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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

European Heart Journal - Quality of Care and Clinical Outcomes

Cardiac rehabilitation programme accreditation and certification: Comparing international practices, mapping standards, benchmarks, and future directions – A scoping review

Lamees Abdullah Mohammed Ali, Asmaa El-Heneidy, Jenna Taylor, Julie Redfern, Robyn Gallagher, Dion Candelaria, Emma E Thomas

Abstract Aims Programme accreditation and certification are key mechanisms for standardising, assuring, and continuously improving the quality of cardiac rehabilitation. Comparative evidence on existing accreditation and certification schemes remains limited. This review compared these schemes to identify key characteristics, standards, convergences, divergences, implementation, and gaps to inform future quality improvement directions. Methods A scoping review following PRISMA-ScR guidelines was conducted searching …

24.08.2026journal-article

The American Journal of Chinese Medicine

Icariin: Unraveling Ferroptosis Mechanisms, Metabolic Networks, and Innovative Therapy Strategies

Xiaojiao Yang, Lijun Li, Jilin Wang, Longxiang Xie, Yuhan Chen, Jieying Wang, Xianbin You, Xiaoqin Ye

Ferroptosis is an iron-dependent form of cell death driven by lipid peroxidation. This concept reshapes our understanding of tissue degenerative lesions and oncogenesis. Icariin (ICA) is an isoprenyl flavonol glycoside derived from plants of the genus Epimedium. Acting as a bidirectional regulator of this pathway, it precisely modulates cellular sensitivity to ferroptosis across distinct disease states. This review systematically synthesizes literature from PubMed, ScienceDirect, Web of Science, and Google Scholar …

24.08.2026journal-article

Frontiers in Neurology

Group mindfulness-based cognitive therapy associated with reduced professional caregiver burden and improved quality of care in dementia: a multi-method study

Longyun Chen, Bencheng Wang, Ting Li, Nan Li, Xuanxuan Chen, Fei Liu, Tao Lv

Purpose To evaluate the association between an 8-week group Mindfulness-Based Cognitive Therapy (MBCT) program and changes in professional dementia caregiver burden, perceived stress, and patient neuropsychiatric symptoms. Methods This retrospective multi-method study included 94 professional dementia caregivers at a psychiatric hospital in China (intervention: n = 48; control: n = 46). The intervention group participated in an 8-week group MBCT program, while the control group received routine education. Caregiver …

24.08.2026journal-article

Frontiers in Cell and Developmental Biology

Crosstalk of regulated cell death pathways in sepsis-associated acute kidney injury: implications for therapy

Xi-Long Liu, Lei Ma

Sepsis-associated acute kidney injury (SA-AKI) is a common and severe complication in critically ill patients, independently associated with significantly increased mortality and a high risk of progression to chronic kidney disease. The pathogenesis of SA-AKI is complex and involves not only traditional concepts such as renal hypoperfusion, microcirculatory dysfunction, and direct tubular injury, but also, more importantly, the disordered activation of the host immune response. In recent years, regulated cell death …

24.08.2026journal-article

mBio

HMGB1-targeted anti-inflammatory rBox A gene therapy for viral airway infections and systemic inflammatory disease models

Kari Ann Shirey, Daniel Prantner, Lynda Coughlan, Chanhee Park, Lin Zou, Wei Chao, John Joseph, Jorge C. G. Blanco, Stefanie N. Vogel

ABSTRACT High mobility group box 1 (HMGB1) is a host-derived proinflammatory molecule released during cell injury. Elevated extracellular HMGB1 levels have been associated with disease severity. HMGB1 contributes to host influenza responses by stimulating TLR4/MD-2 signaling, amplifying lung inflammation, and tissue damage via cytokine production and leukocyte infiltration. HMGB1 also plays a central role in other inflammatory diseases, including sepsis and liver toxicity, making it both a biomarker of disease seve …

24.08.2026journal-article

Metabolites

The Statin Paradox: Drivers and Consequences of Therapy Discontinuation

Adrianna Dylik, Mikołaj Musiał, Michał Radke, Dominika Tuzimek, Dominika Rogoża, Bartosz Czekała, Anna Wawrzyniak, Nadzeya Zhuk, Katarzyna Skrypnik, Damian Skrypnik

Background: Statins are among the most frequently prescribed medications worldwide, with proven benefits in reducing all-cause and cardiovascular mortality, preventing major adverse cardiovascular events (MACEs), and lowering healthcare costs. Despite their well-established safety and effectiveness, discontinuation of statin therapy remains a common problem in both primary and secondary prevention. Methods: A systematic literature review was conducted in accordance with PRISMA guidelines and registered in the PROSP …

24.08.2026journal-article

Frontiers in Microbiology

Comparative efficacy and safety of vonoprazan-based dual therapy vs. bismuth-based quadruple therapy for Helicobacter pylori eradication: a GRADE-assessed systematic review and meta-analysis with trial sequential analysis

Alejandro Chen Liang, Yeison Cruz Castillo, Lorena M. Murrieta Bruciaga, Barbara Abreu Lopez, Salma Beltrán Covarrubias, Hector Jonan Flores Uribe, Vanessa Pamela Salolin-Vargas, Gabriela Flores Monar, José García-Corella, Ishaan Kalha, Ernesto Calderon Martinez

Background Helicobacter pylori infects approximately 4. 4 billion individuals worldwide, causing chronic gastritis, peptic ulcer disease, and gastric adenocarcinoma. The 2024 ACG guideline recommends bismuth-based quadruple therapy (BQT) as first-line treatment when susceptibility is unknown, while vonoprazan–amoxicillin (VA) dual therapy is conditionally endorsed as an alternative. Prior meta-analyses included vonoprazan-containing BQT control arms, introducing heterogeneity that may influence comparative efficacy …

24.08.2026journal-article

Frontiers in Pediatrics

Association between the timing of chewable complementary food introduction and functional speech disorders in children: a case-control study

Houbin Li, Guilian Huang, Qiang Qi

Objective To investigate the association between the timing of chewable complementary food introduction and functional speech disorders (FSD) in children, and to identify independent risk and protective factors with a primary focus on quantifying the effect of delayed chewable food introduction. Methods A case-control study was conducted including 90 children diagnosed with FSD and 90 healthy controls aged 2–8 years. Data were collected on demographic characteristics, electronic screen exposure, parent-child intera …

24.08.2026journal-article

PLOS One

Hybrid CNN-embedding fusion with MFCC-SVM for speech emotion recognition: Random vs actor-wise evaluation on CREMA-D

Parveen Kumari, Yogita Yashveer Raghav, Vimmi Kochher, Prashanth kumar katta, Abhilasha A, Prabhakar M, Jayanthiladevi A, Fikir Gizachew Belete

Speech Emotion Recognition (SER) is an important component of human-centered intelligent systems, yet robust performance remains challenging when speaker identities differ between training and testing. This study presents a protocol-aware and reproducible comparison on the CREMA-D corpus using three pipelines: (i) a classical MFCC-based Support Vector Machine (SVM), (ii) a log-mel Convolutional Neural Network (CNN), and (iii) a lightweight hybrid model that concatenates handcrafted acoustic descriptors with CNN-der …

24.08.2026journal-article

Journal of Human, Social and Political Science Research

CRITICAL DISCOURSE ANALYSIS OF PRESIDENT BOLA AHMED TINUBU'S INAUGURAL SPEECH IN NIGERIA

ADESOPE DAUDA ADESINA, AKINOLA OLAYODE JOHNSON

This paper presents a Critical Discourse Analysis (CDA) of the inaugural speech delivered by President Bola Ahmed Tinubu, the 17th President of Nigeria. The study employs Post-colonial Frantz Fanon (1961), and Fairclough's socio-cultural and socio-economic discourse approaches to CDA as a theoretical framework to explore power dynamic and discursive strategies utilized by the ruling elite. By examining President Tinubu's speech through the lens of post colonialism, this uncovered hidden ideologies, hegemonic practi …

24.08.2026journal-article

Journal of Endovascular Therapy

A Multicentre Experience of Inner-Branched Endovascular Aneurysm Repair for Treatment of Type Ia Endoleak After EVAR

Rens Jorn Oosterveld, Arjan W. J. Hoksbergen, Chrissy van Wely, Mathieu Lacquet, Lee H. Bouwman, Ozan Yazar

Purpose: To evaluate the outcomes of inner-branched endovascular aneurysm repair (iBEVAR) for the treatment of type Ia endoleak after infrarenal endovascular aneurysm repair (EVAR). Materials and Methods: This multicentre study retrospectively analyzed all consecutive patients who underwent elective revision using iBEVAR for type Ia endoleak after previous infrarenal EVAR. The primary outcome was technical success, and the secondary outcome was clinical success at 30 days. Outcomes during further follow-up were mor …

24.08.2026journal-article

Journal of Back and Musculoskeletal Rehabilitation

Prevalence of lower back pain among adults who drive in Saudi Arabia: Examining the influence of driving postures – A cross-sectional study

Mahmoud Mohammed Hassaan, Ali Fageeh, Alhassan H Hobani, Maryam Alamer, Alhanouf H Zuqayl, Huda Khudaish Muqri, Hatoon Yahya Zakari, Ryof M Madkhali, Rakan S Hazazi, Fawaz M Hakami, Naif Abualghaith, Maamon Aljonaid, Zenat A Khired

Background Low back pain (LBP) is a common health issue worldwide, affecting many people, and is expected to increase due to the aging population. This study explores the relationship between driving habits and LBP to inform interventions for driver well-being. Objective To determine the prevalence of lower back pain among adult drivers in Saudi Arabia and examine the association between driving postures and the occurrence of lower back pain. Methods A cross-sectional study was conducted in Saudi Arabia using a que …

24.08.2026journal-article

Frontiers in Neurology

Venous-phase Tan-based collateral assessment on CTP-derived CTA for outcome stratification after reperfusion therapy in acute ischemic stroke

Wei Zheng, Huiran Xu, Baoteng Zhang, Li Fu, Kaihe Lin, Suying Wu, Jianfang Huang, Lanying Zhu, Chongchong Dai, Xiaoyan Yu

Background Collateral status is closely related to functional outcome after reperfusion therapy in acute ischemic stroke. Conventional single-phase computed tomography angiography (CTA) Tan score may be affected by scan timing and delayed collateral filling, whereas CTA reconstructed from computed tomography perfusion (CTP) source images provides time-resolved vascular information. This study compared conventional CTA Tan score with time-specific Tan-based collateral scores on CTP-derived CTA for predicting 90-day …

24.08.2026journal-article

Galle Medical Journal

Delays in diagnosis and rehabilitation among children with cerebral palsy: A retrospective study from a tertiary care centre in Sri Lanka

S. A. C. Dalpatadu, S. Waidyanatha, P. D. Ratnayake, K. C. S. Dalpatadu

Introduction: Early identification of cerebral palsy is essential in receiving appropriate interventions, better patient outcomes, reducing the cost of rehabilitation. The aim of the study was to identify the delay in diagnosis and wait time for rehabilitation and factors associated with it. Methods: A retrospective descriptive cross-sectional study was conducted among 100 children with cerebral palsy attending rehabilitation services and neurology clinics at a leading tertiary children’s hospital in Sri Lanka. Con …

24.08.2026journal-article

Frontiers in Pharmacology

Dual MAO A and HSP90 inhibitors enhance anti-PD-1 therapy and suppress colorectal cancer

Hui-Ju Tseng, Yueh-Lin Wu, Yan-Ling Chen, Chien-Hua Wang, Suddhasatwa Banerjee, Jing-Ping Liou

Introduction Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, yet their efficacy remains limited by tumor resistance, immune-related adverse events, and poor response in microsatellite stable colorectal cancer (CRC). To address these challenges, dual monoamine oxidase A (MAO-A) and heat shock protein 90 (HSP90) inhibitors, MPT1B098 and MPT1B099, were developed and evaluated for their therapeutic potential and immune-modulatory efficacy in CRC. Methods Human and murine CRC cell lines were trea …

24.08.2026journal-article

American Journal of Speech-Language Pathology

“It's Hard Hard to Hard to Make It That Way. But You Gotta Make It All Different Levels”: Making Aphasia Groups Work From the Perspective of People With Severe Aphasia

Eleanor Gulick, Brent E. Archer

Purpose: Facilitators require further guidance on best practices to support people with severe aphasia (PWSA) who attend their aphasia groups. In this study, we position PWSA as experts who can inform future research and practice patterns. The aim of this study was to explore the ideas PWSA have regarding how aphasia groups should function with a specific focus on aspects that relate to meeting their needs, given the severity of their aphasia. Method: We analyzed data from interviews with five PWSA that were comple …

24.08.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

EFICÁCIA DA ELETROCONVULSOTERAPIA NA DEPRESSÃO REFRATÁRIA MEDICAMENTOSA: UMA REVISÃO DE LITERATURA

Paulo Peres Pimentel, Ramon Fraga de Souza Lima

RESUMO: A depressão refratária é um subtipo da depressão maior que não responde a pelo menos dois tratamentos com antidepressivos diferentes independente da classe medicamentosa, afetando uma parcela significativa dos pacientes com transtorno depressivo maior (TDM). A eletroconvulsoterapia (ECT) é considerada uma das melhores opções terapêuticas quando se trata de depressão refratária, sendo indicada como tratamento de primeira linha. Mesmo tendo um uso significativo nestes casos, seu mecanismo de ação ainda não é …

24.08.2026journal-article

Journal of Physical Therapy Education

An HSSBP-Guided Framework for an Interprofessional Virtual Reality Simulation-Based Learning Experience in Acute Care Physical Therapy Education

Gregory Brusola, Ryan Pontiff, Bruce Adcock, Rodney Welsh, Dana Wild

Background and Purpose: Advancements in health care education have emphasized the need for innovative, effective, and scalable educational tools. Virtual reality simulation-based learning experiences (VR SBLEs) offer immersive, repeatable training opportunities. However, many VR SBLE implementations lack framework-guided development, compromising replicability and educational rigor in physical therapist education. This article presents a systematic framework to develop and implement an interprofessional VR SBLE ali …

24.08.2026journal-article

Journal of Neuroscience

Functional distinctions between auditory cortex and frontoparietal network in the encoding of speech features

Yongtian Ou, Kendrick N. Kay, Andrew J. Oxenham

Neural representations of acoustic features that are key to speech perception have been studied extensively within the auditory cortex (AC), but their representations in higher-order cortical regions remain poorly understood. This study investigates the cortical encoding of three acoustic features in spoken vowels to delineate the functional distinctions across different cortical regions. We used ultra-high-field functional magnetic resonance imaging (fMRI) while human participants of both sexes listened to vowels …

24.08.2026journal-article

The FASEB Journal

Effect of Wearable Devices and 5G ‐Powered Remote Precision Rehabilitation on Vascular Function in Post‐ PCI Patients: An Analysis of the Associations Between FMS , Cardiorespiratory Fitness, and Arterial Stiffness

Yuping Long, Tao Xu, Zonghua Xiong, Xuan Fu, Zongyu Nie, Chengxia Zou, Hao Yu

ABSTRACT To explore the effects of personalized exercise prescriptions and 5G‐supported remote rehabilitation on adherence, lipid levels, cardiorespiratory fitness, and vascular function in patients after percutaneous coronary intervention (PCI), as well as to conduct a correlation analysis. This study employed a randomized, prospective clinical trial design, enrolling 155 patients at the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine from September 2024 to September 2025. Patients …

24.08.2026journal-article

Advanced Materials

Pathogen‐Mimetic Liposomes Customizing Protein Corona for Precision Glioblastoma Therapy

Xi Chen, Ying Wang, Xinyi Cai, Jingyu Zhao, Yong Ke, Shuangxiu Li, Yu Zhang, Fan Huang, Yang Liu, Shao‐Kai Sun, Zhanzhan Zhang

ABSTRACT Employing neutrophils (NEs) as endogenous moving gears offers a promising strategy for crossing the blood–brain barrier (BBB) in the treatment of central nervous system (CNS) malignancies such as glioblastoma (GBM). However, in vivo hitchhiking efficiency of NEs is severely limited by spontaneous formation of a nonspecific protein corona. Here, we present pathogen‐mimetic liposomes (PM‐Lipo) that enable efficient and precise NEs hitchhiking by programming the in vivo protein corona. PM‐Lipo is rationally e …

24.08.2026journal-article

Journal of Occupational & Environmental Medicine

A Bayesian Approach to Exposure Risk Characterization and Medical Surveillance Decision-Making in the U.S. Department of Energy

Ryan T. Cannady, Yeongjin Gwon, Cheryl Beseler, Steven Jahn, Matthew Nonnenmann

Objective: Apply Bayesian posterior probabilities to identify workers at high risk for elemental mercury exposure and optimize targeted industrial hygiene (IH) sampling and medical surveillance strategies. Methods: Bayesian modeling estimated probabilities of exceeding ACGIH, OSHA, and NIOSH occupational exposure limits. Posterior probability distributions for the 90th and 95th exposure percentiles were generated by job title and used to assign exposure-based risk bands that informed IH sampling frequencies and med …

24.08.2026journal-article

Frontiers in Medicine

Acute otitis media complicated by mastoiditis and otogenic transverse-sigmoid sinus thrombosis in an adult: a case report on infectious pathogenesis and multidisciplinary therapy

Fabián Darío Arias Rodríguez, Mercedes Larenas, María Roxana Gastañaga, María Eva Casal, Mónica Maya-Castro, Juan S. Izquierdo-Condoy

Background Acute otitis media is usually a self-limited bacterial infection; however, in rare cases, contiguous spread to the mastoid and adjacent dural venous sinuses may result in life-threatening intracranial complications. Otogenic transverse-sigmoid sinus thrombosis is uncommon in adults and represents a diagnostic and therapeutic challenge because its early presentation may be nonspecific and evidence guiding management remains limited. Case presentation We report the case of a 32-year-old man with no relevan …

24.08.2026journal-article

Revista Sustinere

Explorando o potencial do ChatGPT-3 como uma ferramenta para a tomada de decisões clínicas relacionadas a terapêutica medicamentosa em odontopediatria

Michelle Alonso Coutinho, Hislena Oliveira Ramos, Andréa Vaz Braga Pintor, Marcela Baraúna Magno

Avaliou-se o potencial do ChatGPT-3 como ferramenta clínica na terapêutica medicamentosa em odontopediatria, analisando a qualidade das respostas fornecidas. Foram feitas 45 perguntas sobre a forma terapêutica mais indicada (n=1), analgésicos (AN, n=17), anti-inflamatórios (AI, n=17) e anestésicos locais (AL, n=10) em diferentes cenários clínicos. As respostas foram analisadas quanto à precisão (0 a 5), completude (0 a 2), objetividade (0 a 2) e pontuação total (0 a 9). Os grupos de medicamentos foram comparado pel …