Gastroenterology Insights
Pancreato-Hepatobiliary Malignancies: A Comprehensive Narrative Review of Epidemiology, Diagnosis, Multimodal Management, the Evolving Systemic Therapy Landscape, and Survival
Pancreato-hepatobiliary (HPB) malignancies—pancreatic ductal adenocarcinoma (PDAC), hepatocellular carcinoma (HCC), and the biliary tract cancers (BTC) comprising intrahepatic, perihilar and distal cholangiocarcinoma, gallbladder carcinoma, and ampullary adenocarcinoma—together constitute one of the heaviest and fastest-growing burdens in global oncology. Liver cancer is the third leading cause of cancer death worldwide, and pancreatic cancer, with a mortality-to-incidence ratio approaching unity, is projected to b …