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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

Asian Journal of Medicine and Health

Virtual Reality-Based Interventions for Upper Limb Rehabilitation in Parkinson’s Disease: A Scoping Review and Critical Evidence Synthesis

Krishnendu P. G., Riyas Basheer K. B., Ismail Hazim, Athul Krishna K. R., Subhashchandra Rai, Femina Hameed V. A., Nishka S. Bolar, Mohammed Sanabin

Upper-limb dysfunction in Parkinson’s disease compromises dexterity, movement scaling, coordination and the performance of everyday tasks, yet rehabilitation research has historically prioritised gait and balance. Virtual reality (VR) can deliver repetitive, task-specific practice with augmented feedback, adaptable challenge and game-based engagement, but the clinical value of VR specifically for arm and hand rehabilitation remains uncertain. This scoping review mapped and critically synthesised evidence on VR-base …

29.08.2026journal-article

Journal of Clinical Medicine

Dextrose Injections Across Temporomandibular Joint Mobility Disorders: A Scoping Review

Julia Kasprzycka, Maciej Chęciński, Justyna Wilk, Wojciech Macek, Maja Kosińska, Amelia Hoppe, Oliwia Jagiełło, Karolina Grzybowska-Kowalczyk, Tomasz Horodniczy, Zuzanna Baniak, Izabella Chyży, Kamila Chęcińska, Maciej Sikora

Background/Objectives: Temporomandibular joint (TMJ) mobility disorders encompass opposing clinical problems, ranging from hypermobility, subluxation, and recurrent dislocation to restricted mandibular mobility caused by disc displacement without reduction (DDwoR). Dextrose-based injections have been investigated in both settings, although their therapeutic objectives may differ. This scoping review mapped the clinical indications, injection protocols, outcomes, safety findings, and evidence gaps. Methods: PubMed/M …

29.08.2026journal-article

Journal of Complementary and Alternative Medical Research

Laboratory Biomarker Changes Following Extracorporeal Blood Oxygenation and Ozonation (EBOO): A Retrospective Eight-Patient Case Series

Abhinit Gupta

Background: Extracorporeal blood oxygenation and ozonation (EBOO) is an extracorporeal procedure involving oxygen-ozone exposure and blood filtration. Clinical evidence remains limited, and EBOO is investigational in many settings. Objective: To describe paired laboratory changes available before and after EBOO in eight adults treated during routine clinical care. Methods: This uncontrolled retrospective case series included eight heterogeneous patients with comparable pre- and post-procedure laboratory reports. Re …

29.08.2026journal-article

Communications Medicine

Pooled two-cohort MRI body composition phenotyping with open-source deep learning

Christian J. Mertens, Hartmut Häntze, Sebastian Ziegelmayer, Jakob Nikolas Kather, Daniel Truhn, Su Hwan Kim, Felix Busch, Dominik Weller, Benedikt Wiestler, Markus Graf, Fabian Bamberg, Christopher L. Schlett, Jakob B. Weiss, Steffen Ringhof, Elif Can, Jeanette Schulz-Menger, Thoralf Niendorf, Jacqueline Lammert, Isabel Molwitz, Avan Kader, Alessa Hering, Aymen Meddeb, Jawed Nawabi, Matthias B. Schulze, Thomas Keil, Stefan N. Willich, Lilian Krist, Martin Hadamitzky, Anke Hannemann, Florian Bassermann, Daniel Rueckert, Tobias Pischon, Alexander Hapfelmeier, Marcus R. Makowski, Keno K. Bressem, Lisa C. Adams

Abstract Background Body mass index fails to capture variation in fat and muscle distribution that determines metabolic health and disease risk. MRI enables radiation-free quantification of regional body composition, yet scalable open-source tools applied in pooled cohorts with differing acquisition protocols have been lacking. Methods MRSegmentator, an open-source nnU-Net-based pipeline, was applied to quantify visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (ASAT), gluteofemoral adipose tissu …

29.08.2026journal-article

Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer)

From Screen to Care: Physician Approaches to Overcoming Communication Challenges in Telemedicine

Imelda Ritunga, Mora Claramita, Sandra Widaty, Hardyanto Soebono

Background: The growth of telemedicine has encouraged physicians to adapt their communication techniques for remote consultations. Even though telemedicine enhances access and continuity of care, it also presents barriers to effective doctor–patient interaction. Aims: This study explores the communication challenges faced by physicians in telemedicine consultations and identifies the strategies they use to ensure effective and high-quality virtual care. Methods: A qualitative descriptive study was conducted through …

29.08.2026journal-article

Foot & Ankle International

Outcomes of Iliac Crest Bone-Block Arthrodesis After Failed First MTP Joint Surgery With Bone Loss

Nurettin Mantı, Melih Atalay, Nuri Koray Ülgen, Mehmet Orçun Akkurt, Sadık Emre Erginoğlu, Ali Öznur

Background: Failed first metatarsophalangeal (MTP) joint surgery with bone loss is a challenging revision problem. This study aimed to evaluate the radiographic and clinical outcomes of iliac crest bone-block arthrodesis in this setting. Methods: This retrospective cohort included 72 patients who underwent revision first MTP arthrodesis with tricortical iliac crest autograft between 2018 and 2022. All patients had at least 2 years of clinical and radiographic follow-up, and 83.3% had at least 3 years of follow-up. …

29.08.2026journal-article

International Journal of Research in Medical Sciences

Effectiveness of autologous leukocyte platelet-rich fibrin on orthodontic tooth movement: a split-mouth clinical study

Prahlad Jha, Vaibhav Misra, Rajeshwar Singh, Sonal Attri

Background: Prolonged orthodontic treatment is associated with increased risk of enamel demineralization, root resorption, periodontal complications and reduced patient compliance. Leukocyte platelet-rich fibrin (L-PRF), an autologous platelet concentrate rich in growth factors and cytokines, has been proposed as a biological adjunct to accelerate orthodontic tooth movement. To evaluate the effectiveness of L-PRF in enhancing orthodontic canine retraction. Methods: A split-mouth clinico-experimental study was condu …

29.08.2026journal-article

International Journal of Research in Medical Sciences

Jejunojejunal intussusception caused by a jejunal lipoma in a 92-year old patient: CT diagnosis

Samia Obilat, Yahya El Harras, Lina Lasri, Kaoutar Imrani, Ittimade Nassar

Adult intussusception is an uncommon cause of bowel obstruction and is usually associated with an identifiable pathological lead point. Among benign etiologies, submucosal lipomas of the small bowel are rare but may induce intussusception when they reach a significant size. We report the case of a 92-year-old man who presented with acute abdominal pain and subocclusive syndrome. Because of his history of bilateral inguinal hernias, strangulated hernia was initially suspected. Contrast-enhanced CT instead demonstrat …

29.08.2026journal-article

Diagnostics

AI-Assisted Multilabel Diagnosis of 12-Lead Electrocardiograms Using an Interpretable Stacked Deep Learning Model with External Validation

Asifa Tassaddiq, Aiman Albarakati, Rabab Alharbi, Carlo Cattani, Dalal Khalid Almutairi, Ruhaila Md Kasmani

Background: Automated interpretation of 12-lead electrocardiograms (ECGs) remains challenging because multiple abnormalities may coexist and appear in selected leads or brief waveform segments. We developed a compact and interpretable framework for five-superclass multi-label ECG diagnosis. Methods: We evaluated PTB-XL records using the official fold protocol, with folds 1–8 for training, fold 9 for validation monitoring and class-specific threshold selection, and fold 10 for independent internal testing. We then e …

29.08.2026journal-article

Polymers

Effects of Heat Treatment on the Mechanical Properties and Thermal Stability of Bamboo

Zilu Liang, Haiyun Jiang, Yimin Tan

Bamboo contains abundant hydrophilic components such as hemicellulose which result in poor interfacial compatibility with epoxy resin and, consequently, limit its application in bamboo–epoxy composite packaging materials. In this study, we subjected bamboo (aged 3–4 years) to vacuum heat treatment to investigate the effects of treatment temperature (140, 160, and 180 °C) and holding time (4 and 6 h) and systematically evaluated the resulting changes in density, surface color, microstructure, mechanical behavior, an …

29.08.2026journal-article

Translational Medicine

Dynamics of bioimpedance parameters during cardioversion in patients with atrial fibrillation

F. F. Bayramova, S. A. Zenin

Background. Heart rate conversion during cardioversion has a mixed effect on the functional response of the cardiovascular system. According to impedance cardiography data, one month after electrical cardioversion, the most significant changes were in cardiac index, cardiac power index, total peripheral resistance, and total peripheral resistance index, exceeding echocardiographic parameters in sensitivity. These data suggest that bioimpedance cardiography is a useful and timely method for dynamically monitoring he …

29.08.2026journal-article

BMC Medicine

Bladder cancer precision-cut tumor slices (PCTS) preserve functional immune microenvironment enabling ex vivo drug evaluation

Sarah Richtmann, Maja Radak, Viktor Sincic, Jenny Hugoson, Nadja Werner, Valeriia Skoryk, Darcy Wagner, Fredrik Liedberg, Kristina Lundberg

Abstract Background The development of effective cancer immunotherapies is hindered by the lack of preclinical models that faithfully preserve tumor-immune interactions. Current approaches provide limited representation of immune components, creating a critical translational gap between laboratory findings and clinical outcomes. Precision Cut Tumor Slices (PCTS) offer a promising solution by maintaining complete tumor architecture including native immune cell populations and spatial organization. Methods We establi …

29.08.2026journal-article

Current Tropical Medicine Reports

Rickettsial Diseases in the Mediterranean Basin: an Evolving Clinical and Epidemiological Challenge

Giulio D’Agati, Luca Pipitò, Chiara Iaria, Claudia Colomba, Antonio Cascio

Abstract Purpose of Review Rickettsial diseases represent a major cause of arthropod-borne febrile illness in the Mediterranean basin, where climatic conditions, vector ecology, and close human–animal interactions promote the circulation of a wide diversity of Rickettsia species. In recent years, advances in microbial genomics and molecular diagnostics have substantially refined rickettsial taxonomy, clarified phylogenetic relationships across the Spotted Fever, Typhus, and Transitional Groups, and enhanced recogni …

29.08.2026journal-article

Maltepe Tıp Dergisi

Long-Term Outcomes of Conservative Treatment in Traumatic Carotid Artery Dissection: A Case Report

Birol Özkal, Kadir Timuçin Turgutoğlu

Amaç: Travmatik karotis arter diseksiyonu (TCAD), künt servikal travma sonrası ortaya çıkabilen nadir ancak ciddi nörolojik sonuçlara yol açabilen bir vasküler yaralanmadır. Beş yılı aşan uzun dönem takip verilerinin sınırlı olması, doğal seyir ve konservatif tedavinin etkinliği hakkındaki bilgi eksikliğini sürdürmektedir. Bu çalışmanın amacı, konservatif tedavi altında altı yıl boyunca yaklaşık %90 düzeyinde stabil kalan sağ internal karotis arter TCAD olgusunu sunmak ve uzun dönem yönetim yaklaşımlarına katkıda b …

29.08.2026journal-article

The International Journal of Medical Robotics and Computer Assisted Surgery

Efficacy and Safety Analysis of Single‐Port Robotic Assisted Cholecystectomy Using a Novel Surgical Platform: A Bicentre, Single‐Arm, Prospective Phase II Clinical Study

Chao Jing, Kun Liu, Guowei Zhang, Hongwei Wu, Zhe Jia, Guoxin Li, Yaping Zhao, Zhongtao Zhang, Wei Guo

ABSTRACT Background Single‐port robotic cholecystectomy offers minimally invasive benefits. This trial evaluated the feasibility and safety of a novel system, MicroPort SA‐1000. Methods In this dual centre, single‐arm, prospective study, eligible patients underwent single‐port robot‐assisted cholecystectomy with MicroPort SA‐1000. The primary endpoint was the completion rate, while secondary endpoints included estimated blood loss, operating time, hospital length of stay and complications. Results From June 2023 to …

29.08.2026journal-article

Journal of Ayurvedic Herbal and Integrative Medicine

CARIES REMINERALIZATION THERAPY – AN IN VITRO EVALUATION OF THE EFFICACY OF THREE REMINERALIZING AGENTS BY SEM AND EDS ANALYSIS

Geeta IB, Pranjul Sharma, Rayala Lokesh, Urvashi Patel

Dental caries, by definition, is one of the most common diseases worldwide. It is dependent on biofilm, diet, and other factors. It causes mineral loss, disrupting the balance between demineralization and remineralization. This has led to the development of various treatment approaches for initial carious lesions. Remineralization requires a natural pathway to restore the mineral loss of hydroxyapatite (HAP) crystals. Many materials have been clinically evaluated and have demonstrated promising results.

29.08.2026journal-article

Healthcare

Artificial Intelligence in Prehospital Tele-Emergency Medicine: A Survey of Acceptance and Attitudes

Nadezhda Durdova, Mathias Schmidt, Hanna Schröder, Pia Thoma, Dominik Groß, Saskia Wilhelmy

Background/Objectives: Artificial intelligence (AI) is increasingly being used in medicine to improve the efficiency, accuracy, and timeliness of patient care. In prehospital tele-emergency medicine, AI also has the potential to address various challenges and support tele-emergency physicians. This study focuses on a specific AI-based decision support system being developed for use by practitioners. While technical feasibility is a prerequisite for the successful implementation of this system, social, ethical, and …

29.08.2026journal-article

The Nursing Scope

Occupational Stress and Nursing Performance in In-Patient Care: Organizational Determinants in a Nigerian Tertiary Hospital

Abiodun FATUKASI

Background: Occupational stress remains a major challenge in nursing practice, particularly in inpatient care settings characterized by demanding workloads, complex clinical responsibilities, and resource constraints. Persistent workplace stress can adversely affect nurses’ performance, clinical decision-making, communication, and patient safety. Despite growing concerns about occupational stress among nurses, evidence regarding its organizational determinants and impact on nursing performance in Nigerian tertiary …

29.08.2026journal-article

Cancers

Comprehensive Genomic Profiling Reveals the Mutational Spectrum and Clinical Significance of BRCA1/2 and Other Cancer-Susceptibility Genes in Breast Cancer Patients from Southern Tunisia

Nihel Ammous-Boukhris, Rania Abdelmaksoud-Dammak, Wala Ben Kridis, Dorra Ben-Ayed-Guerfali, Souhir Guidara, Ameni Feki, Hassen Kamoun, Afef Khanfir, Jamel Daoud, Gérard-Hubert Lizard, Ali Gargouri, Raja Mokdad-Gargouri

Background/Objectives: This study aims to investigate the mutational spectrum of BRCA1 and BRCA2 genes in a cohort of breast cancer (BC) patients from southern Tunisia, and to evaluate their clinical and prognostic significance. Additionally, this study explores the contribution of other cancer predisposition genes and the prevalence of variants of uncertain significance (VUS). Results: Among the 165 patients included, pathogenic or likely pathogenic variants (P/LPVs) in BRCA1/BRCA2 were identified in 19 cases (11. …

29.08.2026journal-article

Journal of Separation Science

Bridging the Gap Between Chemiluminescence Immunoassay and Liquid Chromatography‐Tandem Mass Spectrometry for Infliximab Monitoring: Method Validation and Clinical Comparability Study

Ying Xia, Ming‐Mei Zhu, Meng‐Qing Xiao, Chen‐Chun Zhong, Yu‐Jun Zhou, Yi‐Hao Xue, Shi‐Wei Zheng, Li Li, Feng Chen

ABSTRACT Infliximab (IFX) is a cornerstone biologic for pediatric inflammatory bowel disease, where therapeutic drug monitoring (TDM) is essential but complicated by inter‐platform variability. Systematic comparison of automated immunoassays with reference methods is therefore warranted. This study aimed to validate an in‐house chemiluminescence immunoassay (CLIA) for IFX quantification and evaluate its agreement with liquid chromatography‐tandem mass spectrometry (LC‐MS/MS). A CLIA kit was validated by assessing t …

29.08.2026journal-article

Journal of Clinical Medicine

Nocturnal Autonomic Dysregulation and Admission-Window Clinical Suicide-Risk Assessment in Hospitalized Children and Adolescents

Qiyuan Cao, Jiaqi Xu, Wenjing Li, Yan Zhang, Xuehua Huang, Kexin Zhou, Jinquan Zhang, Lijun Jiang

Background/Objectives: Suicide-risk assessment during child and adolescent psychiatric hospitalization draws on patient report, clinical history, and professional observation. Whether nocturnal autonomic physiology is concurrently associated with a structured admission-window assessment after accounting for depressive symptoms and self-reported suicidal ideation remains uncertain. Methods: We analyzed 212 hospitalized children and adolescents receiving inpatient care for a major depressive episode. All had a Nurses …

29.08.2026journal-article

Eurasian Journal of Anesthesiology and Intensive Care

Antibacterial effects of levobupivacaine against staphylococcus aureus in a patient-controlled epidural analgesia model: an in vitro experimental study

Gülay Akıncı

Aims: Catheter-related infections remain an important complication of epidural analgesia. Local anesthetics may contribute to infection prevention because of their antimicrobial properties. This study aimed to evaluate the antibacterial effects of clinically relevant concentrations of levobupivacaine against Staphylococcus aureus in a simulated patient-controlled epidural analgesia (PCEA) model. Methods: An in vitro experimental PCEA infusion system was established using epidural catheter tubing and 0.2-µm bacteria …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Neonatal Infectious Harm Reduction Benefits of Maternal Substance Use Treatment: A Dyad-Based Retrospective Review

Lindsey E Hastings, Ellen F Eaton, Rachel G Sinkey, Claudette L Poole

Abstract Background Substance use disorders (SUD) in pregnancy can disrupt routine prenatal care and have been linked to increased risk of congenital syphilis as well as perinatal exposure to hepatitis C (HCV) and human immunodeficiency virus (HIV). Moreover, inconsistent adherence to universal HCV maternal screening recommendations, fragmented care, and frequent removal of infants for child welfare often make timely identification of maternal HCV or syphilis infection challenging and follow-up screening of exposed …

29.08.2026journal-article

ACR Open Rheumatology

Reduction of CXCR3 + CCR6 + CD4 + T Cells and IL ‐17+ RORγt + CD4 + T Cells During Secukinumab Treatment Identifies Patients With Axial Spondyloarthritis Responsive to Subsequent Biologic Therapy

Addison Pacheco, Patricia Remalante‐Rayco, Nigil Haroon, Denis Poddubnyy, Robert D. Inman

Objective We recently reported an immune profile that stratifies patients with axial spondyloarthritis based on clinical response to secukinumab. We now undertake an exploratory study on the secukinumab nonresponder patients to determine if immunologic changes occur during their initial secukinumab treatment that could determine their next biologic response. Methods At the clinician's discretion, 18 patients who did not respond to secukinumab were either switched to a tumor necrosis factor inhibitor (TNFi; n = 8) o …