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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
12.08.2026journal-article

Journal of Dental Health and Oral Research

In-Office Clear Aligner Therapy in Orthodontics: A Systematic Review of Digital Workflows, Clinical Effectiveness and Cost-Efficiency

Amilkar Cárdenas

Objective: To systematically review and appraise the available evidence regarding the clinical effectiveness, digital workflows, manufacturing processes and cost-efficiency of in-office clear aligner therapy compared with commercially outsourced aligner systems and conventional fixed orthodontic appliances. Methods: A comprehensive literature search was conducted across PubMed, Scopus, Web of Science, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL) and Google Scholar for publications up to Marc …

12.08.2026journal-article

Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science

Conceptual design of walker-exoskeleton (WAL-EX) mechanism for gait rehabilitation and assistance

Fatih Cellek, Barış Kalaycioğlu

Hemiplegia is a neurological condition characterized by complete motor loss on one side of the body. This condition severely limits walking ability and daily functional independence. To restore walking function, gait rehabilitation becomes an essential part of the recovery process. Traditional gait rehabilitation usually requires close supervision by a therapist. This makes the process both labor-intensive and limited in accessibility. In response to these challenges, robotic and assistive technologies have been de …

12.08.2026journal-article

Stem Cell Research & Therapy

Efficacy and safety of haemopoietic stem cell transplant (HSCT) for mucopolysaccharidosis type I-Hurler syndrome (MPS-IH): a systematic review

Mubarak Patel, Karen Bean, Francis Pang, Miss Xiaoyu Tian, Miss Jiongyu Chen, Lisa Stirk, Nigel Armstrong

Abstract Background Mucopolysaccharidosis type I-Hurler’s (MPS-IH) is the most severe form of MPS-I, with onset in infancy, followed by rapid neurodegeneration, and death typically within the first decade in untreated patients. A previous systematic review (SR) concluded that treatment with allogeneic haematopoietic stem-cell transplant (allo-HSCT) offers a clear survival and neurocognitive advantage, but does not prevent residual somatic disease. That review was published 15 years ago, which implies a need for a n …

12.08.2026journal-article

Stem Cell Research & Therapy

Gestational age–associated differences in human umbilical cord mesenchymal stem cells: biological, paracrine, and neuroprotective properties

Xirui Peng, Yuhang Zhang, Yizhuo Li, Yangyang Cao, Lingling Zhang, Ju Wang, Xiaoli Zhang, Yiran Xu, Yu Yang, Jiajia Duan, Yuyang Yue, Juan Song, Changlian Zhu

Abstract Background Human umbilical cord mesenchymal stem cells (UCMSCs) have shown considerable therapeutic promise for neonatal brain injury. However, whether gestational age influences UCMSC biological characteristics and therapeutic efficacy remains unclear. This study investigated the potential functional and molecular differences between UCMSCs derived from preterm and full-term infants to inform future autologous and allogeneic cell-based therapies. Methods UCMSCs were isolated from full-term and preterm umb …

12.08.2026journal-article

Neuroprotection

Current status and future perspectives of platelet function‐guided precision antiplatelet therapy for patients with cerebral infarction

Guoliang Zhu, Xiaoling Chen, Xinyi Huang, Quandan Tan, Qing Cao, Yali Yang, Yapeng Lin, Jie Yang

Abstract Current evidence indicates that antiplatelet therapy as a cornerstone for secondary prevention of cerebral infarction. However, ischemic or bleeding events arising from antiplatelet drug resistance or excessive platelet inhibition can diminish its clinical benefit. These challenges have laid the foundation for individualized antiplatelet treatment. Although cytochrome P450 family 2 subfamily C member 19 ( CYP2C19 ) genetic polymorphisms have partially addressed the issue of drug resistance in these patient …

12.08.2026journal-article

Cancer Biome and Targeted Therapy

The Role and Mechanistic Effects of Gut Microbiota Metabolites in Immunotherapy for Hepatocellular Carcinoma

Yau-Tuen Chan, Pengde Lu, Jiaqi Zou, Zhuofeng Jiang, Lin Xu, Ning Wang

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced hepatocellular carcinoma (HCC), but low response rates and drug resistance remain major clinical challenges. Recent data underscore the gut-liver axis as a major determinant of therapeutic outcomes, particularly amid an epidemiological transition towards chronic liver diseases. In this review, we summarize the effects of gut microbiota-derived metabolites on the hepatic tumor immune microenvironment (TIME) and the efficacy of ICIs. Be …

12.08.2026journal-article

Human Factors and Ergonomics in Manufacturing & Service Industries

Occupational Accidents in Industrial Maintenance: A Systematic Review of Typologies and Causal Factors

Jonas Leonardo Gomes de Araújo, Ruan Eduardo Carneiro Lucas, Jader Morais Borges

ABSTRACT Industrial maintenance, as it involves direct contact with the internal components of machinery and equipment, entails a high level of exposure to occupational risks, requiring integrated analyses that correlate accident types, causal agents, and maintenance strategies. The aim of this study was to systematically map these associations, offering a fresh perspective on how specific maintenance strategies dictate accident causality. To this end, a systematic literature review (SLR) was conducted following th …

12.08.2026journal-article

Frontiers in Digital Health

Automatic analysis of speech representations to assess psychological distress

Sara Fernández-Velasco, Jose Moreno-Mesa, Daniel Escobar-Grisales, Diego M. Lopez, Juan Rafael Orozco-Arroyave

Background Current mental health diagnostic methods are limited by subjective clinical interpretation. Automatic speech analysis is a promising technology for objective assessment. Objective To evaluate and compare different speech-based representations (acoustic, phonetic, and time-frequency) and deep learning-based embeddings for discriminating symptoms associated with psychological distress. Methods A secondary analysis of the Distress Analysis Interview Corpus (DAIC-WOZ) was conducted using recordings from 125 …

12.08.2026journal-article

Nano Research

Ho-doped Prussian Blue for MR imaging-guided enhanced NIR-II photothermal-chemodynamic therapy via HSP70 inhibition against triple-negative breast cancer

Hao Liu, Wenzi Huang, Xinru Zhao, Chuanghuang Su, Peiyao Lin, Cheng Liu, Shun Fang, Jianxiong Lin, Mingyi Li, Huayong Liu, Shuai Han

Abstract Triple-negative breast cancer (TNBC) remains a challenging clinical challenge due to its chemoresistance, deep invasiveness, and thermal tolerance during photothermal therapy (PTT). Pristine Prussian Blue (PB) nanoparticles are limited by near-infrared I (NIR-I) absorption, weak nanozyme activity, and lack of imaging capability. Herein, we developed liposome-coated holmium-doped PB (HoPB@Lip) with an optimal Ho/Fe ratio of 0.4 as a multifunctional theranostic platform. Ho doping red-shifts the absorption t …

12.08.2026journal-article

American Journal of Physical Education and Health Science

Effects of Group-Based Cardiac Rehabilitation on Cardiopulmonary Endurance of Coronary Artery Bypass Graft Surgery Patients

Maria Haseen, Shehzad Waqar Sethi, Aiman Wahab, Hamad Ullah

Cardiac rehabilitation (CR) is an essential component of recovery following coronary artery bypass grafting (CABG). Group-based CR may provide outcomes comparable to conventional individual-based rehabilitation while improving resource utilization. To compare the effects of group-based and individual-based cardiac rehabilitation on functional capacity, health-related quality of life, physiological responses, and patient satisfaction following CABG surgery. This study is an RCT, with the sample size of 54 subjects i …

12.08.2026journal-article

Journal of Scientific Research and Reports

Occupational Stress and Work Burnout as Predictors of Safety Performance and Safety Behaviour in the Niger Delta Oil and Gas Industry

Odunze, Chimezie Edwin, Eucharia Oluchi Nwaichi, Ejikeme Ugwoha, Lazarus T. Sala

Occupational stress and work burnout may influence workers’ engagement in safe work practices and the safety performance of oil and gas organisations. This study investigated the impact of occupational stress and work burnout on the safety behaviour and safety performance of workers in oil and gas companies in the Niger Delta. A structured questionnaire was administered to 400 employees selected through random sampling, while the oil and gas companies were selected purposively. Data were analysed using SPSS version …

12.08.2026journal-article

Anaesthesia

Pain management after major oncological breast surgery: an updated systematic review and procedure specific postoperative pain management ( PROSPECT ) recommendations

Neel Desai, Dan S. Dirzu, Danaja Zolger, Desire N. Adansi, Marc Van de Velde, Girish P. Joshi, the PROSPECT Working Group of the European Society of Regional Anaesthesia and Pain Therapy

Summary Introduction Major oncological breast surgery can be associated with significant postoperative pain. The aim of this systematic review was to update existing recommendations for postoperative pain management after major oncological breast surgery. Methods A systematic review was undertaken following PROcedure SPECific postoperative pain managemenT (PROSPECT) methodology. Randomised controlled trials and systematic reviews that investigated peri‐operative analgesic, anaesthetic and surgical interventions wer …

12.08.2026journal-article

PRÁXIS EM SAÚDE

TECNOLOGIAS ASSISTIVAS NA REABILITAÇÃO COMUNICATIVA DE CRIANÇAS COM TEA

Beatriz Aguilar Pena, Érick Alessandro de Souza Rocha, Kessy Annie de Oliveira Saouza

O Transtorno do Espectro Autista (TEA) caracteriza-se por alterações significativas na comunicação, na interação social e no comportamento, impactando diretamente o desenvolvimento global e a autonomia dos indivíduos. Por sua complexidade, o TEA demanda uma intervenção estruturada e contínua, pautada na integração de diferentes áreas, a fim de favorecer a ampliação das habilidades comunicativas, sociais e cognitivas. A atuação multiprofissional é essencial para o desenvolvimento pleno das potencialidades e para a p …

12.08.2026journal-article

Annals of Surgical Oncology

Patterns of Lymph Node Metastases After Multimodality Therapy in Esophageal Carcinoma Treated with Robot-Assisted Minimally Invasive Esophagectomy (RAMIE)

Maxime E. Sanders, Eline de Groot, Robin B. den Boer, Jan Erik Freund, Nadia Haj Mohammad, Gert J. Meijer, Stella Mook, Jelle P. Ruurda, Richard van Hillegersberg

Abstract Background Lymph node metastases (LNMs) in esophageal carcinoma demonstrate extensive and variable dissemination. Previous mapping studies are limited to region-based reporting, heterogeneous classification systems, and absence of contemporary multimodality-treated cohorts. This study aimed to characterize the station-level distribution of LNMs after standardized robot-assisted minimally invasive transthoracic esophagectomy (RAMIE) with two-field lymphadenectomy and to evaluate patterns in relation to key …

12.08.2026journal-article

MP

ПРОГНОСТИЧЕСКИЕ ФАКТОРЫ ДОСТИЖЕНИЯ РЕМИССИИ У ПАЦИЕНТОВ С АКРОМЕГАЛИЕЙ НА ФОНЕ ТЕРАПИИ SANDOSTATIN LAR

Замира Халимова, Саодат Иссаева, Гавхар Жабборова

Актуальность. Акромегалия — редкое эндокринное заболевание, обусловленное хронической гиперсекрецией гормона роста (СТГ) и инсулиноподобного фактора роста-1 (ИФР-1) вследствие аденомы гипофиза. Аналоги соматостатина длительного действия, в частности Sandostatin LAR (октреотид), являются препаратами первой линии медикаментозного лечения, однако вариабельность клинического ответа на терапию существенна. Вопрос о факторах, определяющих вероятность и скорость достижения ремиссии, остаётся предметом активного научного п …

12.08.2026journal-article

Language, Speech, and Hearing Services in Schools

Spelling Errors of Monolingual English-Speaking Students and Spanish-Speaking Bilingual Learners

Michelle Torres-Chavarro, Kelly Farquharson, Carla Wood

Purpose: This study examined the types of spelling errors produced by typically developing bilingual learners (BLs) and monolingual English-speaking students and investigated whether students' vocabulary knowledge predicted the rate of spelling errors. Method: Writing samples were collected from 100 fifth-grade students (50 Spanish-speaking BLs and 50 monolingual English speakers) during an authentic classroom writing assessment. Spelling errors were coded based on English phonology, orthography, and morphology. A …

12.08.2026journal-article

Frontiers in Endocrinology

Combination olaparib and cyclophosphamide cancer therapy exacerbates ovarian reserve depletion in mice with conditional loss of Brca1 in oocytes

Yujie Cao, Zaahida Abdul Jalil, Xinyi Mu, Jessica M Stringer, Nadeen Zerafa, Amy L. Winship, Karla J. Hutt

Introduction Olaparib, a small-molecule poly(ADP-ribose) polymerase (PARP) inhibitor, selectively impairs single-strand DNA repair and improves outcomes in patients with BRCA1 -mutant cancers by promoting the accumulation of unrepaired DNA damage in tumor cells. It is increasingly used in combination with chemotherapy to enhance therapeutic efficacy and overcome resistance; however, its impact on ovarian function in BRCA1 mutation carriers remains unknown. Here, we investigated whether BRCA1 deficiency alters ovari …

12.08.2026journal-article

PRÁXIS EM SAÚDE

SERVIÇO ASSISTIDO POR ANIMAIS COMO ESTRATÉGIA CLÍNICA NO TRANSTORNO DO ESPECTRO AUTISTA

Kessy Annie de Oliveira Saouza, Érick Alessandro de Souza Rocha, Beatriz Aguilar Pena

Este relato de experiência descreve a inserção de cães co-terapeutas Nutella e Toddy (Labradores) e Charlotte (Jack Russell Terrier) em sessões de fonoterapia com 23 crianças diagnosticadas com Transtorno do Espectro Autista (TEA), sendo 20 do sexo masculino e 3 do feminino, em idade pré-escolar e escolar. As sessões ocorreram semanalmente, com duração de 40 minutos, durante 12 semanas. Foram aplicados os protocolos Protocolo de Observação Comportamental (PROC) e Avaliação do Desenvolvimento da Linguagem – 2 (ADL-2 …

12.08.2026journal-article

Frontiers in Microbiology

Skin-directed Solius UVB light therapy increases vitamin D levels and alters intestinal microbiome and metabolome homeostasis

Maira Jimenez-Sanchez, Hyungjun Yang, Ho Pan Sham, Zhiquan Clarence Huang, Jan P. Dutz, Bruce A. Vallance

The recent global rise in immune and inflammatory diseases, such as psoriasis and inflammatory bowel diseases, has been linked to Western society-based changes in lifestyle and environment. These include decreased exposure to sunlight in the ultraviolet B (UVB) spectrum, leading to impaired production of 25-hydroxyvitamin D. In addition, many of these diseases are linked to dysbiotic changes in gut microbiota composition and function. Clinical overlap between skin and gut diseases, along with growing evidence for a …

12.08.2026journal-article

Cancer Biome and Targeted Therapy

Oncogenic KRAS in Cancer Immunotherapy: From Oncogenic Signaling to Tumor-Immune Ecosystem Regulation

Milad Ashrafizadeh, Noushin Nabavi, Yifei Xu

KRAS mutations are among the most prevalent oncogenic drivers in human malignancies and are increasingly recognized as critical determinants of tumor progression, immune evasion, and therapeutic resistance. Beyond its canonical role in promoting oncogenic signaling, accumulating evidence indicates that KRAS functions as a regulator of the tumor immune microenvironment, influencing antigen presentation, inflammatory signaling, metabolic adaptation, stromal remodeling, and responsiveness to immunotherapy. This review …

12.08.2026journal-article

Nursing in Critical Care

Factors Influencing Unplanned Discontinuation of Continuous Renal Replacement Therapy: A Descriptive Time‐Series Analysis

Wanning Jia, Hongjiao Xu, Ruihan Peng, Haifeng Wang, Haitao Lu, Yingyi Bi

ABSTRACT Background Continuous renal replacement therapy (CRRT) is the preferred renal replacement therapy for critically ill patients with acute kidney injury; however, unplanned treatment discontinuation remains a major challenge that compromises treatment efficacy and patient outcomes. Aims To investigate the risk factors and temporal trends associated with unplanned CRRT discontinuation using descriptive time‐series analysis and to identify evidence‐based nursing interventions. Study Design This retrospective c …

12.08.2026journal-article

International Journal For Multidisciplinary Research

Biomass-Derived Nanocarbons for Antimicrobial Therapy: A Sustainable Pathway for Developing Health Infrastructure

Hezam Dhaif Allah

Nanocarbon-based drug delivery systems have gained increasing attention as advanced platforms for enhancing antimicrobial therapy, particularly in low-resource settings where drug resistance and limited healthcare infrastructure remain critical challenges. Among various nanocarbon materials, biomass-derived nanocarbon and carbon-based nanoparticles offer a unique combination of low-cost production, high surface area, tunable surface chemistry, and efficient drug loading capacity, making them especially suitable for …

12.08.2026journal-article

The Egyptian Journal of Otolaryngology

Adult aural rehabilitation practices among audiologists in India – a cross-sectional survey

Aparna Nandurkar

Abstract Background Adult hearing loss is a major global health concern. Adult aural rehabilitation (AR) is a comprehensive intervention that extends beyond hearing aid fitting to address communication, psychosocial well-being, and participation. Despite its recognized importance, information regarding adult AR practices among audiologists in India is limited. Objectives To investigate the current practices, service delivery models, assessment approaches, barriers, and perceptions related to adult AR among audiolog …