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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Critical Care & Emergency Medicine

Radiofrecuencia convencional y pulsada armonizada en el ganglio de Gasser para el tratamiento de la neuralgia del trigémino: resultados del protocolo Dolomedic

Francisco Javier Machuca Vigil, Rafael Orlando Vallejo Estrella, Roberto Jameson Rosales, Francesca Dolciami, Eduardo Perez Lozano

Objectives: To describe the experience with the Dolomedic protocol, which combines conventional radiofrequency (CRF) and harmonized pulsed radiofrequency (PRF) of the Gasserian ganglion, for the treatment of refractory trigeminal neuralgia. Material and Methods: A retrospective study was conducted in 77 patients with unilateral type 1 and 2 trigeminal neuralgia treated between July 2020 and July 2025 at Dolomedic Alta Especialidad (Heroica Matamoros, Mexico). The percutaneous approach to the Gasserian ganglion was …

28.08.2026journal-article

Medicine

Genetically proxied circulating PD-1/PD-L1 levels and broadly defined myocarditis

Fengyi Liu, Qian Yang

Myocarditis is an inflammatory myocardial disease with potentially severe outcomes. Programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) regulate immune tolerance, but the association between lifelong genetically proxied circulating PD-1/PD-L1 levels and broadly defined myocarditis remains uncertain. We investigated these associations and explored related plasma lipid species. We conducted bidirectional 2-sample Mendelian randomization using proteomic genome-wide association data from the UK …

28.08.2026journal-article

Medicine

Impact of an educational intervention on rational laboratory test ordering and healthcare costs in family medicine

Muhammet Şahinol, Hüseyin Nejat Küçükdağ

This study aims to analyze the impact of “Rational Laboratory Test Ordering” training given to family medicine residents on their test request habits, number of tests, and costs. A total of 27,085 applications made to the Family Medicine Polyclinic of Düzce University Faculty of Medicine between June 1, 2022, and June 1, 2024, were retrospectively examined. Based on the educational intervention provided to resident doctors on June 1, 2023, the periods before and after were compared in terms of the total number of t …

28.08.2026journal-article

Medicine

Temporal maintenance of an adolescent suicide attempt screening score in national surveys

Xiaotian Ma, Su Jia, Junjie Zhang

Screening scores may retain risk ranking while their probabilities become inaccurate in later populations. The information needed to repair this temporal drift is rarely quantified for adolescent suicide screening. We analyzed 5 independent national Youth Risk Behavior Survey cross sections from 2015 through 2023. Of 81,401 sampled students, 68,682 had observed past year attempt status. A survey weighted 2015 ridge score based on 14 harmonized predictors was frozen and transported to 4 later surveys. For each later …

28.08.2026journal-article

Acta Paediatrica

Trends in Childhood Underweight in Norwegian Children: Data From Routine Child Healthcare, 2010–2022

Sara‐Rebekka Færø Linde, Roy Miodini Nilsen, Mathieu Roelants, Melissa R. Balthasar, Jennifer L. Baker, Dorthe C. Pedersen, Boye Welde, Marjolein M. Iversen, Petur B. Juliusson, Anne‐Siri Fismen

ABSTRACT Aim This study examined age‐ and sex‐specific prevalence and trends in underweight among Norwegian children and adolescents during the pre‐pandemic period from 2010 to 2019 and COVID‐19 pandemic period from 2020 to 2022. Methods Height and weight data from 78 024 children aged 2 to 13 years in Bergen from 2010 to 2022 were obtained from public health clinic and school health service records. Underweight grades 1 to 3 were defined using the International Obesity Task Force cut‐offs. Age‐ and sex‐specific pr …

28.08.2026journal-article

Trials

Efficacy and safety of SP16 in preventing acute kidney injury in at-risk subjects with chronic kidney disease undergoing elective cardiac surgery using the heart–lung-machine (EASE-AKI): study protocol for a prospective, randomised, double-blind, placebo-controlled clinical trial

Tilman Jobst-Schwan, Karl Bihlmaier, Dana Austin, Cohava Gelber, Ann-Sophie Kaemmerer-Suleiman, Mathieu Suleiman, Robert Cesnjevar, Frank Harig, Mario Schiffer

Abstract Background Cardiac surgery using cardiopulmonary bypass uses controlled hypoperfusion which leads to relative organ damage. Acute kidney injury is the most frequent and most important organ failure, in particular in patients with chronic kidney disease. To date, there are no approved drug treatments that could effectively prevent acute kidney injury. SP16, an agonist of the low-density lipoprotein receptor-related protein 1, has been shown to exert both kidney- and cardioprotective effects in preclinical t …

28.08.2026journal-article

Frontiers in Public Health

A multicenter cross-sectional study on proactive health knowledge, attitude, and practice and its influencing factors among resident standardized training physicians in Guangxi

Qian Zeng, Jichen He, Kun Ye, Xuepeng Du, Jianzhen Chang, Qiaoying Wei, Shenglin Liang

Objective The purpose of this study is to examine the state of proactive health knowledge, attitude, and practice (KAP) among Guangxi’s resident standardized training physicians as well as the factors that affect it. The results will be used to optimize health management strategies. Methods A multicenter cross-sectional survey was conducted. Univariate analysis was used to compare differences in proactive health KAP among residents with different characteristics, and multivariate linear regression was performed to …

28.08.2026journal-article

Frontiers in Public Health

Patient perspectives on pain care pathways: informing implementation with insights from trial evidence

Lindsay A. Ballengee, Susan N. Hastings, Trevor A. Lentz, Katlin Harker, Steven Z. George

Background Few studies have examined whether patients' perceptions of low back pain (LBP) care pathways are influenced by evidence of their effectiveness. To inform future implementation efforts, we conducted an exploratory qualitative study examining how individuals with low back pain interpreted two pain care pathways that emphasized non-drug treatment options: a physical therapy–focused model (Sequenced Care Pathway) and a navigator-led model (Pain Navigator Pathway). We explored how individuals with low back pa …

28.08.2026journal-article

Frontiers in Endocrinology

The gamma-glutamyltransferase-to-estimated glomerular filtration rate composite index is associated with arterial stiffness: a cross-sectional secondary analysis of a health check-up population

Tengfei Gu, Guanghui Li, Gen Li, Pan Gao, Yang Su, Xiaoyang Li, Ziniu Zhao

Background Elevated gamma-glutamyltransferase (GGT), a marker of oxidative stress and cardiometabolic burden, and reduced estimated glomerular filtration rate (eGFR) are each linked to arterial stiffness, but they are usually examined separately. This study evaluated whether a single index integrating both—the GGT–eGFR composite index—is associated with brachial-ankle pulse wave velocity (baPWV). Methods This was a cross-sectional analysis of 893 adults from a Japanese health check-up program. The composite index w …

28.08.2026journal-article

Frontiers in Public Health

Associations between various obesity-related indicators and hypertension: a national cross-sectional survey with 117,609 Chinese adults

Chenglong Wang, Yini Wu, Mingjian Nie, Duobujie, Chenhui Xiao, Wanglong He, Chaoqun Fan, Qiang Feng, Jingjing Wang

Objective To evaluate how well obesity-related indicators (ORIs) discriminate hypertension in Chinese adults, thereby identifying the best-performing metrics and clarifying their dose–response associations with hypertension. Methods This study analyzed data from the 2020 National Physical Fitness Surveillance Database, comprising 117,609 adults aged 20–79 years with complete data on 10 ORIs and relevant covariates. Receiver Operating Characteristic (ROC) curves were employed to evaluate the discriminatory ability o …

28.08.2026journal-article

Molecular Medicine

Deletion of protein tyrosine phosphatase 1B in hepatocytes attenuates inflammation, steatosis, and fibrosis in a dietary mouse model of metabolic dysfunction-associated steatohepatitis

Ming-Fo Hsu, Yoshihiro Ito, Ulrik Mjaaseth, James Graham, Peter J. Havel, Fawaz G. Haj

Abstract Background Metabolic dysfunction-associated steatohepatitis (MASH) is a leading cause of liver-related morbidity and mortality. The current interventions are limited, underscoring the need for novel mechanism-based therapies. Protein tyrosine phosphatase 1B (PTP1B) regulates phosphotyrosine signaling and hepatic metabolism, but its role in MASH remains incompletely understood. Methods To elucidate the impact of modulating PTP1B expression in MASH, we used mice with hepatocyte-specific PTP1B disruption in t …

28.08.2026journal-article

Journal of Hospital Administration

Do state-level cultural competency educational mandates influence patient experience?

Mohammed Alzeen, Devdutt Upadhye, Rita DiLeo, Philip Cendoma, Kristine Hearld, Nancy Borkowski

Objective: We examined whether state cultural competency educational mandates are associated with patient-reported Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) scores. Methods: Analyzing data from 2018 and 2023 HCAHPS surveys, we compared state-level scores from 48 states and the District of Columbia (DC). Five states with cultural competency mandates (California, Connecticut, New Jersey, Oregon, Washington) were compared against five matched states and 38 remaining states with DC. Resu …

28.08.2026journal-article

Journal of Clinical Immunology

Preferential Retention of the LMP-1 Promoter at EBV Integration Sites in Lymphomas: Evidence from Cartilage Hair Hypoplasia and Controls

Zachery W. Dickson, Lari Pyöriä, Annika Kangas, Eetu Pello, Leo Hannolainen, Aino Mutka, Hanna-Leena Kukkola, Pasi Huttunen, Yossra H. S. Zidi-Mouaffak, Klaus Hedman, Mervi Taskinen, Panu E. Kovanen, Svetlana Vakkilainen, Maria F. Perdomo, Outi Mäkitie

Abstract Purpose Cartilage-Hair Hypoplasia (CHH), a rare ribosomopathy characterized by immune deficiency, carries a markedly increased risk of early-onset malignancy, particularly lymphoma. However, the molecular drivers of malignant transformation in CHH, and the contribution of viruses to this process, remain poorly defined. Methods We performed targeted virome sequencing of 41 DNA viruses on FFPE tumor samples (primarily lymphomas) from 15 CHH patients and three malignancy-matched controls per patient. Subseque …

28.08.2026journal-article

Frontiers in Public Health

Can long-term care insurance pilots promote urban industrial structure upgrading? Evidence from a quasi-natural experiment using the China Family Panel Studies

Jiyang Li, Liangyu Chen

Against the backdrop of population aging and rising demand for disability-related care, long-term care insurance (LTCI) not only shares household care risks but may also reshape urban economic structure by expanding formal care services. This study examines whether China’s LTCI pilots promote urban industrial structure upgrading and explores the associated transmission channels. Treating the staggered rollout of China’s LTCI pilots as a quasi-natural experiment, we match the 2014-2020 China Family Panel Studies wit …

28.08.2026journal-article

Public Health Journal

Model Prediksi Risiko Stunting Berbasis Faktor Ibu, Anak, dan Lingkungan pada Balita Usia 24–59 Bulan di Wilayah Kerja Puskesmas Pante Raja Kabupaten Pidie Jaya

Noeroel Arham, Safitria Safitria, Mika Sari, Selly Hidayanti, Siti Aminah

Stunting masih menjadi salah satu permasalahan kesehatan masyarakat yang utama di Indonesia karena berdampak terhadap pertumbuhan fisik, perkembangan kognitif, prestasi belajar, dan produktivitas pada masa dewasa. Meskipun berbagai penelitian telah mengidentifikasi faktor-faktor yang berhubungan dengan kejadian stunting, sebagian besar masih berfokus pada analisis hubungan antarvariabel tanpa menghasilkan model prediksi yang dapat dimanfaatkan sebagai alat skrining dini di pelayanan kesehatan primer. Penelitian ini …

28.08.2026journal-article

The Journal of Medicine, Law & Public Health

A Comparison of Patterns, Predictors, and Help-Seeking Behaviours Related to Intimate Partner Violence Among Women in Rural and Urban Communities of Osun State

Ojediran Joke Oluwatoyin, Onayade Adedeji, Olarewaju Sunday, Akinwale John Faniyi

Background: Intimate partner violence (IPV) is a major public health problem with serious physical, psychological, sexual, and socioeconomic consequences for women. This study compared patterns, predictors, and help-seeking behaviours related to IPV among women in rural and urban communities in Osun State, Nigeria. Methods: A comparative cross-sectional mixed-methods study was conducted between May and July 2023 among 500 ever-partnered women (250 rural and 250 urban) selected through multistage sampling. Quantitat …

28.08.2026journal-article

The Open Nursing Journal

Effectiveness of the Basic Infection Control Skills License (BICSL) Training Program on Nurses' Knowledge, Attitudes, and Practices in Makkah, Saudi Arabia

Azizah Banafi, Noor Mastura Mohd Mujar

Introduction Healthcare-associated infections (HCAIs) remain a major global health concern. In Saudi Arabia, the Basic Infection Control Skills License (BICSL) program was introduced to standardize infection prevention and control (IPC) training among healthcare workers. However, evidence on its effectiveness among nurses remains limited. Methods A multicenter, quasi-experimental, one-group pre-post study was conducted among 360 nurses from 5 public hospitals in Makkah, Saudi Arabia, during the 2024 BICSL implement …

28.08.2026journal-article

Health Research Journal of Indonesia

Gambaran Posttraumatic Growth (PTG) Pada Mahasiswa Kesehatan Universitas Negeri Gorontalo

Siti Hajar Salawali, Nanang Roswita, Anisa Zubaedi

Pendahuluan: Mahasiswa kesehatan berisiko mengalami berbagai peristiwa traumatis yang dapat memengaruhi kesehatan mental. Namun, tidak semua individu mengalami dampak negatif karena sebagian dapat mengalami Posttraumatic Growth (PTG), yaitu perubahan psikologis positif setelah menghadapi trauma. Tujuan: Penelitian ini bertujuan untuk mengetahui gambaran Posttraumatic Growth pada mahasiswa kesehatan Universitas Negeri Gorontalo. Metode: Penelitian menggunakan desain deskriptif kuantitatif. Sampel berjumlah 307 mahas …

28.08.2026journal-article

Child and Adolescent Psychiatry and Mental Health

Children referred as victims and alleged offenders for forensic psychiatric evaluation: distinct psychiatric profiles and machine-learning–based classification of post-traumatic stress disorder in a Turkish sample

Yasemin İmrek, Gökçe Koçak Çetin, Büşra Nur Kansu, Mesut Sari, Oya Kalaycioğlu, Ali Evren Tufan

Abstract Background Children referred for forensic psychiatric evaluation represent a heterogeneous and vulnerable population comprising both victims and alleged offenders, who may differ substantially in their psychopathological and cognitive characteristics. Evidence from non-Western legal and cultural contexts remains limited, and few studies have applied complementary classical and machine-learning approaches to identify factors associated with post-traumatic stress disorder (PTSD) in this group. This study aim …

28.08.2026journal-article

The Egyptian Journal of Internal Medicine

Exploring and understanding delirium: a comprehensive narrative review with emphasis on neurological disorders

Arpan mitra, Niraj Kumar Srivastava, ankur vivek, Nayana Bhuyan, Rukhsar Parveen, Vijaya Nath Mishra, Abhishek Pathak

Abstract A narrative review was presented, synthesizing existing literature on the historical understanding, neurobiological mechanisms, diagnostic approaches, and treatment modalities related to delirium. The purpose of this narrative review is to provide an updated overview of delirium, emphasizing its complex pathophysiology, clinical characteristics, risk factors, diagnostic challenges, and management strategies, particularly in patients with neurological disorders. Delirium predominantly occurs in hospitalized …

28.08.2026journal-article

International Journal of Social Sciences and Public Administration

Exploration on Practical Applications of Artificial Intelligence in the Field of Precision Oncology

Xinyu Meng

Precision oncology is a new model for cancer treatment that will no longer use traditional all-or-nothing methods but rather tailor treatments to specific changes in genes and other factors that cause cancer in different people. As the number of dimensions in biomedical data has been rising, more powerful computing facilities are needed to process such a large amount of data. Systematically explore the applications of artificial intelligence in the field of precision oncology in this paper. Research has been conduc …

28.08.2026journal-article

Journal of Primary Care Dentistry and Oral Health

Chairside Direct Fabrication of Cheek Plumpers on an Existing Complete Denture for Facial Esthetic Rehabilitation: A Clinical Case Report

Guddolla Venkata Prasanna, Karukayil Amrutha Mohanbabu, Vinnakota Dileep Nag

Abstract Esthetic rehabilitation in completely edentulous patients involves restoration of function and facial appearance. Loss of buccal fat, muscular tone, and alveolar bone support may result in sunken cheeks and compromised facial esthetics. Cheek plumpers support the facial musculature but are commonly incorporated during fabrication of new dentures; however, some patients may be unwilling to replace well-fitting existing prostheses. This clinical case report describes the conservative management of a patient …

28.08.2026journal-article

Statistics in Medicine

Penalized Cumulative Probability Model for a Continuous Outcome Subject to Detection Limits

Shuai Sun, Valeria R. Mas, Kellie J. Archer

ABSTRACT Mixed‐type outcome data occur when the outcome variable's distribution is a mixture of both continuous and discrete ordinal variables. Such mixed‐type outcomes are common in biomedical, psychological, and the health sciences, particularly for variables having either a detection or quantitation limit. When interest lies in identifying a combination of genomic features associated with a mixed‐type outcome, any method used would require a variable selection strategy for high‐dimensional data. Unfortunately, f …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Correction of facial skin aging signs using exosomes

T.N. Korolkova, I.A. Shepilova, T.G. Dovbeshko

Background. Skin aging is a multifactorial process caused by internal mechanisms and external influences. Gradual changes in the epidermis and dermis lead to impaired skin functions. Restoring these functions is an important task. Objective. Evaluation of the results of using a two-component complex with exosomes in patients with signs of facial skin aging. Material and methods. During this study, 22 patients (mean age 53.1±1.3 years) with Fitzpatrick skin phototypes I-III, wrinkles and other signs of facial aging …