Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Onkologie · Seite 62

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
25.08.2026journal-article

Journal of Medical Genetics

Risk of breast cancer after ovarian cancer in germline BRCA1/2 heterozygotes

Robert D Morgan, Emma R Woodward, D Gareth Evans

Breast cancer risk after ovarian cancer in germline BRCA1/2 heterozygotes remains uncertain, with a recent large multicentre international study reporting lower-than-expected incidence in the first decade after ovarian cancer diagnosis (Apostol et al. 2026). We re‑evaluated our previously published regional cohort of 701 women with ovarian cancer and a germline BRCA1/2 pathogenic or likely pathogenic variant, restricting the analysis to those tested after ovarian cancer diagnosis and without prior breast cancer, to …

25.08.2026journal-article

Journal of Clinical Oncology

Becotatug Vedotin Combined With Pucotenlimab in Platinum- and Immunotherapy-Resistant Recurrent or Metastatic Nasopharyngeal Carcinoma

Dan-Yun Ruan, Feng-Hua Wang, Yujuan Zhou, Yanqun Xiang, Jinguan Lin, Lin Liu, Ping Liu, Linquan Tang, Yuxiang Ma, Tao Hou, Qiuyan Chen, Zhi-Ming Li, Fei Han, Song Qu, Sufang Qiu, Chen Han, Hongzhi Ma, Fang Su, Jin Gao, Ye Guo, Zheng Wu, Hai-Jun Wu, Yanqiu Zhao, Meiyu Fang, Man Hu, Yuan Wu, Shuo Cui, Mengyun Li, Qiong Zhao, Rui-Hua Xu

PURPOSE Patients with recurrent or metastatic nasopharyngeal carcinoma (R/M NPC) have limited therapeutic options after failing platinum and anti–PD-1/PD-L1 therapy. We investigated the efficacy and safety of an epidermal growth factor receptor (EGFR)–directed antibody-drug conjugate (ADC) becotatug vedotin (BV) combined with a PD-1 inhibitor pucotenlimab in this setting of patients. MATERIALS AND METHODS Magic-C001 (ClinicalTrials.gov identifier: NCT05688605 ) is an ongoing, open-label, multicohort, dose escalatio …

25.08.2026journal-article

Cancer

Vimseltinib for patients with tenosynovial giant cell tumor: A multicenter, open‐label, phase 2 trial

Silvia Stacchiotti, Jean‐Yves Blay, Piotr Rutkowski, Hans Gelderblom, Alejandro Falcón, Axel Le Cesne, Jayesh Desai, Emanuela Palmerini, César Serrano, Kristen N. Ganjoo, Gina Z. D’Amato, Christopher W. Ryan, Breelyn A. Wilky, Virginia Ferraresi, Ramy Saleh, Vinod Ravi, Albiruni Abdul Razak, Antonio Casado Herráez, Mahbubl Ahmed, Nicholas M. Bernthal, Michiel van de Sande, Mehdi Brahmi, Bartlomiej Szostakowski, Jasmine Sen, Nicholas A. Zeringo, Brooke Harrow, Supraja Narasimhan, Amanda Saunders, Maitreyi G. Sharma, Matthew L. Sherman, Andrew J. Wagner, William D. Tap

Abstract Background Tenosynovial giant cell tumor (TGCT) is a locally aggressive neoplasm caused by dysregulation of the colony‐stimulating factor 1 ( CSF1 ) gene. Patients report substantial pain, stiffness, and declining physical function; those whose disease is not amenable to surgery require systemic therapy. Vimseltinib is an oral, switch‐control kinase inhibitor of the CSF1 receptor (CSF1R). Here, the authors report safety and efficacy of vimseltinib in patients with TGCT based on prior treatment. Cohort A in …

25.08.2026journal-article

Discover Oncology

Integrative machine learning identifies ECM1 as a candidate autophagy-related biomarker for immune infiltration and prognosis in hepatocellular carcinoma

Melika AmeliMojarad, Mandana AmeliMojarad, Seyed Mohammad Ayyoubzadeh

Abstract Background Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related mortality worldwide and exhibits substantial molecular heterogeneity, highlighting the need for reliable prognostic biomarkers and therapeutic targets. Increasing evidence suggests that autophagy plays a critical role in HCC progression. This study aimed to identify autophagy-related candidate biomarkers associated with prognosis and immune infiltration in HCC using an integrative machine learning and bioinformati …

25.08.2026journal-article

Statistics in Medicine

Nonparametric Assessment of the Calibration of Individualized Treatment Effects

Mohsen Sadatsafavi, Jeroen Hoogland, Thomas P. A. Debray, John Petkau

ABSTRACT An important aspect of the performance of algorithms that predict individualized treatment effects (ITEs) is moderate calibration, that is, the average treatment effect among individuals with predicted treatment effect of z being equal to z. The assessment of moderate calibration is a challenging task on two fronts: counterfactual responses are unobserved, and quantifying the conditional response function for models that generate continuous predicted values requires regularization. Perhaps because of these …

25.08.2026journal-article

Journal of the American Psychiatric Nurses Association

Telemental Health Approaches for Rural Opioid Use Treatment: An Integrative Review

Jayme K. Weber, Roxanne K. Vandermause, Cynthia M. Schmidt

Background: Opioid use disorder (OUD) continues to disproportionately impact rural communities. Telemental health (TMH) offers a promising strategy to bridge this divide, especially in the context of expanding telehealth-delivered medication for OUD (tele-MOUD). Aim: The purpose of this review was to examine the current evidence on TMH approaches for treating OUD among rural adults. Methods: Databases including EMBASE, MEDLINE, CINAHL, PsycINFO, Scopus, the Cochrane Library, and ClinicalTrials.gov were searched in …

25.08.2026journal-article

International Journal of Chemical Reactor Engineering

Comparative investigation of electrocoagulation performance using zinc and aluminium electrodes for food azo dye water treatment

Marwa Bendaia, Amina Eulmi, Sabir Hazourli, Naoual Houaidji, Mouna Cherifi, Adel Aitbara

Abstract This study was performed to evaluate the efectiveness of electrocoagulation (EC) process with both zinc (Zn) and aluminum (Al) electrodes for the elimination of decolorization efficiency (DE) and chemical oxygen demand (COD) from Cochineal Red A (E124) azo dye removal. Each electrode had a total surface area of 40 cm 2 , with a submerged area of 30 cm 2 . At current density and reaction time of 30 mA/cm 2 and 90 min for Zn, and 40 mA/cm 2 and 60 min for Al with a reel pH solution 7.10, and an ambient tempe …

25.08.2026journal-article

neuropsychiatrie

Case report of S-ketamine as treatment option for suicidal ideation and treatment-resistant depression in adolescents with early-onset psychosis

Nicolas Schmelzle, Katrin Neubacher, Paul L. Plener, Christian Scharinger

Summary Background Depressive symptoms and suicidality are highly prevalent in adolescents with early-onset psychosis (EOP) and often remain refractory to standard treatment. While S‑ketamine is an established treatment for treatment-resistant depression in adults (TRD), its use in primary psychotic disorders remains scarce due to risk of exacerbation of psychotic symptoms. Case presentation We present the case of a 16-year-old male with schizophrenia (ICD-10: F20.9) and chronic suicidality. Despite achieving remis …

25.08.2026journal-article

Pediatric Blood & Cancer

Short Pancreas in Children With Fanconi Anemia: A Report of Three Cases

Çiğdem Öztunalı, Zeynep Canan Özdemir, Ahmet Cem Demirşah

ABSTRACT A short pancreas (SP), characterized by the absence of the pancreatic tail, is a rare anomaly resulting from abnormal development of the dorsal pancreas and has been documented to cause endocrine pancreatic insufficiency. Fanconi anemia (FA) is associated with multiple congenital malformations and abnormalities in glucose–insulin metabolism; however, dorsal pancreatic anomalies have not been recognized as part of its phenotype. We report three children with FA in whom computed tomography (CT) demonstrated …

25.08.2026journal-article

JCO Oncology Practice

Predictive Risk Model for Early Post-Treatment Acute Care Use in Adolescent and Young Adult Patients With Cancer

Ryanne C. Buckley, Jacob N. Stein, Alexis C. Wardell, Tzy-Mey Kuo, Christopher Baggett, Hazel B. Nichols, Erin E. Hahn, Karen J. Wernli, Lawrence H. Kushi, Theresa H.M. Keegan, Andrew B. Smitherman

PURPOSE Adolescent and young adult (AYA) patients with cancer (ages 15-39 years at diagnosis) continue to have health care needs after completing treatment. Risk models to predict acute care events (ACEs) in this population may lead to earlier identification of high-risk populations. This study aimed to develop and validate a clinical risk model to predict ACEs in AYA patients with cancer during the early post-treatment period. METHODS Using the University of North Carolina Lineberger Cancer Information and Populat …

25.08.2026journal-article

The American Surgeon™

Medicaid Expansion and Overall Mortality in Lung, Breast, and Colorectal Cancer: A Difference-in-Differences Study

Oluwasegun Akinyemi, Jermaine Barrington Heath, Oladayo Oyebanji, Mojisola Fasokun, Bolarinwa Akinwumi, Siobhan Nnorom, Fadeke Ogunyankin, Kakra Hughes, Edward Cornwell, Gal Levy

Background Medicaid expansion under the Affordable Care Act (ACA) was designed to improve access to care for low-income adults, but its impact on cancer survival may vary across diseases depending on differences in screening, stage at diagnosis, and treatment pathways. Methods We conducted a retrospective cohort study using the National Cancer Database to identify adults aged 40-64 years diagnosed with lung, breast, or colorectal cancer between 2007 and 2021. States were classified by Medicaid expansion status, and …

25.08.2026journal-article

Journal of Experimental & Clinical Cancer Research

Mapping the NFYA 3′UTR landscape identifies alternative polyadenylation as a targetable vulnerability in prostate cancer

Giulia Pagani, Chiara Casirati, Cecilia Pandini, Stefania Fornezza, Chiara Priami, Giulia Fois, Sara Bisi, Aleksei Mironov, Roberta Cacioppo, Nicola Manfrini, Mihaela Zavolan, Francesco Nicassio, Enrica Migliaccio, Paolo Gandellini

Abstract Background Alternative polyadenylation (APA) is increasingly recognized as a pervasive oncogenic mechanism that reshapes post-transcriptional gene regulation and promotes tumor aggressiveness. Whether APA contributes to the dysregulation of NFYA —encoding the regulatory subunit of the oncogenic transcription factor NF-Y—in prostate cancer (PCa) remains largely uncharacterized. Methods We interrogated bulk, single cell and 3’-end RNA-sequencing data from PCa cell lines and patient samples to re-annotate and …

25.08.2026journal-article

Frontiers in Immunology

Combined treatment of benznidazole with an electrolyzed oxidizing water against Trypanosoma cruzi on immunological and anatomopathological features in a murine model of Chagas disease

Olivia Rodríguez-Morales, Alberto Aranda-Fraustro, José Luis Rosales-Encina

Background The rising reports of drug resistance in Trypanosoma cruzi strains and the high toxicity of current treatments necessitate the exploration of therapeutic alternatives for Chagas disease (ChD). This study evaluated the efficacy of combining benznidazole (BZN) with electrolyzed oxidizing water (EOW) to assess its impact on clinical parameters, immune response, and tissue integrity. Methods Forty female BALB/c mice were infected intraperitoneally with 150 blood trypomastigotes of the T. cruzi H8 strain. Sub …

25.08.2026journal-article

Frontiers in Oncology

Isolated gastric Langerhans cell histiocytosis: a case report and literature review

Xiaohan Ning, Yuan Tao, Yulu Wang, Kang Wan, Ling Wang, Qi Sun, Shuhua Yi, Shuhui Deng

Langerhans cell histiocytosis (LCH) is a rare histiocytic disease that predominantly affects young children, with adult cases being exceedingly uncommon. The most frequently affected sites in LCH are bones, lungs, and the pituitary gland, in whom gastrointestinal involvement is scarce. Primary isolated gastric LCH is rarely seen and typically manifests as a polypoid lesion. This article presented a case of LCH in an adult patient, while endoscopic examination revealed an erosive lesion on the greater curvature of t …

25.08.2026journal-article

Journal of Clinical Technology and Theory

Fertility-sparing treatment for a giant borderline ovarian tumor in an adolescent: a case report

Keying Wang, Tong Wei, Mubiao Liu

Borderline Ovarian Tumors (BOTs) are common ovarian epithelial tumors with biological behavior between benign and malignant lesions. The annual incidence of BOTs is approximately 4.5 per 100,000 population, which increases with age, starting from the 15–19 age group and peaking at 55–59 years. However, BOTs occurring in adolescents accompanied by giant tumors have a relatively low incidence and are rarely reported in the literature. This article reports the clinical diagnosis and treatment process of a 14-year-old …

25.08.2026journal-article

Tumori Journal

Reducing the burden of active surveillance monitoring examinations in prostate cancer: Insights from real-world data to inform clinical practice

Cristina Marenghi, Fabio Badenchini, Barbara Avuzzi, Mario Achille Catanzaro, Alessandra Casale, Alessia Casbarra, Laura Cattaneo, Melanie Claps, Valentina Guadalupi, Alberto Macchi, Antonella Messina, Sebastiano Nazzani, Barbara Noris Chiorda, Giuseppe Procopio, Silvia Stagni, Antonio Tesone, Tullio Torelli, Elena Verzoni, Sergio Villa, Riccardo Valdagni, Tiziana Rancati, Nicola Nicolai

Background: Active surveillance (AS) is standard for early-stage prostate cancer, though intensive monitoring continues due to concerns about reclassification to Grade Group (GG) ⩾ 2. We hypothesized that simple and inexpensive clinical parameters could identify patients with indolent disease for whom less intensive monitoring is safe. Methods: We analyzed upgrading to ISUP Grade Group (GG) ⩾ 2 in a large cohort of low-risk prostate cancer (PCa) patients on AS. We used mixed-effects logistic regression to develop a …

25.08.2026journal-article

Molecular Biomedicine

Exceptional treatment responses and molecular markers among 103 colorectal cancer cell lines

Anita Sveen, Jakob M. Stenersen, Theophilus Quachie Asenso, Solveig K. Klokkerud, Christian Kranjec, Ina A. Eilertsen, Bjarne Johannessen, Edward Leithe, Kushtrim Kryeziu, Manuela Zucknick, Ragnhild A. Lothe

Abstract Patients with colorectal cancer have few molecularly guided treatment options. Cancers with exceptional treatment response are valuable models for discovery of molecular response mechanisms and might reveal new predictive biomarkers to guide treatment selection. However, the rarity of events is a clinical challenge. We performed integrated high-throughput drug sensitivity testing ( n = 620 drugs) and molecular analyses of 103 colorectal cancer cell lines to build an in vitro foundation for exceptional trea …

25.08.2026journal-article

Journal of Clinical Oncology

Salvage Hypofractionated Accelerated Versus Standard Radiotherapy for Biochemical Recurrence After Radical Prostatectomy: A Phase III Randomized Clinical Trial

Youngju Song, Won Park, Hongryull Pyo, Yeon Joo Kim, Hanjong Ahn, Hwa Jung Kim, Young Seok Kim

PURPOSE To compare hypofractionated radiotherapy (RT) with conventional RT for treating biochemical recurrence following radical prostatectomy. METHODS Between 2019 and 2021, 316 patients with intermediate- to high-risk prostate cancer were randomly assigned to receive salvage RT with either 65 Gy in 26 fractions (hypofractionated RT, HYPO) or 66 Gy in 33 fractions (conventional RT, CONV). RT was delivered to the prostate bed, with elective pelvic nodal irradiation performed at the discretion of radiation oncologis …

25.08.2026journal-article

Neuro-Oncology Practice

“We do it because it matters” - From Insight to Impact when involving Neuro-Oncology Caregivers in the Design of a Supportive Intervention

Sara Nordentoft, Annika von Heymann, Rikke Guldager, Tiit Mathiesen, Helle Pappot, Karin Piil

Abstract Background Persons with lived experiences are a valuable resource to ensure that support interventions are grounded in real-world needs and thereby become relevant, acceptable, and impactful. The aim of this study is two folded: 1) to design a supportive group-based intervention for caregivers of patients diagnosed with glioblastoma with user involvement, 2) to evaluate the user involvement process. Methods An intervention development study using Patient and Public Involvement (PPI) engaged caregivers in t …

25.08.2026journal-article

Addiction Science & Clinical Practice

A novel harm reduction approach for oncology outpatients who smoke and refuse traditional tobacco treatment: a protocol for a type 1 hybrid effectiveness-implementation trial

Tracy T. Smith, Paris Bedford, Matthew J. Carpenter, Naomi Brownstein, Shikhar Mehrotra, Benjamin A. Toll, Alana M. Rojewski

Abstract Background Smoking rates are high among patients in cancer care, and improving quit rates among these patients is critical for improving survival outcomes. Yet, many oncology outpatients do not receive tobacco treatment, and a sizeable portion even refuse available evidence-based resources. E-cigarettes deliver lower levels of known carcinogens compared to cigarettes, and several rigorous trials have shown higher quit rates among people who receive e-cigarettes compared to those who receive nicotine replac …

25.08.2026journal-article

American Journal of Surgical Pathology

The Tumor Microenvironment Score and Its Subsite-Specific Relevance in Colon Cancer

Mari J. Jawad, Vilja V. Tapiainen, Ville K. Äijälä, Päivi H. Sirniö, Anne E. Tuomisto, Hanna Elomaa, Maarit Ahtiainen, Olli Helminen, Erkki-Ville Wirta, Toni T. Seppälä, Jan Böhm, Jukka-Pekka Mecklin, Henna Karjalainen, Meeri Kastinen, Timo Väisänen, Vesa-Matti J. Pohjanen, Markus J. Mäkinen, Jukka M. Rintala, Heikki Huhta, Juha P. Väyrynen

Colon cancer is a major global malignancy with significant mortality. Right-sided (RCC) and left-sided colon cancers (LCC) exhibit distinct clinicopathological characteristics. Tumor microenvironment score (TMS) combines Klintrup-Mäkinen grade, tumor stroma percentage, and tumor budding, classifying cases into 4 groups (TMS 0-3). Evaluation of TMS is an integrative method for prognostic classification; however, further validation is needed, and differences between RCC and LCC remain unclear. A discovery cohort (n=9 …

25.08.2026journal-article

European Journal of Haematology

A Phase IIa , Double Blind, Randomized, Placebo Controlled, Parallel, Multicentre, Proof‐of‐Concept Study to Evaluate the Efficacy and Safety of Desidustat Oral Tablet for Treatment of Sickle Cell Disease

Mohit Desai, Bhargav Solanki, Manish Hathila, Vikas Asati, Suchi Shah, Deven Parmar, Sanjay Vekariya, Kevinkumar Kansagra, Mayank Gangwar, Gunjan Kumar, Sudipto Roy, Aparna Mukherjee

ABSTRACT Introduction Sickle cell disease (SCD) is an inherited hemoglobin disorder caused by a point mutation in the β ‐globin gene, producing hemoglobin S (HbS). Under hypoxic conditions, HbS polymerizes, leading to rigid, sickled erythrocytes with reduced deformability and increased endothelial adhesion, resulting in vaso‐occlusion and impaired tissue perfusion. Desidustat, a hypoxia‐inducible factor prolyl hydroxylase inhibitor, stabilizes HIF and enhances endogenous erythropoietin production. This Phase IIa st …

25.08.2026journal-article

Frontiers in Endocrinology

Early prediction of metastatic insulinoma using tumor size and biochemical markers: a retrospective cohort study

Annie Mathew, Ben Freudenberg, Marc Wichert, Frank Weber, Benedikt M. Schaarschmidt, Johanna Braegelmann, David Kersting, Dagmar Fuhrer, Harald Lahner

Introduction Insulinomas are rare functional pancreatic neuroendocrine tumors. Metastasis is found in up to 15% of patients and is difficult to predict at diagnosis. Methods We retrospectively analyzed 64 patients (56.2% female, median age 49 years) with biochemically confirmed insulinoma treated at a European Neuroendocrine Tumor Society Center of Excellence between 2010 and 2024, assessing clinical characteristics, tumor biology, diagnostics, treatments and survival (median follow-up 23 months) . Results Metastas …

25.08.2026journal-article

European Journal of Heart Failure

Heart Failure and Cancer: Incidence and Mortality Patterns, A Systematic Review and Meta-analysis

Luigi Sanasi, Antonio Iaconelli, Danila Azzolina, Pasquale Dolce, Christian Cardile, Lorenzo Cacioli, Alessandro Forni, Matteo Busti, Luca Sensini, Nicola Riccardo Pugliese, Domenico D’Amario, Giovanni Pecorini, Mattia Galli, Giovanna Liuzzo, Francesco Burzotta, Riccardo Rinaldi, Moustafa I Morsy, Pasquale Maffia, Pierpaolo Pellicori, Jocelyn M Friday, Mark Petrie, Bernhard Haring, Michael Böhm, Markus S Anker, Javed Butler, Filippo Crea, John G F Cleland

Abstract Background Cancer and heart failure (HF) frequently coexist due to population ageing and improved survival for both conditions. HF is a well-recognised complication of oncologic therapies and a potential association between HF and subsequent cancer incidence has been recently noticed. We therefore conducted a meta-analysis to quantify cancer incidence and mortality in patients with and without HF. Methods Databases were searched from inception to 15 February 2026. Data from observational studies and random …