Cancers
Exploring the Impact of T2-Weighted MRI Fat Saturation on Radiomics Stability for Brain Radionecrosis Prediction After Skull-Base Proton Therapy: A Pilot Study
Background/Objectives: In skull-base proton therapy, T2-weighted brain magnetic resonance (MR) imaging may be acquired with or without fat saturation (FS). The present study investigated the impact of this protocol variation on radiomics feature stability and brain radionecrosis (BRN) prediction. Methods: Paired T2-weighted FS and non-FS follow-up MR scans of proton-treated skull-base chordoma patients (n = 52) were used to assess feature stability. For BRN prediction (CTCAEv5 grade ≥ 1), baseline planning scans of …