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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

International Science Journal

Physiological Impact of Carbon Dioxide Pneumoperitoneum on Cardiovascular Function and Respiratory Mechanics in Advanced Laparoscopic Surgery

Daniel Fernando Camargo Medina, Gary Bastian Medina Jimenez, Ana Carla Naranjo González, Diego Clemente Moreno, María Fernanda Carbajal Hernández, Susana María López Rojas, Jeanina de los Angeles Montero Galban, Pablo Eduardo Navarro López, Vicente Treviño Caballero, Justin Santiago Palacios Moreira

Carbon dioxide pneumoperitoneum is an essential component of advanced laparoscopic surgery, but the increase in intra-abdominal pressure required to create the surgical workspace produces important hemodynamic and respiratory alterations. This study analyzed the principal physiological effects of pneumoperitoneum on cardiovascular performance and respiratory mechanics, considering the influence of insufflation pressure, patient positioning, obesity, duration of surgery, mechanical ventilation, and cardiopulmonary r …

29.08.2026journal-article

Journal of Clinical Medicine

Rectal Shaving in Colorectal Endometriosis Surgery—Definition, Evidence and Variability

Petya Tanovska, Jörg Keckstein, Mihai Constantin, Maya Sophie de Wilde, Petra Klein, Harald Krentel

Objectives: We aim to evaluate how rectal shaving is defined in the current literature, how consistently this definition is used, and what this means for the results and comparability of the respective research about surgery in deep rectal endometriosis. Methods: A literature search was performed in PubMed covering the period from 1990 to 2026, using multiple search terms combining “rectal shaving”, “shaving”, “conservative surgery” and “endometriosis”. Records were screened by title and abstract; methods sections …

29.08.2026journal-article

The Turkish Journal of Pediatrics

Frequency of gastroptosis and gastroparesis in children with treatment-resistant dyspepsia and duodenogastric reflux: a prospective study

Melike Arslan, Edibe Gözde Başaran, Coşkun Fırat Özkeçeci, Bekir Nihat Doğrul, Necati Balamtekin

Background. Studies on gastroptosis and gastroparesis in children are limited. This prospective study aimed to evaluate the frequency of gastroptosis and gastroparesis and their association with duodenogastric reflux (DGR) and treatment-resistant dyspeptic symptoms in children. Methods. The study evaluated pediatric patients aged 2-18 years with dyspepsia who underwent upper gastrointestinal endoscopy between March 2020 and June 2022. Fluoroscopy and gastric emptying scintigraphy were performed in 88 patients (50 w …

29.08.2026journal-article

BMC Medical Informatics and Decision Making

Safety of patient-facing AI-generated medical advice: a structured clinical evaluation using acute appendicitis scenarios

Ali Rıza Erdoğan, Fahri Martlı, Mehmet Fatih Ekici, Pınar Erdoğan

Abstract Background Patient-facing large language model–based chatbots are increasingly used to seek medical advice and support health-related decision-making. While these tools provide accessible health information, their safety in high-risk, time-sensitive clinical scenarios remains insufficiently understood. Acute appendicitis represents a clinically relevant exemplar in which inappropriate or delayed guidance may lead to serious patient harm. This study aimed to evaluate the safety of patient-facing AI-generate …

29.08.2026journal-article

Human Genetics

From targeted SCN1A analysis to whole exome sequencing: clinical utility and novel genetic findings in a Hungarian paediatric epilepsy cohort

Renata Szalai, Agnes Till, Krisztina Galimurka, Zsolt Banfai, Anna Zsigmond, Kinga Hadzsiev

Abstract Epilepsy represents a highly prevalent neurological disorder with a significant genetic component, particularly implicating ion channel genes, including SCN1A . In this study, 431 individuals with heterogeneous paediatric-onset epilepsy phenotypes were assessed at the Department of Medical Genetics, University of Pécs between 2018 and 2024. Genetic investigations employed Sanger sequencing, targeted epilepsy gene panels, whole exome sequencing, and multiplex ligation-dependent probe amplification for SCN1A …

29.08.2026journal-article

PKLI Journal of Health Sciences

From Concept to Practice, Establishing Clinical Trials Unit at PKLI&RC in a Resource-Limited Setting

Sadia Hassan

Clinical trials are widely considered as gold standard research studies for evidence-based decision making in healthcare practices. Clinical trials, however, are quite expensive, time consuming and involve a wide range of complex and closely monitored operations including regulatory approvals, initial screening, subject accrual, data collection interpretation and dissemination of results. Conducting clinical trials in low-middle income countries with resource limiting settings adds to this complexity.

29.08.2026journal-article

Journal of Clinical Psychology

Reliability and Validity of the Chinese Version of the Parental Acceptance Questionnaire (6‐PAQ) Among Parents of Children With or Without Hearing Loss

Sini LI, Jianhe LI, Yamin Li, Jiao Xie

ABSTRACT Background The parental acceptance questionnaire (6‐PAQ) is a user‐friendly and contextually sensitive scale of psychological flexibility. Objective This research aimed to translate the original English version of the 6‐PAQ into Chinese and to test its psychometric properties among Chinese parents of children with or without hearing loss (HL). Methods Two phases were conducted: (1) translation from English to Chinese (6‐PAQ‐C), followed by a semantic equivalence evaluation between two versions, a pre‐test …

29.08.2026journal-article

Journal of Clinical Psychology

Exploring Perceived Utility of Living vs. Dying in Relation to Suicidal Ideation Over Time

Keyne C. Law, Megan L. Rogers, Yu‐Chin Lin, Brian W. Bauer

ABSTRACT Introduction Using the concept of games against nature from decision theory, this study explored whether the perceived utility of living and the perceived utility of dying were related to an individual's desire to live, desire to die, and suicidal ideation. Methods One hundred thirty‐eight participants listed their perceived costs and benefits associated with living and dying and rated their importance. They also answered questions about their desire to live, desire to die, and suicidal ideation. We tested …

29.08.2026journal-article

Diagnostics

Nailfold Capillaroscopy Patterns Are Associated with Impairment of DLCO in Very Early Diagnosis of Systemic Sclerosis: Insights of a Pulmonary-Vascular Interplay

Eugenio Capparelli, Barbara Ruaro, Eleonora Zaccara, Marco Vicenzi, Greta Pellegrino, Daniela Bompane, Laura Castelnovo, Antonio Tamburello, Elisabetta Ricchiuti, Paolo Carlucci, Daniele Colombo, Giorgio Bonardi, Maria Sole Chimenti, Antonino Mazzone, Paola Maria Luigia Faggioli

Background/Objectives: Data regarding the association between diffusing lung capacity for carbon monoxide (DLCO) and nail-fold Videocapillaroscopy (NVC) patterns are sparse in Very Early Diagnosis of Systemic Sclerosis (SSc; VEDOSS). The aim of this study was to detect differences in VEDOSS patients exhibiting reduced versus normal values of DLCO/single-breath (SB)% predicted (with a cut-off of 80%). Methods: A cross-sectional study was conducted in 65 VEDOSS patients, enrolled due to their fulfillment of the 2021 …

29.08.2026journal-article

Mathematics

Can IL-10 Inhibitor Therapy Alongside MDT Enhance Leprosy Treatment? A Comprehensive Mathematical Study

Salil Ghosh, Huina Zhang, Satyajit Mukherjee, Xianbing Cao, Amit Kumar Roy, Priti Kumar Roy

Leprosy is characterized by complex biological and cellular interactions, driven primarily by the interplay between Th1 and Th2 cells. In this study, we develop a deterministic mathematical model to investigate the interactions among healthy and infected Schwann cells, M. leprae bacteria, and Th1–Th2 immune responses. The positivity and boundedness of the proposed five-dimensional system are established, and the disease persistence condition is characterized in terms of the basic reproduction number (R0). The exist …

29.08.2026journal-article

Clinical Kidney Journal

Intratubular light chain amyloidosis: a comprehensive analysis of disease spectrum and clinicopathological characteristics

Xiaoyu Wang, Yuxuan Yuan, Dan Zhou, Zhengyun Zhu, Yujie Wang, Feng Xu, Xiaodong Zhu, Mingchao Zhang, Fan Yang, Shaoshan Liang, Caihong Zeng

Abstract Background The disease spectrum of intratubular light chain amyloidosis (AL) remains unkown. Methods Patients with intratubular AL from a single center were retrospectively analyzed and stratified into 3 groups: Group 1, complicated by extra-tubular amyloidosis; Group 2, complicated by light chain cast nephropathy (LCCN); and Group 3, isolated intratubular AL. Clinical features, pathological findings, treatment regimens, and renal prognosis were compared across the groups. Results The cohort (126 patients) …

29.08.2026journal-article

Journal of Clinical Interventional Radiology ISVIR

Outcomes of Microwave Ablation in T1a Renal Cell Carcinomas: A Retrospective Analysis

Andrew Whittering, Anthony Franklin, Arani Halder

Abstract Microwave ablation (MWA) is a suitable nonsurgical alternative for management of T1a renal cell carcinomas (RCCs). Variation exists in reported guidelines regarding the use of MWA in RCCs measuring 30 to 40 mm in size. The purpose of this retrospective study was to evaluate the overall success of MWA in managing RCCs through oncological and technical outcomes to provide insight into the management of these tumor sizes. A retrospective study of MWA for T1a RCC was undertaken at a large tertiary center betwe …

29.08.2026journal-article

International Journal of Research in Medical Sciences

Severe multiorgan toxicity following low-dose copper sulfate poisoning in a patient with Psoriasis vulgaris on methotrexate: a case report

Prince Rueban Manivannan, Vishaalpalaniswamy Ramaswamy, Sakthikumar Soundarrajan

Acute copper sulfate poisoning usually causes severe toxicity only after large ingestions. We report a man in his early 50s with psoriasis vulgaris receiving methotrexate who developed severe intravascular hemolysis, methemoglobinemia, acute hepatotoxicity, and acute kidney injury after ingesting only 1 g of copper sulfate. Serial peripheral blood smears, biochemical parameters, and clinical progression confirmed delayed multi-organ toxicity. He recovered following aggressive supportive care, forced alkaline diures …

29.08.2026journal-article

International Journal of Legal Medicine

Fatal waterhouse–friderichsen syndrome at autopsy: a systematic review and forensic diagnostic framework

Jessika Camatti, Anna Laura Santunione, Rossana Cecchi, Erjon Radheshi, Edoardo Carretto, Maria Paola Bonasoni

Abstract Waterhouse–Friderichsen syndrome (WFS) represents a fulminant septic condition characterized by bilateral adrenal hemorrhage and rapid clinical deterioration. Although classically associated with meningococcal infection, fatal cases occur across multiple infectious etiologies and heterogeneous clinical contexts. In forensic practice, diagnosis frequently relies on post-mortem interpretation rather than clinical recognition, making consistent pathological assessment essential. A systematic review was conduc …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Sociodemographic and Clinical Factors Related to Admission to the Pediatric Intensive Care Unit in Patients Hospitalized with COVID-19: A Post-Pandemic Study

Rojas Hernández, Juan Pablo, Rengifo Mosquera, María Paula, Gil Artunduaga, Mónica Alexandra, Gómez Urrego, José Fernando

Abstract Background The impact of COVID-19 on children has varied over time. Although most cases are mild, some require hospitalization and admission to the Pediatric Intensive Care Unit (PICU). In the post-pandemic period, the clinical and sociodemographic profile of at-risk patients is unknown, hindering early identification and timely management. The objective was to determine sociodemographic, clinical, and comorbidity factors associated with PICU admission in hospitalized patients with COVID-19 during the post …

29.08.2026journal-article

Patient Safety in Surgery

Current cybersecurity threats to patient safety in the operating room: a review

Mohamed Mustaf Ahmed, Omar Kasimieh, Uthman Okikiola Adebayo, Zhinya Kawa Othman, Shuaibu Saidu Musa, Rahmatullah Nazari, Olalekan John Okesanya, Francesco Branda, Jerico Bautista Ogaya, Don Eliseo Lucero-Prisno III

Abstract Surgical, anesthetic, and intensive care practices now depend on a large ecosystem of wired and wireless devices, robotic consoles, imaging and laboratory systems, and cloud infrastructure: the Internet of Medical Things and the smart operating room, which extends care beyond the physical theatre to transcontinental telesurgery. Connectivity that is useful in routine care becomes a failure mode during a cyber incident because surgical pathways depend on uninterrupted access to scheduling, imaging, electron …

29.08.2026journal-article

Scientific Reports in Medicine

The Impact of Perception and Fear on the Adoption of Protective Measures Against COVID-19: A Mediation Analysis

Ali Kılınç, Alaettin Ünsal, Didem Arslantaş

Objective: COVID-19 has had physical, mental, and social impacts worldwide, yet uptake of protective behaviors varied. We aimed to assess how COVID-19 disease perception and fear relate to adoption of precautions among adults in Türkiye. Methods: After ethics approval, we conducted a cross-sectional online survey in Türkiye (March 1–April 1, 2021) using researcher networks for recruitment. Measures included the COVID-19 Disease Perception Scale (dangerousness and contagiousness) and the Fear of COVID-19 Scale. Adhe …

29.08.2026journal-article

Clinical and Experimental Nephrology

Inflammatory and traditional risk factors associated with the progression of chronic kidney disease in patients with rheumatoid arthritis

Masafumi Sugiyama, Sayo Morita, Takashi Tsuchimoto, Saki Tsuchimoto, Chise Minami, Koji Kinoshita, Shinya Rai

Abstract Background Chronic kidney disease (CKD) is a significant comorbidity in patients with rheumatoid arthritis (RA). The relative contributions of inflammatory and traditional renal risk factors to CKD progression remain unclear. Methodology We retrospectively analyzed 601 RA patients. Renal function and urinary abnormalities were assessed using creatinine-based estimated glomerular filtration rate (eGFR) and urinary albumin. We examined the factors associated with high or very high CKD risk in KDIGO heatmap a …

29.08.2026journal-article

International Journal of Research in Medical Sciences

Clinical readiness and generalizability of artificial intelligence in implant dentistry: a systematic review of diagnostic accuracy, treatment planning, prognosis and external validation

Rohit Raghavan, Shajahan P. A., Akash R.

Artificial intelligence (AI) is increasingly being incorporated into digital dentistry. In implant dentistry, machine-learning and deep-learning systems have been investigated for radiographic diagnosis, anatomical segmentation, treatment planning, prosthetically driven implant positioning, and prediction of implant-related outcomes. To systematically evaluate the clinical applications of AI in implant dentistry, with particular emphasis on diagnostic accuracy, treatment planning, prognosis, external validation, ge …

29.08.2026journal-article

Water

Regional Water Resource Carrying Capacity Assessment and Barrier Factor Diagnosis Based on Combined Weighted-TOPSIS Model

Yang Zhang, Fan Wu, Fulong Chen, Chaofei He, Shuanglin Shao, Aihua Long, Zhengliang Yin

Water resource carrying capacity (WRCC) assessment provides an important basis for regional socioeconomic development planning and water resource management. In this study, an 18-indicator WRCC evaluation system was constructed for the Eighth Division of the Xinjiang Production and Construction Corps based on the Supply–Water-use Efficiency–Demand Pressure–Economy and Society–Regulation (SWDER) framework. Indicator weights were determined using a combined method integrating the Criteria Importance Through Intercrit …

29.08.2026journal-article

Journal of Clinical Medicine

Reduced Total Subgingival Bacterial Load in Patients with Ischaemic Stroke: A Case–Control Study of the Subgingival Microbiome and Carotid Atherosclerosis

Anita Siewko, Szymon J. Jurga, Maksymilian Aleksander Brzezicki, Izabela Wojtasz, Anita Nowak, Filip Czop, Maja Jurga, Iwona Towpik, Lukasz Dzieciuchowicz, Jaroslaw Piskorski, Radoslaw Kazmierski

Background/Objectives: Periodontal infection has been associated with ischaemic stroke, usually as a matter of burden: more pathogens, more vascular risk. That framing derives from stroke-free populations and rests largely on surrogate endpoints, chiefly carotid intima-media thickness (IMT). Whether it holds once stroke has occurred is unclear. Methods: We concurrently recruited 50 patients with ischaemic stroke and 48 stroke-free controls in western Poland. The subgingival microbiome was quantified for nine period …

29.08.2026journal-article

Journal of Clinical Medicine

Effects of High-Intensity Interval Training in Older Adults: A Systematic Review of Randomized and Non-Randomized Intervention Studies

Paula Moreira, Sérgio Ferreira, Nuno Domingos Garrido, António M. Monteiro, Pedro Afonso, Alexandra Malheiro, Joana Ribeiro, Pedro Forte

Background: High-intensity interval training (HIIT) is a time-efficient exercise strategy, but its effects in older adults remain incompletely established. Objective: Our objective is to synthesize evidence on the effects of HIIT and aerobic interval training (AIT) on cardiorespiratory, metabolic, functional, cognitive, psychological, and quality-of-life outcomes in older adults. Methods: This systematic review was reported in accordance with PRISMA 2020. PubMed, Scopus, and Web of Science were searched through 13 …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Corynebacterium urealyticum Urinary Tract Infections in Pediatric Renal Transplant Recipients: Clinical Spectrum and Management Strategies

Guyu Li, Alicia Morales, Elizabeth Ristagno, Anna Huppler, Nipunie Rajapakse

Abstract Background Pediatric renal transplant recipients are at increased risk for Corynebacterium urealyticum urinary tract infections (UTIs), which can range from simple nephritis to encrusted pyelitis and infected nephrolithiasis. Limited data exist regarding clinical spectrum and standardized management strategies, contributing to variability in treatment and prognosis. We describe two pediatric renal transplant recipients with C. urealyticum-associated encrusted pyelitis and infected nephrolithiasis and outli …

29.08.2026journal-article

Journal of Nephrology

Burden of diagnosed and undetected hyperkalemia in Spain: Clinical characteristics, management, healthcare resource utilization, and costs

José Luis Gorriz, Roberto Alcázar, Patricia de Sequera, Enrique Morales, Miquel Blasco, Marco Montomoli, Alberto Ortiz

Abstract Background Management of hyperkalemia (HK) is challenging and suboptimal. This study analyzed the prevalence of HK and undetected HK, as well as management, clinical outcomes, healthcare resource utilization (HCRU), and costs. Methods Observational study comprising cross-sectional and retrospective analyses using secondary data from electronic health records (608,514 adults) from BIG-PAC database. The population comprised adults (n=7006) with a diagnostic code for HK, potassium >5.0 mmol/L and/or treatm …