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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Frontiers in Medicine

Aggregate index of systemic inflammation and glaucoma status: population-based evidence with clinical validation

Songxin Yang, Li Li, Xianming Ouyang, Rui Zhang, Gang Lin, Sunkun Pan, Guiquan Xie, Zhen Lv, Dieran Huang, Guoyan Luo, Kunpeng Pang

Objective Glaucoma is a major cause of irreversible visual impairment, but evidence on the association between the aggregate index of systemic inflammation (AISI) and glaucoma remains limited, particularly with clinical validation. Methods We analyzed National Health and Nutrition Examination Survey (NHANES) data from participants aged 40 years and older. Weighted multivariable logistic regression models were used to examine the association between AISI and glaucoma. The primary outcome was composite glaucoma, defi …

27.08.2026journal-article

Frontiers in Medicine

Reduced heart rate variability is associated with disease severity in AL amyloidosis: a retrospective cohort study

Xiao-hang Pei, Su-qiong Zuo, Pan Zhou, Rong-jun Ma, Zun-min Zhu, Xiao-li Yuan

Background Autonomic nervous system involvement is common in systemic amyloidosis, yet the clinical relevance of heart rate variability (HRV) in immunoglobulin light-chain (AL) amyloidosis remains incompletely defined. Methods In this retrospective cohort study, 56 patients with biopsy-proven AL amyloidosis and 33 age- and sex-comparable healthy controls underwent 24 h Holter monitoring. Time- and frequency-domain HRV parameters were recorded. Associations of HRV with cardiac involvement assessed by cardiac magneti …

27.08.2026journal-article

The Canadian Journal of Chemical Engineering

A target‐adaptive latent‐temporal ensemble soft sensor for robust multi‐effluent quality prediction in full‐scale wastewater treatment plants

Toqeer Ahmed, Abid Aman, Zhenjun Ge, Yiqi Liu

Abstract Real‐time prediction of effluent quality is essential for stable wastewater treatment plant (WWTP) operation, but direct laboratory measurements of chemical oxygen demand (CODe), total nitrogen (TNe), and total phosphorus (TPe) are often delayed and discontinuous. This study proposes a target‐adaptive latent‐temporal ensemble soft‐sensing framework, named the hybrid latent‐temporal ensemble network (HEM‐Net), for simultaneous multi‐effluent quality prediction in a full‐scale wastewater treatment plant. The …

27.08.2026journal-article

Australian Health Review

Concordance of surveillance colonoscopy recommended intervals with Australian guidelines: a clinical audit in six Victorian public hospitals

Jonathan Foo, Corey Joseph, Alexandra Gorelik, Martin Hensher, Harriet Hiscock, Alison Hutchinson, Karin A. Thursky, Ralph Audehm, Andrew O'Loughlin, Grant Russell, Alan Moss, Elizabeth Hristov, Kumanan Nalankilli, Radha Nair, Anne Van Berkel, Sophie Ping, Jaclyn Bishop, Judi Debney, Kirsten Carr, Julianne Schultz, Denise A. O'Connor

Objective Appropriate intervals for repeat (surveillance) colonoscopy are important for early colorectal cancer detection and treatment, timely patient access, and minimising patient risks. This study aimed to assess the concordance of endoscopist-recommended surveillance colonoscopy intervals with those recommended by the 2018 Australian Cancer Council surveillance colonoscopy guidelines. Methods Three metropolitan and three rural public hospitals in Victoria, Australia, each retrospectively audited at least 35 co …

27.08.2026journal-article

Advances in Anesthesia and Pain Medicine

Low-concentration dual-baricity thoracic segmental spinal anesthesia for laparoscopic cholecystectomy: a retrospective case series

Paolo Scimia, Massimiliano Luca D'Agostino, Antonio De Cato, Franco Marinangeli, Simone Cicconi, Riccardo Moretti, Federica Venturoni, Fabrizio Fattorini, Roberto Starnari, Domenico Pietro Santonastaso, Luca Gentili

Laparoscopic cholecystectomy (LC) is usually performed under general anesthesia (GA), which provides airway protection and optimal surgical conditions but may expose vulnerable patients to cardiopulmonary stress and other anesthesia-related adverse effects. Thoracic segmental spinal anesthesia (TSSA) may represent an alternative in selected patients. We evaluated the feasibility, safety, and perioperative outcomes of a low-concentration dual-baricity TSSA protocol for LC. This retrospective descriptive case series …

27.08.2026journal-article

Journal of Intensive Care Medicine

Development and Validation of an Interpretable Machine Learning Model for Predicting In-Hospital Mortality in Diabetic Patients with Sepsis-Associated Acute Kidney Injury

Yanni Wang, Hongjie Shen, Shengze Wu, Suibi Yang, Feng Guo, Min Yang, Zhongheng Zhang

Background Sepsis-associated acute kidney injury (SA-AKI) is a common and severe complication in critically ill patients, with poor prognosis. Diabetes may further increase adverse outcomes through infection susceptibility, immune dysfunction, and renal vulnerability. However, mortality prediction models for patients with diabetes complicated by SA-AKI remain limited. This study aimed to develop and validate a machine learning-based model for early in-hospital mortality prediction in this population. Methods A tota …

27.08.2026journal-article

Clinical Kidney Journal

Managing hyponatremia: fast or slow? why, when, how, and controversies

Kamel S Kamel, Ziv Harel, Martin Schreiber

Abstract Hyponatremia is the most common electrolyte disorder encountered in clinical practice. Its management is challenging because treatment must balance the risk of cerebral edema in acute hyponatremia against the risk of osmotic demyelination syndrome (ODS) from overly rapid correction of chronic hyponatremia. Recent observational studies have questioned current correction limits, prompting renewed debate regarding optimal management. This narrative review presents a physiology-based approach to the evaluation …

27.08.2026journal-article

Clinical Science

Maternal gut microbiota–psychotropic drug interactions and their impact on offspring neurodevelopment

Ashlee M. Craig, Kelly J. Clemens, Sarah-Jane Leigh

Abstract Pregnancy is associated with a unique and dynamic gut microbiota profile that supports fetal growth and neurodevelopment. Psychotropic drug–gut microbiota interactions are documented in the general population, yet less well described in pregnant women. Research has independently linked both perinatal psychotropic exposure and alterations to the maternal gut microbiome with potential changes to offspring neurodevelopment; therefore, it is plausible that similar interactions occur during pregnancy where they …

27.08.2026journal-article

Frontiers in Surgery

Laryngeal transplantation: from experimental feasibility to multidisciplinary clinical reality

Lu Zeng, Longhao Wang

Laryngeal transplantation represents one of the most complex forms of vascularized composite allotransplantation (VCA), aiming to restore respiration, phonation, and swallowing in patients with irreversible laryngeal dysfunction. Over the past decades, systematic preclinical research—including refinement of large-animal and rodent models, organ preservation optimization, and elucidation of immunological mechanisms—has laid the scientific foundation for clinical translation. Advances in static cold storage, emerging …

27.08.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Determinants of Treatment Adherence in Hepatitis C Patients in a Public Sector Setting in India

Sunvir Kaur Rai, Harpreet Singh, Simmi Oberoi, Amandev Singh, Rahul Bhargava

ABSTRACT. The National Viral Hepatitis Control Program has rapidly scaled hepatitis C virus (HCV) treatment. However, poor adherence and loss to follow-up have led to drug resistance, treatment failure, and increased healthcare costs. Given this background, the present study was conducted to evaluate the rate of loss to follow-up, assess adherence patterns to treatment, and identify factors associated with both of these among HCV patients. A prospective cohort study was conducted among 385 adult HCV patients at Gov …

27.08.2026journal-article

Molecular Medicine

Short-chain fatty acids as key mediators of the microbiota–gut–brain axis in chronic cerebral hypoperfusion: mechanisms and therapeutic

Junchen Si, Peijian Wang, Zhongchen Li, Jiheng Hao, Jiyue Wang, Liyong Zhang

Abstract Chronic cerebral hypoperfusion (CCH) is an important contributor to vascular cognitive impairment and neurodegenerative disorders, characterized by neuronal injury, blood–brain barrier (BBB) disruption, neuroinflammation, mitochondrial dysfunction, and synaptic impairment. Increasing evidence suggests that the microbiota–gut–brain axis plays a crucial role in ischemic brain injury. CCH is associated with gut microbiota dysbiosis, intestinal barrier dysfunction, and reduced production of microbiota-derived …

27.08.2026journal-article

Frontiers in Pediatrics

Evaluating the effectiveness of an educational curriculum on physician comfort in screening and managing eating disorders in the outpatient pediatric setting

Xhesika Begaj, Elena Lorenzana, Stephanie Marcy, Colleen Kraft

Background Eating disorders are among the most prevalent chronic conditions affecting adolescents, yet remain underdiagnosed in outpatient pediatric settings. Physician discomfort with screening and management contributes to this gap, particularly in underserved communities. This study evaluated whether a structured educational curriculum paired with an EMR-integrated clinical decision support tool improves physician comfort with eating disorder screening and management, and increases screening behavior, in an outp …

27.08.2026journal-article

Asia-Pacific Journal of Clinical Oncology

Advancing Homologous Recombination Repair Mutation Testing in Prostate Cancer in Australia: Shifting the Focus to Hormone Sensitive Prostate Cancer

Arun A. Azad, Declan G. Murphy, Edmond M. Kwan, Anthony M. Joshua

ABSTRACT Homologous recombination repair (HRR) gene alterations are key drivers of disease in prostate cancer. This has led to great interest in HRR targeted therapies, particularly polyadenosine diphosphate‐ribose inhibitors (PARPi), in the treatment of metastatic castrate resistant prostate cancer (mCRPC). HRR alterations are typically early events in prostate cancer tumorigenesis. As a result, clinical trials are investigating the efficacy of PARPi therapy in metastatic hormone sensitive prostate cancer (mHSPC). …

27.08.2026journal-article

The Journal of Clinical Endocrinology & Metabolism

Effects of Semaglutide versus Bariatric Surgery on Noninvasive Markers of Hepatic Steatosis and Fibrosis in Obesity with MASLD

Paula Lünswilken, Katarzyna Worobiec, Lara S Braun, Julia Altrogge, Andrea Schenk, Lina Jegodzinski, Britta Wilms, Jens U Marquardt, Svenja Meyhöfer

Abstract Aims Obesity is a key driver of metabolic dysfunction-associated steatotic liver disease (MASLD). Beyond lifestyle modification, pharmacological and surgical therapies were recently established. This study compared the effects of lifestyle therapy, lifestyle plus semaglutide, and bariatric surgery on non-invasive markers of hepatic steatosis and fibrosis. Materials and Methods In this single-center, prospective, observational cohort study, ninety-two adults with obesity were analyzed over 72 weeks. Patient …

27.08.2026journal-article

Frontiers in Medicine

Research progress of cerebroplacental ratio in obstetric complications

Xinran Bi, Ruotong Qi, Haiying Chen

Cerebroplacental ratio (CPR), defined as fetal middle cerebral artery pulsatility index (MCA-PI)/umbilical artery pulsatility index (UA-PI), quantifies intrauterine hemodynamic redistribution driven by the fetal brain-sparing response to placental insufficiency. With the advancement of ultrasonic technology and in-depth clinical research, CPR has been widely applied in early screening, condition assessment, prognosis evaluation and intervention guidance of various obstetric complications, especially showing unique …

27.08.2026journal-article

Neurology and Clinical Neuroscience

Early and Unusual Restenosis Following Carotid Endarterectomy for Symptomatic Carotid Web: A Case Report

Haruki Hoshikawa, Yasuhisa Akaiwa, Yoshiyuki Matsumoto, Issei Takano, Kensuke Suzuki, Kohei Miyagawa, Toshiki Nakamura, Mari Tada, Tomoyuki Miyamoto

ABSTRACT A 52‐year‐old man presented with acute motor aphasia. Brain MRI revealed embolic infarctions in the left middle cerebral artery territory. CT angiography and carotid ultrasonography demonstrated a shelf‐like projection arising from the posterior wall of the left carotid bulb, consistent with a carotid web (CW). Transcranial Doppler ultrasonography detected microembolic signals, supporting the diagnosis of artery‐to‐artery embolism associated with the CW. Carotid endarterectomy (CEA) was performed to preven …

27.08.2026journal-article

Journal of Clinical Oncology

Refined Continuous Risk Index for Accurately Predicting Outcomes of Patients With Chronic Lymphocytic Leukemia After Limited-Duration Therapy

Othman Al-Sawaf, Can Zhang, Mohammad S. Esfahani, Chih Long Liu, Sandra Robrecht, Eugen Tausch, Anke Schilhabel, Matthias Ritgen, Christof Schneider, Martin Peifer, Moritz Fürstenau, Carsten Utoft Niemann, Arnon P. Kater, John F. Seymour, Brenda Chyla, Yanwen Jiang, Barbara Eichhorst, Stephan Stilgenbauer, Michael Hallek, Ash A. Alizadeh, David M. Kurtz, Kirsten Fischer

PURPOSE Measurable residual disease (MRD) status after limited-duration treatment for chronic lymphocytic leukemia (CLL) strongly predicts survival times and is considered a surrogate end point. However, most prognostic indices, including the International Prognostic Index (CLL-IPI), rely solely on pretreatment features. To incorporate dynamic MRD data in prognostic models, the continuous individualized risk index (CIRI) was proposed in 2019. Since developed in the context of chemoimmunotherapy, we here propose a r …

27.08.2026journal-article

Research, Society and Development

Terapias biológicas na rinossinusite crônica grave com pólipos nasais: Eficácia, segurança e impacto sobre a necessidade de cirurgia e corticosteroides sistêmicos

Maria Clara Peres de Castelo Branco, Jordana Magda da Silva Castro, Maria Vitória Lino Machado, Eduarda Moura dos Santos, Alana Granda Mendonça, Júlia Pires Silva, Maria Flávia Rigonato Lima

A rinossinusite crônica grave com pólipos nasais (RSCcPN) apresenta elevada carga sintomática, recorrência frequente e, em parte dos pacientes, necessidade repetida de corticosteroides sistêmicos e procedimentos cirúrgicos. Este estudo teve como objetivo analisar as evidências disponíveis sobre a eficácia e a segurança das terapias biológicas utilizadas na RSCcPN, com ênfase na carga polipoide, sintomas, função olfatória, qualidade de vida e redução da necessidade de corticosteroides sistêmicos e cirurgia. Foi real …

27.08.2026journal-article

Exploration of Musculoskeletal Diseases

Hypophosphatasia: current concepts in diagnosis and management of a rare metabolic disorder

Maritza Vidal, Tiara Gill, Richard Keen, Judith Bubbear

Hypophosphatasia (HPP) is a rare inherited metabolic disorder caused by deficient activity of tissue non-specific alkaline phosphatase (TNSALP). The resulting accumulation of its substrates, particularly inorganic pyrophosphate (PPi) and pyridoxal-5-phosphate (PLP), impairs skeletal and dental mineralization and disrupts vitamin B6 metabolism, contributing to multisystem manifestations. The clinical spectrum is highly heterogeneous, ranging from severe, life-threatening forms in the perinatal period to milder muscu …

27.08.2026journal-article

Molecules

Beneficial Role of Quercetin in Prevention and Treatment of Ischemic Stroke: Mechanisms of Action and Administration Strategies

Aleksandra Szychowska, Mikołaj Grabarczyk, Weronika Szczepańska, Ewa Smolińska, Andrzej Glabinski, Piotr Szpakowski

Polyphenols are a complex class of plant secondary metabolites that exert numerous beneficial effects on human health. The content of individual polyphenolic compounds varies considerably among plant species. Over the past few decades, polyphenols have attracted increasing interest because of their antioxidant and antimicrobial properties. They have also demonstrated beneficial effects in the prevention and treatment of various diseases, including cardiovascular and nervous system disorders, as well as different ty …

27.08.2026journal-article

ARACÊ

INFECÇÃO PELO VÍRUS EPSTEIN-BARR EM PACIENTES COM LEUCEMIA LINFOCÍTICA CRÔNICA: PREVALÊNCIA, REPERCUSSÕES CLÍNICAS E IMPLICAÇÕES PARA O MANEJO

Vitória Nazaré Costa Seixas, Elzelis Muller Da Silva, Thiago Nicolau Magalhães de Souza Conte, Rosemary Maria Pimentel Coutinho, Vera Regina da Cunha Menezes Palácios, Patrícia Danielle Lima De Lima

A leucemia linfocítica crônica (LLC) é uma neoplasia hematológica caracterizada pelo acúmulo de linfócitos B clonais e por importante comprometimento imunológico, que aumenta a suscetibilidade a infecções e complicações relacionadas ao tratamento. Nesse contexto, o vírus Epstein-Barr (EBV), capaz de estabelecer infecção persistente e permanecer em estado de latência nos linfócitos B, apresenta potencial relevância clínica, especialmente em situações de imunossupressão. Este estudo teve como objetivo revisar a liter …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Predictors of the technical success of ultrasound-guided percutaneous transhepatic biliary drainage for biliary obstruction

Yun Song, Guang-Hai Chen, Lu Peng, Jian Du, Shu-Ming Tan

BACKGROUND Percutaneous transhepatic biliary drainage (PTBD) is a critical minimally invasive intervention for biliary obstruction, with technical success being a key determinant of clinical outcomes. AIM To identify and quantify the clinically modifiable factors predicting technical success of ultrasound-guided PTBD, and thereby to develop an evidence-based framework for procedural triage and standardization. METHODS A total of 263 ultrasound-guided PTBD procedures performed at three tertiary hospitals (2019-2024) …

27.08.2026journal-article

Frontiers in Public Health

Psychological capital, perceptions of clinical stressors, and bullying experiences among Chinese nursing students during clinical practice: a latent profile and mediation analysis

Fangfei Zhao, Hongchen Zhang, Ke Hui, Haixin Zheng, Zhihui He

Background Bullying experiences during clinical practice threaten nursing students' learning and professional development. However, existing studies mainly focused on variable-centered associations, with limited exploration of heterogeneous subgroups from a person-centered perspective. This study aimed to examine the mediating role of perceptions of clinical stressors (PCS) in the relationship between psychological capital (PsyCap) and bullying experiences, while identifying latent profiles of bullying experiences. …

27.08.2026journal-article

Evolution, Medicine, and Public Health

Running wild: Forest running enhances performance, enjoyment, mood and future exercise intentions

Matthew J Putland, Stephen J Bailey, Bryna C R Chrismas, Stacy Clemes, Morgan Ewers, Yu-Ling Ho, Eloise Jones, Adelina Lintuluoto, Kirsten McEwan, Riddhi Naik, Hanna Lal Rahimi, Hongbin Xiang, Erik P Willems, Colin N Shaw, Daniel P Longman

ABSTRACT Background and objectives Physical inactivity remains widespread despite the well-established physical and mental health benefits of regular physical activity (PA). There is an urgent need for strategies that increase both uptake and long-term adherence. The Environmental Mismatch Hypothesis proposes that natural environments may increase both engagement and performance of PA. Methodology Forty-seven healthy adults (16 females) completed a randomised, counterbalanced crossover trial. Participants undertook …