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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Archives of Pathology & Laboratory Medicine

False Results in Urine Drug Screen for Amphetamine, Methamphetamine, and Ecstasy: A Systematic Review

Zahra Babazadeh Igdir, Mohammad Delirrad, Adel Ghorani-Azam

Context.— Amphetamines and methamphetamines are used for their hallucinogenic and euphoric effects. Owing to structural similarity of the drugs and lack of specificity in antibody-based drug screening methods, these tests are associated with false results, which can lead to misinterpretation with catastrophic consequences. Objective.— To summarize all drugs and chemicals that can lead to false-positive and false-negative test results for amphetamine and methamphetamine. Data Sources.— A systematic literature search …

27.08.2026journal-article

British Journal of Dermatology

Can a Treatment-Responsive Molecular Clock Independently Timestamp Psoriatic Skin?

Danli Zhong

This Letter discusses a methodological concern in the transcriptomic analysis by Zhan et al., in which ZeitZeiger was used to infer sampling time in psoriatic skin datasets. Because several treatment-responsive clock genes may also contribute to molecular time prediction, additional diagnostics are needed to distinguish restoration of temporal immune organization from treatment-related predictor drift.

27.08.2026journal-article

Clinical Journal of Health Sciences

Compensatory Adaptation Theory: A Developmental Model of Psychological Disequilibrium to Adaptation, Maladaptation, and Adaptive-Appearing Maladaptation

Mehmet Çakıcı

Psychological imbalance and maladaptation are generally explained as the deterioration of an individual’s functioning in the face of stress, developmental vulnerability, or psychopathology. However, the individual is not merely a passive entity suffering from these processes, but is also part of an active system that strives to restore internal psychological balance. The Compensatory Adaptation Theory proposed in this article suggests that the subjective experience of psychological imbalance can trigger an adaptive …

1 Zitationen
27.08.2026journal-article

Journal of Computing and Electronic Information Management

Design of an Edge Computing System for Wind Turbine Condition Monitoring and Diagnosis of Variable-Speed Operating Conditions

Kunyu Xie, Hongda Yan, GuiLu Jiang, Jiahao Zhang, Xianhui Fu, Fujie Xu

As wind turbines continue to grow in size and power density, issues such as drive system misalignment and the reliability of critical components have become increasingly prominent, posing major risks to the safe operation of wind farms. Traditional condition monitoring systems face bottlenecks such as closed data structures, fixed algorithms, poor monitoring timeliness, and difficulties in feature extraction under non-steady-state conditions. This paper designs and implements a browser-server (B/S) architecture-bas …

27.08.2026journal-article

Frontiers in Dental Medicine

Rare mandibular metastasis of neuroblastoma in a child: a case report

Safaa El Omari, Malika Afif, Sana Bensouda, Samira El Arabi

Although neuroblastoma is a common malignant tumor in children and distant metastases are frequently observed, involvement of the mandible remains rare. We report the case of a 7-year-old boy presenting with a right mandibular mass associated with an oral lesion in the region of tooth 46, suggestive of a secondary lesion. Histopathological examination of the biopsy specimen confirmed the diagnosis, whereas imaging initially suggested lymphoma, soft tissue sarcoma, or osteosarcoma. Staging work-up revealed an adrena …

27.08.2026journal-article

World Journal of Otorhinolaryngology - Head and Neck Surgery

Generative AI and Clinicians Show Comparable Prognostic Reasoning From Clinical Narratives in Biologic‐Treated CRSwNP

Sholem Hack, Chase Kahn, Ainhoa Garcia‐Lliberos, Cristina Rodriguez‐Prado, Ameen Biadsee, Maxime Fieux, Mark Liu, Eran Glikson, Masayoshi Takashima, Omar G. Ahmed, Raj Sindwani, Dennis M. Tang, Christopher R. Roxbury

ABSTRACT Objective To compare the ability of large language models (LLMs) and otolaryngologists to identify prognostic signals from brief clinical vignettes in CRSwNP. Methods In this blinded study, 68 adults initiating biologic therapy for CRSwNP (≥ 36 months follow‐up) were represented by standardized vignettes derived from documentation immediately before biologic initiation. Vignettes summarized symptoms, prior surgery, comorbidities, and medications. Biomarkers, imaging scores, smell testing, and follow‐up dat …

27.08.2026journal-article

Chronic Diseases and Translational Medicine

Efficacy and Safety of Durvalumab and Tremelimumab in Metastatic Non‐Small Cell Lung Cancer: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Ikhwan Rinaldi, Eric Ricardo Yonatan, Tasia Esterita

ABSTRACT Purpose Immune checkpoint inhibitors have transformed treatment strategies for metastatic non‐small cell lung cancer (mNSCLC). This study aimed to assess the efficacy and safety of durvalumab combined with tremelimumab compared with those of standard chemotherapy, particularly in patients with low or negative PD‐L1 expression, and in the overall population. Methods A systematic review and meta‐analysis of randomized controlled trials (RCTs) was conducted following PRISMA 2020 guidelines. Pooled efficacy an …

27.08.2026journal-article

Arthroscopy

Editorial Commentary : Hip Microinstability: From Diagnostic Chaos to Clinical Precision

Vikas Khanduja

Abstract Hip microinstability is now widely accepted as a distinct clinical entity, yet consensus on how to diagnose it remains elusive. A current systematic review found 23 studies proposing 32 distinct diagnostic criteria across clinical history, physical examination, imaging, and intraoperative findings, evidence of a field still searching for a unified standard. Intraoperative ease of distraction, the most cited criterion, lacks reproducibility across surgeons and centers, whereas the hyperextension‐external ro …

27.08.2026journal-article

Frontiers in Medicine

Rapid scale-up of hospital-at-home services during wartime: lessons learned from the Sheba Medical Center experience

Anat Ekka Zohar, Boris Fizdel, Liat Aroshass, Liron Vaserman, Galia Barkai, Shani Edelman, Rachel Sarafraz, Eyal Leshem, Matan Peri, Asaf Biber, Yael Frenkel Nir, Gad Segal

Background Sheba BEYOND, the telemedicine-governed hospital within the Sheba medical center includes a unique telemedicine-based service for internal-medicine patients suffering from acute illness since 2020, serving as a viable alternative to in-hospital stay. During March 2026, amid an Israeli war on two fronts, Iran and Lebanon, the urgent need to transfer over 1,900 (in-hospital) patients to underground facilities under continuous missile attacks necessitated immediate, massive fortification of our HaH services …

27.08.2026journal-article

Frontiers in Nutrition

Diagnostic variability in sarcopenia and sarcopenic obesity among older adults: a clinical and public health challenge

Táscya Morganna de Morais Santos, Gabriel Soares Bádue, Nykholle Bezerra Almeida, Celina de Azevedo Dias, Jessiane Rejane Lima Santos, Piettra Moura Galvão Pereira, Enaiane Cristina Menezes, Fabiana Andréa Moura, João Araújo Barros-Neto

Introduction Sarcopenia and sarcopenic obesity (SO) are highly prevalent among older adults; however, the lack of standardized diagnostic criteria compromises epidemiological comparability and clinical practice. Therefore, this study aimed to evaluate differences in the prevalence and diagnostic agreement of sarcopenia and SO according to different indicators of muscle strength and adiposity. Methods A cross-sectional study was conducted among 870 community-dwelling older adults. The prevalence and diagnostic agree …

27.08.2026journal-article

Journal of Marine Science and Engineering

Fault Diagnosis Method for Marine Rotating Machinery Based on Particle Swarm Optimization-Driven Kernelized Cascade Forest

Qingming Tan, Duankai Li, Jiawei Jiang, Kunxiang Ge

To address the problem of the fault mode discrimination accuracy of marine rotating machinery under the conditions of noise interference and limited training samples, a fault diagnosis method based on a particle swarm optimization-driven kernelized cascade forest is proposed. This method introduces RBF kernel mapping in the hierarchical structure of the cascade forest and uses PSO to conduct global optimization of the key parameters of the kernel function. Based on the marine fan test platform driven by a three-pha …

27.08.2026journal-article

International Journal of Engineering Research and Science & Technology

Explainable and Efficient AI-Based System for Automated Breast Cancer Diagnosis Using EfficientNet-B3, CBAM, and Grad-CAM

Velpula Siva Parvathi

Breast cancer is one of the leading causes of cancerrelated deaths among women worldwide, making early and accurate diagnosis essential for improving patient survival and treatment outcomes. Traditional histopathological examination is considered the gold standard for breast cancer diagnosis; however, manual analysis is time-consuming, labor-intensive, and subject to inter-observer variability. To address these challenges, this paper presents an Explainable and Efficient AI-Based System for Automated Breast Cancer …

27.08.2026journal-article

Journal of Clinical Medicine

An Unexpected Cause of De Novo Urge Incontinence Following Artificial Urinary Sphincter Placement: A Case Report

Ante Jakšić, Iva Žuža, Ivan Marin Sušanj, Ivan Vukelić, Josip Španjol, Dean Markić, Argimiro Collado Serra, Antun Gršković

Background: Stress urinary incontinence is one of the most common and debilitating complications following radical prostatectomy. Artificial urinary sphincter (AUS) implantation is the gold standard treatment for moderate to severe post-prostatectomy incontinence. Common complications include device infection, mechanical failure, component migration, urethral erosion, and urethral atrophy, which often require device removal and subsequent reimplantation. To our knowledge, erosion or migration of orthopedic osteosyn …

27.08.2026journal-article

Clinical Journal of Health Sciences

Treatment of Borderline Personality Disorder in Cognitive Behavioral Therapy: A Case Report

Berk İşlek, Meryem Karaaziz

Borderline Personality Disorder (BPD) is a personality structure characterized by significant instability in affect regulation, interpersonal relationships, and self-concept, leading to substantial impairment in functioning. This case report presents the Cognitive Behavioral Therapy (CBT) process applied to a 26-year-old female client for whom a clinical diagnosis of BPD was considered. Clinical interviews conducted in accordance with DSM-5 diagnostic criteria, together with findings obtained from the Minnesota Mul …

27.08.2026journal-article

Saudi Journal of Otorhinolaryngology Head and Neck Surgery

Efficacy of Topical Analgesics Used Perioperatively for Pain Control After Tonsillectomy: A Systematic Review

Abdulrahman Osama Shareefi, Abdullah H. Kutbi, Yousef Bahaa Abaalkhail, Ali Mohammad Alshdokhi, Mohammed A. Algarni

Abstract Posttonsillectomy pain is most pronounced during the first few days postoperatively and may persist for up to 1 week. In children, analgesic strategies have to facilitate oral intake and hydration, while also minimizing the use of opioids. Despite the importance of pain management strategies, no study has evaluated the effectiveness of analgesics used after tonsillectomy or compared their effects across specific time periods. Therefore, this systematic review aimed to evaluate the effectiveness of topical …

27.08.2026journal-article

Open Forum Infectious Diseases

Recombinant Influenza Vaccine and Influenza Outbreaks in US Nursing Homes: Results from a Pragmatic Cluster-Randomized Clinical Trial

Kevin W McConeghy, H Edward Davidson, Lisa Han, David H Canaday, Yasin Abul, Kaleen Hayes, Stefan Gravenstein

Abstract Background Influenza outbreaks in U.S. nursing homes contribute substantially to morbidity, mortality, and operational strain. Recombinant influenza vaccine may reduce transmission in long-term care settings, but high-quality evidence to support this effect is limited. To compare the risk of influenza outbreaks (confirmed outbreak: 1+ laboratory-confirmed cases; suspected outbreak 2+ influenza-like illness cases) among nursing homes randomized to recombinant quadrivalent influenza vaccine (RIV4) versus sta …

27.08.2026journal-article

Clinical Genetics

Identification of Copy Number Variants as a Suspected Cause of Cerebral Small Vessel Disease

Solomon K. Guyler, Neven Maksemous, Rodney A. Lea, Robert A. Smith, Heidi G. Sutherland, Lyn R. Griffiths

ABSTRACT Cerebral small vessel disease (CSVD) describes a range of neurological diseases affecting the small arteries, veins, and capillaries which supply the white matter and deep grey matter structures of the brain. They are the most common form of cerebrovascular disease, accounting for almost half of vascular dementia cases and approximately 20% of stroke incidence globally. Genetic testing is a routine diagnostic tool for monogenic CSVDs; however, less than 20% of patients have a causal variant in a known gene …

27.08.2026journal-article

Journal of Clinical Medicine

Association Between Bladder Management Strategies and Symptomatic Urinary Tract Infections in Patients with Chronic Spinal Cord Injury: Lessons from a 5-Year Longitudinal Cohort

Yu-Hui Huang, Chieh-Jui Chen, Yun-Sheng Chen, Kai-Siang Chen, Sung-Lang Chen

Background: Urinary tract infections (UTIs) are a leading cause of morbidity in patients with chronic spinal cord injury (SCI). This study examined the incidence of first and recurrent symptomatic UTIs in patients with chronic SCI and explored clinical factors associated with infection risk, with particular attention to bladder management methods and structural urinary tract abnormalities. Methods: We conducted a longitudinal observational study including 297 patients with chronic SCI (≥5 years post-injury; 215 mal …

27.08.2026journal-article

Bioengineering

Next-Generation Cartilage Repair: Clinical Use of Wharton’s Jelly MSCs and the Emerging Role of AI-Assisted Bioprinting

Bogusław Sadlik, Magdalena Matuszewska, Wojciech Klon, Ewa Stodolak-Zych, Kamila Rawojć

The treatment of articular cartilage defects remains a significant clinical challenge due to the tissue’s limited intrinsic repair capacity. This paper presents a review of clinical experiences with the use of Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) as a novel therapeutic option for cartilage regeneration. WJ-MSCs offer key advantages, including high proliferative potential, strong immunomodulatory properties, and low immunogenicity, making them suitable for allogeneic applications. This review des …

27.08.2026journal-article

Pediatric and Developmental Pathology

Spatial Lineage Divergence at Diagnosis in a Pediatric KMT2A -Rearranged Leukemia Presenting with Concurrent AML and B-LBL

Huan Zhang, Qiuling Miao, Yue Wang, Li Li, Meng Yi, Xianping Jiang

We describe a 1-year-2-month-old boy with KMT2A -rearranged leukemia presenting with concurrent acute myeloid leukemia in bone marrow and B-lymphoblastic leukemia/lymphoma in a right calf mass. Both lesions harbored an identical KMT2A::MLLT10 fusion, confirming common clonal origin. This represents the first documented case of spontaneous “spatial lineage divergence” at diagnosis, distinct from therapy-induced lineage switch. The finding highlights the potential need for multi-site biopsy and molecular profiling in …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Mechanisms and treatment of metabolic dysfunction-associated fatty liver disease after liver transplantation

Jun-Rong Liu, Liu Zhao, Qing-Hui Niu, Jin-Zhen Cai, Han-Yun Liu

Metabolism dysfunction-associated fatty liver disease (MAFLD) has emerged as a frequent complication for liver transplant (LT) recipients. In view of the high incidence of MAFLD after LT, research on MAFLD is of considerable clinical significance. Key research areas include the mechanisms responsible for the development of MAFLD following LT, therapeutic strategies, and the optimization of immunosuppressive regimens to achieve a balance between graft protection and metabolic protection. Most existing studies relati …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Pelvic floor rehabilitation improves anorectal function after sphincter-preserving surgery for low rectal cancer

Xiao-Jun Liu, Ming-Li Wei, Li-Li Liu, Jing-Jing Qin

BACKGROUND Sphincter-preserving surgery with prophylactic colostomy is the benchmark treatment for low rectal cancer, although postoperative anorectal dysfunction significantly reduces quality of life. Although pelvic floor muscle training seems effective in functional recovery, there is currently little systematic evidence regarding the efficacy of this therapy in this specific population. AIM To investigate whether structured pelvic floor muscle rehabilitation training provides better anorectal functioning than s …

27.08.2026journal-article

Journal of Law, Medicine & Ethics

Planetary Health: A Framework for Expanding the Boundaries of Global Health Law

Marlies Hesselman, Benjamin Mason Meier, Judith Bueno De Mesquita, Luciano Bottini Filho, Tsung-Ling Lee, Kriti Sharma, Sam Halabi, Monique van Cauwenberghe, Dominique Mollet, Gian Luca Burci

Abstract This article examines how the emerging framework of “Planetary Health” challenges us to reconsider the role and boundaries of global health law, for example by engaging with systems thinking, eco-centric perspectives, Indigenous knowledge, and newly emerging human rights. How does planetary health inspire novel thinking or new approaches around the conceptualization, design, implementation and/or interpretation of global health law and health-related rights, aiming to protect vital ecological foundations o …

27.08.2026journal-article

Journal of Medical Toxicology

Kratom-Associated Pulmonary Toxicity: A Systematic Review of Case Reports and Forensic Series with a Proposed Clinical Phenotype Classification

Venkatkiran Kanchustambham, Swetha Saladi

Abstract Introduction Kratom use has increased, including concentrated 7-hydroxymitragynine products, but pulmonary toxicity has not been systematically synthesized. Methods We systematically reviewed human case reports, conference abstracts, and forensic/autopsy series describing pulmonary outcomes after kratom, mitragynine, or 7-hydroxymitragynine exposure (PROSPERO CRD420261427143). Five databases were searched through 24 June 2026. Two reviewers independently screened, extracted, and appraised reports; causalit …