov Journal of Traumatology and Orthopedics

Sciatic Nerve Stimulation in the treatment of post-traumatic sciatic neuropathy. A systematic review.

Viktor P. Kondratev, Andrew V. Dekopov, Emil D. Isagulyan, Alexey A. Tomskii

Despite the clinical relevance of sciatic nerve injuries, there is a lack of consolidated evidence on the effectiveness of peripheral nerve stimulation. The review included seven original studies published last 10 years, selected according to PRISMA guidelines, focusing on pain relief (assessed via VAS) and functional recovery (evaluated using MRC, ODI, and other scales). The results demonstrated a significant reduction in pain intensity (43–86%) in stimulation groups compared to controls. However, data on muscle s …

26.08.2026journal-article

Journal of Phytomedicine

Multi-Target Pharmacological Mechanisms of Cannabidiol in Breast, Colorectal, and Lung Cancer: An Integrated Network Pharmacology and Molecular Docking Study

Marlon C. Mallillin, Arkapravo Chattopadhyay, Irish Mhel C. Mitra, Omar A. Villalobos, Shengnan Zhao, Maryam Salami, Nádia Araci Bou-Chacra, Gabriel Lima de Barros Araújo, Khaled Barakat, Raimar Löbenberg, Neal M. Davies

Cannabidiol (CBD), the principal non-psychoactive phytocannabinoid of Cannabis sativa, exhibits diverse pharmacological activities through interactions with multiple molecular targets. Thus, breast, colorectal, and lung cancers arise from distinct molecular mechanisms. This study investigated the potential multi-target pharmacological mechanisms of CBD using an integrated approach combining network pharmacology and molecular docking. CBD-associated targets from three prediction platforms were intersected with disea …

26.08.2026journal-article

Journal of Palliative Medicine

A Comparative Pilot Survey of Kratom Utilization by Cancer and Non-Cancer Consumers

Jace Hubley, Saunjoo L. Yoon, Oliver Grundmann

Background: Kratom, an analgesic and mood-altering herbal product from Southeast Asia, has gained popularity and is used for self-treatment purposes in the United States. Objective: To evaluate the utilization of kratom by cancer patients compared to those without a cancer diagnosis. Methods: An anonymous online survey was distributed to evaluate demographic, primary beneficial, and detrimental effects relative to cancer diagnosis, quality of life, and kratom use patterns. The final sample included 136 respondents …

26.08.2026journal-article

Cancer Research Communications

Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small-Cell Lung Cancer

Chiori Tabe, Rajesh Kumar, Yue Huang, Michael J. Kruhlak, Ajit Kumar. Sharma, Roshan L. Shrestha, Anish Thomas

Abstract Small-cell lung cancer (SCLC) is characterized by pervasive chromosomal instability (CIN) and remains largely refractory to targeted therapies. KIF18A, a motor protein that regulates chromosome alignment during mitosis, has emerged as a selective dependency in CIN-high tumors. Whether this dependency extends to SCLC, a prototypical CIN-high cancer, has not been established, and biomarkers predicting response to KIF18A inhibition, currently in clinical trials, are lacking. We integrated analyses of patient …

26.08.2026journal-article

Frontiers in Oncology

Case Report: Synergistic potential of RANKL and ACLY inhibition in a breast cancer patient with acquired resistance to CDK4/6 inhibitors

Anastasiia Samusieva, Ielizaveta Gorodetska, Oleg Socha, Yuliia Lytovchenko, Roman Kisielov, Borys Dons`koi, Daria Kozeretska, Vasyl Lukiyanchuk, Anna Dubrovska, Valeriy Cheshuk, Olga Ponomarova, Iryna Kozeretska

Background The development of acquired resistance to cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) represents a major clinical challenge in the management of hormone receptor-positive (HR+), human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer. Overcoming this resistance requires novel therapeutic strategies that target the underlying molecular escape pathways. Case presentation We report the case of a patient initially diagnosed in 2011 with pT2N0M0, ER+/HER2- invasive ductal carcin …

26.08.2026journal-article

Frontiers in Oncology

Sex-based analysis of first-line immune-based combinations in intermediate/poor-risk papillary, chromophobe, and unclassified renal cell carcinoma: an ARON-1 subanalysis

Paola I. Valdez-Sandoval, Evelyn L. Beas-Lozano, Zin W. Myint, Jakub Kucharz, Veronica Mollica, Alessandro Rizzo, Tarek Taha, Johannes Landmesser, Esther Pérez Calabuig, Jawaher Ansari, Cinzia Ortega, Ravindran Kanesvaran, Dipen Bhuva, Anca Zgura, Ondrej Fiala, Javier Molina-Cerrillo, Sebastiano Buti, Francesco Massari, Maria Fernanda Esparza-Orozco, Matteo Santoni, Maria T. Bourlon

Background Non-clear cell renal cell carcinoma (nccRCC) represents a heterogeneous group of malignancies with limited prospective data to guide systemic therapy. Immune-based combination regimens are increasingly used in this setting by extrapolation from clear cell RCC trials. Whether patient sex influences outcomes in metastatic nccRCC treated with first-line immunotherapy (IO)-based combinations remains unknown. Methods This is a retrospective sub-analysis of the ARON-1 real-world study that included 256 patient …

26.08.2026journal-article

OSMANGAZİ JOURNAL OF MEDICINE

Symptom Burden and Quality of Life by Lymphedema Stage After Breast Cancer

Çağrı Akalın

Breast cancer-related lymphedema (BCRL) is a chronic condition that contributes to symptom burden and impairs quality of life. This single-center cross-sectional study evaluated the association between the clinical stage of lymphedema, patient-reported symptom burden, and quality of life in 63 patients with BCRL. Lymphedema stage was classified according to the International Society of Lymphology (ISL) criteria, with 11 patients (17.5%) in Stage I, 39 (61.9%) in Stage II, and 13 (20.6%) in Stage III. Symptom burden …

26.08.2026journal-article

BJU International

Identifying the ideal candidate for irreversible electroporation in localized prostate cancer: a comprehensive narrative review from the EAU Section of Endourology

Raffaele La Mura, Giuseppe Maiolino, Julien Anract, Massimo Valerio, Clement Orczyk, Ben Vanneste, Federico Zorzi, João Paulo Barbosa de Oliveira, Juan Ignacio Martínez‐Salamanca, Eric Barret

Background and Objective Irreversible electroporation (IRE) is an emerging non‐thermal focal therapy for localized prostate cancer (PCa), offering tissue‐selective ablation with functional preservation. This review aimed to delineate the ‘ideal’ candidate for primary IRE and provide practical guidance. Methods A narrative review (2014–2025) of primary IRE for localized PCa was conducted, including prospective series, multicentre registries, comparative studies, and systematic reviews. We synthesized baseline charac …

26.08.2026journal-article

Manufacturing & Service Operations Management

Heterogeneous Treatment Effects in Panel Data: Insights into the Healthy Incentives Program

Retsef Levi, Elisabeth Paulson, Georgia Perakis, Emily Zhang

Problem definition: We study how adding new vendors to the Massachusetts Healthy Incentives Program (HIP), a food subsidy program, affects program utilization. This is an instance of a core problem in causal inference: estimating heterogeneous treatment effects (HTEs) using panel data. Existing methods either do not utilize the underlying structure in the panel data or do not accommodate the general vendor addition patterns in the HIP data. Methodology/results: We propose the panel clustering estimator (PaCE), a no …

26.08.2026journal-article

Genes & Development

Architectural logic of the 3D genome: mechanisms of dysregulation and emerging cancer therapeutics

Rebecca G. Smith, Hannah M. Wilson, Kathleen L. Schiela, Yu Liu

The three-dimensional (3D) genome provides an essential layer of organization that shapes genome function in space and time. Chromatin compartments and topologically associating domains (TADs) arise from the interplay between intrinsic properties of chromatin and architectural factors, including cohesin and CTCF. Despite substantial progress in defining these structural features, whether 3D genome architecture plays a causal role in regulating processes such as transcription, DNA replication, and DNA repair, or ins …

26.08.2026journal-article

DEN Open

Early Gastric Cancer Detected During 15‐year Surveillance After Ménétrier Disease Remission and Successfully Treated With Endoscopic Submucosal Dissection: A Case Report

Takaaki Shamoto, Hideko Yamamoto, Takehito Naito, Masahiro Yamada, Hirotaka Suzuki, Emiko Hida, Takafumi Yamamoto, Yoshifumi Arai, Hiroshi Matsubara

ABSTRACT Ménétrier disease (MD) was diagnosed based on hypoalbuminemia and giant gastric folds extending from the body to the fundus in a woman in her 70s. A serum anti‐ Helicobacter pylori antibody test and urea breath test yielded negative results. Remission was achieved with steroid therapy, and she was relapse‐free with the use of a proton pump inhibitor. Annual esophagogastroduodenoscopy (EGD) was continued for gastric cancer surveillance. Fifteen years after the diagnosis of MD, a type 0‐I well‐differentiated …

26.08.2026journal-article

International Journal of Contemporary Pediatrics

3% saline versus mannitol in the treatment of cerebral edema in children: a randomized controlled trial

Misbah Sultana S., Rizwan U. Zama, Naushad Malagi

Background: Cerebral edema with raised intracranial pressure is a pediatric neurological emergency associated with coma, herniation and death. Mannitol and hypertonic saline are commonly used osmotic agents, but comparative pediatric data remain limited and heterogeneous. To compare the efficacy and safety of 3% hypertonic saline with 20% mannitol in children aged 3 months to 12 years with cerebral edema. Methods: This randomized controlled trial was conducted from 2023 to 2025 among 70 children with clinical or ra …

26.08.2026journal-article

Revista ft

Massofilaxia facial e LED vermelho associados à nanotecnologia no tratamento da flacidez tissular

Erilaine Batista Quintiliano de Lima, Daiana da Silva Granja Amorim, Juliana Barbosa de Sena Silva, Luena Maria Moraes Trindade, Luciana de Almeida Ferreira

Skin aging is a complex biological phenomenon resulting from the interaction between intrinsic factors, related to the body’s natural aging process, and extrinsic factors, such as exposure to ultraviolet radiation, environmental pollution, unhealthy lifestyle habits, and oxidative stress. These conditions promote structural changes in the skin, including the degradation of collagen and elastin fibers, reduced tissue regeneration capacity, and impairment of barrier function, resulting in wrinkles, laxity, loss of el …

26.08.2026journal-article

Haemophilia

Five‐Year Longitudinal Changes in Treatment Strategies and Clinical Outcomes in Adults With Haemophilia: The ADVANCE Japan Cohort Study

Azusa Nagao, Akihiro Sawada, Takeshi Kanematsu, Naoya Yamasaki, Hideyuki Takedani, Masanori Nojima, Yukio Hiroi, Teruhisa Fujii, Nobuaki Suzuki, Tadashi Matsushita, Satoshi Higasa, Kagehiro Amano, Yushi Chikasawa

ABSTRACT Background Prophylactic treatment for haemophilia has evolved with the introduction of extended half‐life (EHL) and nonfactor products. However, long‐term real‐world data describing how these advances have affected adults with haemophilia remain limited. Objectives To evaluate 5‐year changes in treatment strategies and clinical outcomes in adults aged ≥40 years with haemophilia. Methods We analyzed 5‐year longitudinal data from ADVANCE Japan, a nationwide prospective registry of adults aged ≥40 years with …

26.08.2026journal-article

Journal of Adolescent and Young Adult Oncology

Delivery of Guideline Concordant Supportive Care for AYAs with Cancer in a Statewide Population-Based Cohort

Jacob N. Stein, Christopher D. Baggett, Emily R. Haines, Nicole Knape, Jennifer L. Lund, Hannah C. Winslow, KyungSu Kim, Jordan Lodato Hunt, Alison Manikowski, Catherine Habashy, Andrew B. Smitherman, Katherine E. Reeder-Hayes

Purpose: In the past two decades, there has been a growing recognition of the unique needs of adolescent and young adult (AYA) cancer patients. Alongside this recognition is the emergence of guidelines for high-quality AYA cancer care. Despite such tailored guidelines, preliminary studies suggest a gap between recommended versus received care among AYAs. We sought to examine patterns in receipt of guideline-concordant care among this population using a state-wide claims database. Methods: We conducted a retrospecti …

26.08.2026journal-article

Russian Bulletin of Obstetrician-Gynecologist

Comparison of laparoscopic and robot-assisted approaches in the surgical treatment of patients with endometrial cancer and morbid obesity. Preliminary results

A.A. Popov, Yu.V. Senkina, I.D. Klyushnikov, T.A. Glebov, O.Yu. Rebrova, A.R. Fattakhov

Endometrial cancer ranks 2nd after cervical cancer in the structure of oncogynecological diseases worldwide and 1st in economically developed countries. Among patients with endometrial cancer, the incidence of concomitant obesity can reach 60%. Minimally invasive techniques such as laparoscopic or robot—assisted approaches are often used in the treatment of patients with endometrial cancer, especially patients with morbid obesity. Compared to traditional open surgery, these approaches can reduce the risk of complic …

26.08.2026journal-article

Physics in Medicine & Biology

A programmable electroculture platform for direction-dependent alternating electric field delivery in cancer cell models

Fatih Senturk, Ismail Cengiz Kocum, Eda Sevval Aksan, Ugur Duzen

Abstract Objective. Alternating electric fields (AEFs) at intermediate frequencies have been shown to disrupt mitosis and inhibit the proliferation of rapidly dividing tumor cells. Here, we developed a programmable in vitro AEF exposure system (0–500 kHz, 1–3 V cm −1 ) featuring an electroculture platform compatible with standard 12-well tissue culture plates. The system enables investigation of cellular responses to fixed orthogonal field orientations and periodic polarization switching (PPS), defined as sequentia …