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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

Open Research Europe

Process measures developed for the routine monitoring of low-value care with electronic health data: A scoping review

Luc Saulnier, Daniele Franzoi, Anne Gulbech Ording, Jan Mainz, Søren Paaske Johnsen, Kathrine Hald

Background Low-value care (LVC) are medical services where the potential harms or costs outweigh expected clinical benefits. Despite growing adherence to initiatives such as Choosing Wisely, approaches to routinely monitor and reduce LVC across healthcare systems remain limited. Process measures are particularly relevant for this goal, as they capture actions taken during care delivery and can inform de-implementation strategies. Objective To map the extent and nature of evidence on process measures developed to ro …

29.08.2026journal-article

Mini-Reviews in Medicinal Chemistry

Mitochondrial Dynamics and Bioenergetic Reprogramming: Drivers of Cancer Therapy Resistance

Varsha Johariya, Vaibhav Singh, Rakesh Kore, Santosh Kumar, Ravichandran Veerasamy, Amit K. Tiwari, Harish Rajak

Abstract: Mitochondria, often referred to as the powerhouses of the cell, play a pivotal role in maintaining cellular homeostasis through the regulation of energy production, redox balance, and apoptosis. Recent evidence highlights the significance of mitochondrial dynamics, fusion, fission, biogenesis, and mitophagy, enabling cells to adapt to changing physiological and environmental conditions. Dysregulation of these dynamic processes alters mitochondrial function, promoting metabolic reprogramming, evasion of ap …

29.08.2026journal-article

Scientific Data

Digital Public Mental Health: a dataset for monitoring mental health in Brazil

Gabriel Souto, Marcel Pedroso, Raquel de Souza Martins, Rebecca Salles, Matheus Miloski, Carmen Corrêa Bonifácio, Ariane Camilo Pinheiro Alves, Carlos Leonardo Souza Cardoso, Carolina C. Carvalho, Ricardo A. D. Oliveira, Flavio Kapczinski, Ives C. Passos, Jefferson da Costa Lima, Raquel B. De Boni

Abstract The scarcity of primary data and challenges in analyzing secondary data hinder comprehensive mental health monitoring and the development of evidence-based policies. In Brazil, although multiple health information systems capture critical mental health data, these systems lack integration, robust analysis, and systematic presentation of mental health indicators. This study introduces the Digital Public Mental Health Dataset, a comprehensive, transparent, and reproducible data resource that consolidates dat …

29.08.2026journal-article

Discover Artificial Intelligence

Public-sector digital transformation in the age of generative AI

Gideon Mekonnen Jonathan

Abstract Digital transformation (DT) remains central to information systems and public administration scholarship, particularly amid the rapid emergence of generative artificial intelligence (GenAI). This study presents a systematic literature review of 125 peer-reviewed articles published between 2021 and 2026 to synthesise contemporary public-sector DT dynamics. Following the PRISMA 2020 reporting standard and thematic synthesis, the review maps conceptualisations of DT, identifies key organisational, technologic …

29.08.2026journal-article

Communications Medicine

Benchmarking large language models for HIV medical decision support

Gonzalo Cardenal-Antolin, Jacques Fellay, Bashkim Jaha, Huldrych F. Günthard, Johannes Nemeth, Roger Kouyos, Niko Beerenwinkel, Diane Duroux

Abstract Background Large language models (LLMs) are emerging as tools to support clinical decision making. HIV management is a compelling use case due to its complexity and dynamic nature, involving diverse treatment options, comorbidities, and adherence challenges. However, integrating LLMs into clinical practice raises concerns about accuracy, safety, and clinician acceptance. Despite growing interest, their performance in HIV care remains poorly studied, and benchmarking is lacking. Methods We developed HIVMedQ …

29.08.2026journal-article

Nursing Open

Risk Factors for Postpartum Weight Retention in Postpartum Women: An Integrative Review

Shanxia Chen, Meiyu Wang, Yue Wei, Zhuangwei Li, Xiaodan Wang, Hui Song

ABSTRACT Aims To summarise and synthesise extant research studies that identify risk factors for the development of postpartum weight retention in postpartum women. Design Integrative review. Review Methods This review was guided by Whittemore and Knafl's methodology. Eleven databases were searched for relevant original studies from database creation to November 25, 2025. Two researchers independently screened articles against the predefined inclusion and exclusion criteria, extracted data, and assessed the quality …

29.08.2026journal-article

Translational Medicine

Elastic properties of neck vessels in six-year-old children born with extremely low, very low and low body weight

A. I. Mulyukova, L. V. Yakovleva, Z. K. Galysheva, G. N. Shangareeva

Background. The aim of the study was to investigate the elastic properties of the neck vessels in 6-year-old children born with extremely low (ELBW), very low (VLBW) and low body weight (LBW) as predictors of the development of cardiovascular diseases in subsequent years. Objective. To study the elastic properties of the neck vessels in 6-year-old children born with ELBW, VLBW, and LBW as predictors of the development of cardiovascular diseases in subsequent years. Materials and methods. The elastic properties of t …

29.08.2026journal-article

International Journal of Research in Medical Sciences

Clinical characteristics and treatment outcomes of benign laryngeal lesions: a retrospective observational study from a tertiary care centre

Hiranya Prova Saikia, Nilmoni Nath, Maitrayee Deb, Debajyoti Das

Background: The larynx is a complex organ of the upper aerodigestive tract responsible for phonation, respiration, and airway protection. Benign laryngeal lesions commonly present with hoarseness of voice and significantly affect quality of life. Early diagnosis and appropriate management are essential to restore normal vocal function and prevent chronic morbidity. Methods: A retrospective observational study was conducted in the department of otorhinolaryngology, Assam Medical College and Hospital, Dibrugarh, from …

29.08.2026journal-article

EDULEC : Education, Language, and Culture Journal

English Language Needs for Workplace Communication in Makassar's Health and Tourism Sectors: An ESP Needs Analysis

Nadya Nurhidayah N

This study identifies English for Specific Purposes (ESP) needs related to workplace communication among health and tourism practitioners in Makassar, Indonesia. A sequential explanatory mixed-methods design was used to combine a quantitative needs survey with qualitative stakeholder interviews. The quantitative phase involved 100 purposively selected practitioners in international-facing health and tourism roles. A 25-item Likert-type questionnaire examined professional tasks, linguistic skills, and perceived comp …

29.08.2026journal-article

Advanced International Journal of Multidisciplinary Research

A Comparative Evaluation of Gross Non-Performing Assets of Listed Public Sector and Private Sector Banks in India: An Empirical Study

MEGHA G, BHARATH V

Non-Performing Assets (NPAs) are one of the major factors which ascertain the financial health and asset quality of banks. A high level of NPAs has a negative impact on profitability, liquidity, lending capability and financial stability. Over the past decade, significant reforms have taken place in the Indian banking sector, leading to enhanced credit monitoring, recovery procedures, and regulatory oversight. Nevertheless, there is continued variation in performance of Public Sector Banks (PSBs) and Private Sector …

29.08.2026journal-article

Clinical Child and Family Psychology Review

Kids These Days! A Cross-Temporal Meta-Analysis of Changes in Emotional and Behavioral Problems of Population-Based Samples Over the Past Decades

Boglarka Vekety, Zsofia K. Takacs, Tamas Kói, John Protzko, Heather C. Whalley, H. N. Alexander Logemann

Abstract There is a general belief that mental health problems are increasing in younger generations, though little objective comparisons exist. The current meta-analysis examines changes in subclinical mean-level overall symptom burden and shifts in specific domains among population-based samples of youth (1–18 years) globally over the last four decades. We search systematically in PubMed, Web of Science, Scopus, EBSCO and Google Scholar with pre-registered criteria. Included studies ( k = 175, N = 418,528) use th …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Determinants for antibiotic therapy less or more than 7 days in pediatric oncology patients with bacteremia: a global multicenter retrospective study

Griselda Escobedo-Melendez, Joseph Wardell, Parthasarathi Bhattacharyya, Joanna Acebo, Riyadi Adrizain, Bambang Ardianto, Martha Avilés, Maribel Baquera Arteaga, Shymaa Elsayed, Dolores Freire Jijon, Samanmalee Gunasekara, Asher Hancock, Hilda Hernandez, Kim Hoa, Reham Khedr, Yanina Lagala, Jacqueline Levy, Sergio Licona, Medalit Luna, Alejandra Nava, Genara Santana, Eneida Sánchez Medina, Meenakshi Devidas, César Villegas, Sheena Mukkada

Abstract Background Randomized trials support the non-inferiority of short-course (≤7 days) antibiotic therapy for bacteremia; however, these studies commonly exclude immunocompromised patients. Shorter regimens may reduce drug toxicity while optimizing resource utilization and patient quality of life. Evidence to guide treatment duration in immunocompromised children remains limited. Methods We conducted a global, multicenter retrospective study of bacteremia in children with cancer ≤18 years old treated between A …

29.08.2026journal-article

Egyptian Journal of Radiology and Nuclear Medicine

Value of computed tomography derived extra cellular volume fraction in prediction of the pathologic grade of rectal adenocarcinoma

Mary Roman Boles, Karim Atwa, Mohamed Elshal, Rasha Mostafa Mohamed Ali

Abstract Background Rectal cancer is one of the leading causes of cancer-related deaths worldwide. The degree of tumor differentiation is one of the most important factors on which the prognosis of rectal cancer. The pathological grading of rectal adenocarcinoma is the gold standard for diagnosis but it is an invasive procedure. Consequently, the aim of the current study was to assess the possibility of prediction of the pathologic grading of rectal adenocarcinoma, using non-invasive CT-derived extracellular volume …

29.08.2026journal-article

YANGI DAVR ILM-FANI: INSON UCHUN INNOVATSION G‘OYA VA YECHIMLAR

ЦИФРОВЫЕ ИНДИКАТОРЫ КОРРУПЦИОННЫХ РИСКОВ ПРИ ГОСУДАРСТВЕННЫХ ЗАКУПКАХ В СФЕРЕ АВТОМОБИЛЬНЫХ ДОРОГ

Комила Ахмедова

В данном тезисе исследуются возможности применения цифровых индикаторов для выявления коррупционных рисков в процессе государственных закупок, которые осуществляются в сфере автомобильных дорог Республики Узбекистан. Основное внимание сосредоточено на признаках, которые могут указывать на наличие аффилированности между участниками закупок, снижение уровня конкуренции, необоснованный рост стоимости работ, неоднократное изменение контрактных условий, а также расхождение между объёмом финансирования и фактическим выпо …

29.08.2026journal-article

International Journal of Environmental Research and Public Health

Prevalence of Hepatic and Splenic Melioidosis: A Systematic Review and Meta-Analysis

Jongkonnee Thanasai, Anchalee Chittamma, Supphachoke Khemla, Atthaphong Phongphithakchai, Moragot Chatatikun, Jitbanjong Tangpong, Sa-ngob Laklaeng, Jirart Songsri, Wiyada Kwanhian Klangbud

Background: Melioidosis is a potentially life-threatening infection caused by Burkholderia pseudomallei. Hepatic and splenic involvement are recognized manifestations of disseminated melioidosis; however, reported prevalence varies considerably across studies, and no quantitative synthesis has been available. This systematic review and meta-analysis aimed to estimate the pooled prevalence of hepatic, splenic, and concomitant hepatosplenic involvement in patients with melioidosis. Methods: A systematic search of Pub …

29.08.2026journal-article

Sensors

From Single-Modal to Multi-Modal Artificial Intelligence in Alzheimer’s Disease: A Systematic Review of Databases, Modalities, Diagnostic Performance, and Clinical Translation Challenges

José Menezes, Maria Inês Barbosa, Pedro Miguel Rodrigues

Alzheimer’s disease (AD) is the leading cause of dementia and a major cause of death worldwide, making early detection a critical clinical priority. Because pathological changes may begin 15–20 years before symptom onset, artificial intelligence (AI) has emerged as a promising tool for identifying and characterizing AD. In particular, multi-modal approaches that integrate cognitive, biological, and sensor-based data have attracted growing interest. This systematic review compares single- and multi-modal AI strategi …

29.08.2026journal-article

BMC Medical Informatics and Decision Making

Real-world implementation and evaluation of a pharmacogenomic clinical decision support system for allopurinol and HLA-B*58:01

Kuan-Hsuan Chen, Shi-Yun Goh, Chia-Lin Chou, Han-Yi Tsai, Chih-Fang Liu, Chung-Ping Lu, Chin-Chin Ho, Chian-Ying Chou

Abstract Background Allopurinol-induced severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), are strongly associated with the HLA-B*58:01 allele. Despite guidelines recommending genotyping prior to initiation, clinical implementation remains suboptimal. This study evaluated the real-world effectiveness of an electronic health record (EHR)-integrated clinical decision support system (CDSS) designed to enforce point-of-care HLA-B*58:01 testing. Met …

29.08.2026journal-article

Medical Oncology

Risk-adapted first-line therapy selection in advanced EGFR-mutant NSCLC: a practical clinical algorithm integrating tumor biology and patient factors

Ashish Sharma, Joecelyn Kirani Tan, Harendra Kumar, Hareesha Rishab Bharadwaj

Abstract Advanced EGFR -mutant non-small cell lung cancer (NSCLC), specifically tumors harboring classical activating mutations (exon 19 deletions and L858R substitutions, which are the exclusive focus of this review), is no longer a single-treatment landscape. The MARIPOSA and FLAURA2 phase 3 trials have established that combination regimens of amivantamab plus lazertinib and osimertinib plus platinum-pemetrexed, respectively, extend both progression-free and overall survival compared with osimertinib monotherapy. …

29.08.2026journal-article

Journal of Sleep Research

Lack of Efficacy of Low‐Dose Cyclobenzaprine on Electromyographic Activity Related to Sleep Bruxism: A Randomized Crossover Double‐Blind Placebo‐Controlled Clinical Trial

Matheus Herreira‐Ferreira, Cibele Dal Fabbro, Gilles J. Lavigne, Juliana Stuginski‐Barbosa, Peter Svensson, Paulo César Rodrigues Conti, Leonardo Rigoldi Bonjardim

ABSTRACT Sleep bruxism (SB) is a motor activity characterized by repetitive masticatory muscle contractions during sleep, commonly associated with tooth damage and jaw pain or headache. Pharmacological management strategies targeting its central nervous system‐related mechanisms remain limited. This study aimed to evaluate whether a low dose of a central muscle relaxant, cyclobenzaprine, reduces SB‐related muscle activity, maximum voluntary bite force and self‐reported bruxism awareness. A randomized, double‐blind, …

29.08.2026journal-article

Asian Journal of Medicine and Health

Instrument-Assisted Soft Tissue Mobilisation and Cryokinetics in Frozen Shoulder: A Critical Narrative Review of Comparative Effectiveness, Mechanistic Plausibility and Evidential Gaps

Nishi Lodha, Shilpa Ameta

Frozen shoulder is a painful and mobility-limiting condition of the glenohumeral joint whose fibrotic, inflammatory and neuro-immune substrate has been characterised in increasing detail over the past decade. Rehabilitation practice has nevertheless diversified faster than the supporting evidence, and two mechanically dissimilar adjuncts have entered routine use: instrument-assisted soft tissue mobilisation, in which rigid ergonomic tools deliver controlled shear and compressive loads to periarticular soft tissue, …

29.08.2026journal-article

Erciyes Üniversitesi Veteriner Fakültesi Dergisi

Detection of Salmonella Typhimurium in the Milk of a Cow with Mastitis: A Red Alert for Reproductive Health and Food Safety

Selda Beker, Serpil Kahya Demirbilek

This case report describes the microbiological isolation and characterisation of Salmonella enterica serovar Typhimurium (4,12:i:1,2) from the milk of a six-year-old Holstein cow with chronic mastitis and infertility. Milk and faecal samples collected during a farm investigation were subjected to bacteriological analysis in accordance with FDA and ISO standards, respectively. The isolate was identified using the BD PhoenixTM 100 automated system and subsequently serotyped at the Etlik Veterinary Control Central Res …

29.08.2026journal-article

Veterinary Medicine and Science

A Rare Case of Cutaneous Infection by Corynascus verrucosus in a Shih Tzu Dog: Molecular Identification and Phylogenetic Analysis

Mohammad Ghahremani, Aghil Sharifzadeh, Iradj Ashrafi Tamai, Ghazale Faridfar

ABSTRACT Background Fungal infections are important causes of dermatological disease in companion animals and may involve a diverse range of clinically relevant fungal pathogens. Accurate identification of the causative agent is essential for appropriate diagnosis, treatment and assessment of potential zoonotic risks. Objectives This study aimed to characterize a fungal isolate from a canine cutaneous lesion in Tehran, Iran, using morphological, molecular and phylogenetic analyses. Methods Skin scrapings were asept …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Impact of Fidaxomicin De-Restriction on Clostridioides difficile Episodes in Hospitalized Pediatric Cellular Therapy Patients

Andrew Karnaze, Darra Drucker, Regina Orbach, Leila C Posch

Abstract Background Pediatric patients undergoing cellular therapy (CT) with hematopoietic cell transplantation (HCT) or chimeric antigen receptor T-cell (CAR-T) therapy are vulnerable to Clostridioides difficile infection (CDI). Recent guidelines recommend fidaxomicin treatment for first and recurrent uncomplicated CDI episodes in this population, though pediatric real-world data is limited. Fidaxomicin is narrower spectrum, dosed less frequently, and can be used for shorter durations versus enteral vancomycin. In …

29.08.2026journal-article

Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer)

Empowering Vulnerable Adolescents: The Role of Targeted Education and Primary Health Care in Addressing Smoking Risk among Orphaned Adolescents

Marshell Timotius Handoko

Background: Indonesia continues to face major challenges in tobacco control, with a high prevalence of smoking, including among adolescents. Orphaned adolescents constitute one of the most vulnerable populations, owing to minimal parental supervision and high exposure to psychosocial stress, both of which increase the risk of smoking behavior. This study aimed to evaluate the effectiveness of an educational intervention on the dangers of smoking for orphaned adolescents at the Maktabul Aitam Orphanage for Orphaned …