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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
18.08.2026journal-article

Journal of Histochemistry & Cytochemistry

Immunocytochemical Localization of Neuronal Nitric Oxide Synthase (nNOS) in Neutrophils: Hydroxyurea Therapy Induced Nucleo-Cytoplasmic Translocation in Sickle Cell Disease

Rashmi Saini, Shilpy Shakya, Silvio Roberto Consonni

Sickle cell disease (SCD) is an inherited hemoglobinopathy leading to the deformability of red blood cells, enhanced cellular adhesion, and blockage in microcirculation. “Sickle Neutrophils” cause oxidative stress and decreased bioavailability of nitric oxide (NO) due to enhanced generation of reactive oxygen species (ROS). The mechanism of action of the common medication of SCD, hydroxyurea (HU), has not yet been thoroughly examined. This investigation examines the subcellular localization of neuronal nitric oxide …

18.08.2026journal-article

Virtual Communication and Social Networks

Adapting Musical Terminology to Virtual Communication: Musical Commentary as a New Speech Genre

Stepan Oreshkin

Songs, music videos, biographies of musicians, and music forums occupy a lot of virtual space. Internet users have to adapt musical terms to virtual communication, turning online musical commentary into a new speech genre. The author studied music-related texts, users’ comments, and video reviews in the Russian-speaking segment of the Internet to identify the processes of terminological adaptation and the genre specifics of music commentaries. Music-related terms undergo a deep transformation on the Internet. As a …

18.08.2026journal-article

Jurnal Keperawatan Profesional

Impact of Drawing Occupational Therapy on Auditory Hallucinations Among Mental Health Patients

Bunga Yusnanda, Milkhatun Milkhatun, Arief Budiman, Dwi Rahmah Fitriani

Auditory hallucinations are a common positive symptom of schizophrenia that can impair psychosocial functioning and increase the risk of aggressive behavior. Drawing-based occupational therapy has been proposed as a simple nonpharmacological intervention to help patients manage hallucinations. This study evaluated the implementation of drawing-based occupational therapy in reducing the severity of auditory hallucinations in a client with schizophrenia using a psychiatric nursing care approach. A single-case study w …

18.08.2026journal-article

ACS Applied Materials & Interfaces

Ultrasound-Activated Janus Heterojunction-Mediated Enhanced Cascade Nanozyme for Inflammatory Bowel Disease Therapy

Siyu Zhao, Jing Zhang, Xin Li, Yating Cui, Peng Cheng, Yunxiang Zhang, Xinmiao Hou, Derui Xu, Bolin Du, Qing Song, Ruijie Zhao, Xiaohui Wang, Peter R. Taylor, Xichuan Li, Xinghua Jin

Abstract Inflammatory bowel disease (IBD) is exacerbated by the excessive accumulation of reactive oxygen species (ROS). To overcome the insufficient catalytic activity of conventional cerium-based nanozymes, we designed an ultrasound-activated Bi@BTC heterojunction nanozyme. The ultrasound-activated carriers generated by bismuth core undergo effective electron-hole separation in the Janus Bi@BTC heterojunction. The holes are enriched in the valence band of the BTC shell, catalyzing the oxidation reaction of Ce3+. …

18.08.2026journal-article

BLACK SEA REGION AT THE CROSSROADS OF CIVILIZATIONS

ღორჯომის ხეობის მეტყველების ზოგიერთი ფონეტიკური თავისებურება

კაკალა ებრალიძე

დიალექტებში მოქმედ ენობრივ პროცესებზე დაკვირვება და მათი შესწავლა ენათმეცნიერებისათვის ყოველთვის საჭირო და სიახლისმომცემია. ხშირად დიალექტებში შემონა­ხუ­ლია ის, რაც სალიტერატურო ქართულში დავიწყებული ჩანს. ამ კუთხით განსაკუთრებული მნიშვნელობა ენიჭება დიალექტის ლოკალურ კვლევას, რომელიც დიალექტის ენობრივ თავი­სე­ბურებათა შედარებით სრულ სურათს წარმოაჩენს. ნაშრომში განხილულია ზემოაჭარული კილოკავის ერთ-ერთი საინტერესო და სახასიათო ხეობის - ღორჯომის მკვიდრთა მეტყველების ფონეტიკური თავისებურებები. კერძოდ, ბგერითი შედგენილო …

18.08.2026journal-article

BLACK SEA REGION AT THE CROSSROADS OF CIVILIZATIONS

ფილერები ფერეიდნელ ქართველთა მეტყველებაში

ეკა დადიანი, გიორგი მულიანი

ფერეიდნული დიალექტი, რომელიც ირანის ისლამურ რესპუბლიკაში, კერძოდ, ფერეიდუნშაჰრის პროვინციაში არის გავრცელებული, ენათმეცნიერთა განსაკუთრებული ინტერე­სის საგანია. ფერეიდნელ ქართველთა მეტყველება საინტერესოა ფილერების გამოყენების მხრივ. მეტყველების პროცესში ხშირად იხმარება სხვადასხვა ენობრივი საშუალებები: ნაცვალსახელები, შორისდებულები, ნაწილაკები, სიტყვები, ფრაზები, ბგერები / მარცვლები, პაუზა...). ფილერების მრავალფეროვნებასა და ინტენსივობას ძირითადად განსაზღვრავს ფერეიდანში არსებული ბი­ლინ­გვური გარემო და, შესაბამისად, …

18.08.2026journal-article

Physiotherapy Research International

Therapeutic Exercise Protocol During Hospitalization in Pediatric Oncohematological Patients: Randomized Clinical Trial

Cintia Freire Carniel, Bruna Cunha de Souza, Henrique Ferreira Leite, Juliana Zangirolami‐Raimundo, Rodrigo Daminello Raimundo

ABSTRACT Background Leukemias, lymphomas, and central nervous system tumors are among the most common pediatric cancers and may lead to motor deficits, impaired balance, reduced muscle strength, fatigue, and decreased functional capacity. Early physiotherapy during hospitalization may help prevent inactivity and support functional preservation in this population. Objective To evaluate the effects of a therapeutic exercise program on quality of life, muscle strength, fatigue, and functional capacity in hospitalized …

18.08.2026journal-article

Periódicos Brasil. Pesquisa Científica

Depression and Work Absence or Job Loss in Organizations

Paulo Henrique Andrade de Oliveira, Carlos Alberto Gonçalves, Luiz Osvaldo Vilar de Almeida De Almeida, Alexandre Dos Reis, Jennifer Michett

Recognized as one of the leading global causes of disability, depression broadly impairs emotional functioning, interpersonal relationships, and occupational performance, making it a phenomenon of increasing relevance within organizational contexts. Despite the growing body of scientific inquiry into the subject, integrative reviews that systematically address its multidimensional effects on working life remain scarce. Against this backdrop, the present study aimed to critically and comprehensively examine the psyc …

18.08.2026journal-article

Frontiers in Reproductive Health

Fertility counseling experiences and perceived gaps in provider support among people living with HIV: a qualitative study from an antiretroviral therapy clinic in Ghana

Victor Luckyboy Dzramado, Priscilla Asantewaa Boadi

Introduction Antiretroviral therapy (ART) has made safer childbearing achievable for people living with HIV (PLHIV), and the reproductive health counseling PLHIV receive within HIV care shapes whether they can act safely on their fertility intentions. This study explored, from the perspective of PLHIV themselves, how the reproductive counseling they reported receiving shaped their fertility decision making, and which aspects of counseling support they perceived to be missing. Methods A qualitative descriptive desig …

18.08.2026journal-article

Frontiers in Digital Health

Digitization of rehabilitation evaluation and activity monitoring using thermography: protocol for a mixed-methods randomized multiple baseline study in inpatient rehabilitation

Ravi Shankar, Karen Chua, Rathi Ratha Krishnan, Shuen-Loong Tham, Llewelyn Yi Chang Tan, Aletheia Lai, Megan Si En Lau, Zhi Kai Koh, Ernest Thia, Yating Su, Srinikethan Madapuzi Srinivasan, Poo Lee Ong

Background Patients in inpatient rehabilitation spend significant time of their day in sedentary activities, limiting recovery potential. Current monitoring relies on manual, intermittent nursing observations that are labor-intensive and produce fragmented data. Thermography-based artificial intelligence (AI) monitoring offers a privacy-preserving, continuous alternative; however, its impact on rehabilitation engagement when combined with patient-facing feedback has not been rigorously evaluated. Conventional pre-p …

18.08.2026journal-article

Stem Cells Translational Medicine

Exosome therapy for knee osteoarthritis: a network meta-analysis based on rat models

Yixiang Zhao, Haochuan You, Xiuyuan Wang, Xiping Dou, Jiangying Zhang, Yuzhe He, Lei Chen, Fei Huang, Yayi Xia

Abstract Objective To compare the therapeutic effects of exosomes from different cell sources and doses in rat knee osteoarthritis models using network meta-analysis, and to identify potential optimal strategies for preclinical optimization and clinical hypothesis generation. Methods A systematic search of PubMed, Web of Science, Embase, and Scopus identified 27 eligible randomized controlled trials (456 rats). Traditional random-effects meta-analysis and frequentist network meta-analysis were conducted. Treatments …

18.08.2026journal-article

JOSPT Open

Factors That Inform Clinical Reasoning for Therapeutic Exercise and Physical Activity Prescription in Musculoskeletal Physiotherapy: A Scoping Review of Qualitative Studies

Sarah Cooper, Chrystel Ghanem, Muhammet Yamali, James Anderson, Heather Gillis, Jessica J. Wong, Katie Kowalski

OBJECTIVE: To (1) identify factors informing physiotherapists’ clinical reasoning for therapeutic exercise and physical activity prescription in musculoskeletal populations, and (2) map these factors to the International Classification of Functioning, Disability and Health (ICF). DESIGN: Scoping review. LITERATURE SEARCH: Eight electronic databases and grey literature sources were searched from database inception to February 26, 2025. STUDY SELECTION CRITERIA: Qualitative studies examining physiotherapists’ clinica …

18.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Attitudes towards artificial intelligence among students and faculty staff at Kuwait University's Health Science Centre: A cross-sectional study

Hamad AlHamad, Ahmad Alenezi, Musaed Z. Alnaser, Dalal Almutairi, Fatemah AlObaid, Sara AlHarban, Sara AlRasheed

Background Artificial intelligence (AI) is increasingly integrated into healthcare and health-professions education. While it may improve efficiency, decision support, and learning, it also raises concerns about workforce impacts, safety, privacy, and accountability. Gulf-region evidence on how students and faculty perceive AI across disciplines within a single health science center remains limited. Objective To assess attitudes toward AI among health-sciences students and faculty and examine demographic factors as …

18.08.2026journal-article

Theoretical and Natural Science

A Literature Review of Recent Advances in Cell Therapy for Diabetes Mellitus

Ziqi Li

With the rising global prevalence of obesity and population aging, the number of patients with diabetes mellitus, a common chronic metabolic disorder, keeps rising and imposes mounting pressure on clinical medical services. Although current pharmacological interventions and insulin replacement therapy can effectively control blood glucose levels, they cannot fundamentally repair the functional defects of pancreatic islet β-cells, nor can they cure the disease. Under these circumstances, cell-based therapy has gradu …

18.08.2026journal-article

PAIN, JOINTS, SPINE

Assessment of Spirulina Gel Prepared by Different Extraction Methods as an Adjunctive Therapy to Mechanical Debridement in the Treatment of Stage II Periodontitis: A Randomized Clinical Trial

Faisal Mohammed M Alsharif, Nancy Hussein, Noha F. Ghazi, George Bebawy, Nermin Ali Mohamed Alamer, Mohamed Mahmoud Anees

Objective: To evaluate the clinical and biochemical effects of locally delivered spirulina gels prepared by different extraction methods as adjuncts to mechanical debridement in stage II periodontitis.Materials and methods: Seventy-five participants were included: 15 periodontally healthy negative controls and 60 participants with periodontitis who were randomized in a 1:1:1:1 ratio to the positive control, phosphate-buffered saline (PBS), 2% calcium chloride (CaCl₂), or ethanol groups (n=15 each). The clinical out …

18.08.2026journal-article

International Journal of Ophthalmology

Changes of pupil parameters and visual quality after cataract surgery as well as their correlation

Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China; NHC Key Laboratory of Myopia and Related Eye Diseases, Shanghai 200031, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, China, Fan Yang, Pei-Min Lin, Ming-Yang Wang, Department of Ophthalmology, Shanghai Tenth People’s Hospital, Shanghai 200072, China; Visual Rehabilitation Center, Tongji University School of Medicine, Shanghai 200072, China; Tongji Eye Institute, Tongji University School of Medicine, Shanghai 200072, China, Tian-Yu Zheng

AIM: To compare the changes of pupil parameters and visual quality after cataract surgery and explore their potential correlations. METHODS: This retrospective cohort study analyzed clinical data of Han Chinese patients who received cataract surgery from June 2016 to October 2016. Visual acuity, pupil size, pupil shift, wavefront aberrations, point spread function (PSF), and modulation transfer function (MTF) were detected preoperatively, 1d and 1mo postoperatively. Pupil parameters and visual outcomes were compare …

18.08.2026journal-article

Water

Influence of Natural Waters on the Leaching of Sewer Rehabilitation Resins

Konstantin Roman Ahrens, Reiner Gschwendtner, Anya Vollpracht

The leaching behavior of bisphenol A (BPA) remains a significant environmental concern. Despite EU regulatory restrictions and the World Health Organization (WHO) establishing precautionary values for human exposure to this monomer, BPA is still widely used in polymer-based products, including materials for sewer rehabilitation. Standard leaching assessments typically employ deionized water, although natural waters represent actual field conditions. This study investigates the release of BPA and its substitute, bis …

18.08.2026journal-article

Muscles, Ligaments and Tendons Journal

Rehabilitation Approaches After Meniscal Allograft Transplantation: A Systematic Review

Erva Nur Sagirli, Tugce Poyraz Isleyen

Purpose: This study aimed to (i) evaluate long-term outcomes after meniscal allograft transplantation (MAT), and (ii) review current rehabilitation protocols, including immobilization, weight-bearing, range of motion (ROM) progression, and return-to-sport timing. Methods: A systematic search of databases was conducted for articles published between January 2019 and April 2025 using the terms “meniscus transplantation OR meniscus allograft transplant” AND “rehabilitation OR physiotherapy OR physical therapy.” Result …

18.08.2026journal-article

Clinical Rehabilitation

Development and external validation of quality indicators for Neurorehabilitation Units: The REHABest Delphi study

Jacobo Formigo-Couceiro, Clara Pérez-Esteve, José María Climent-Barberá, Carlos Cordero-García, Raquel Cutillas-Ruiz, Esther Duarte, Francisco Javier Juan-García, María Lourdes López De Munaín, Rosa Martín-Mourelle, Antonio Montoto-Marqués, Serafín Rodríguez-Palero, Pedro Ignacio Tejada-Ezquerro, Emilio Ignacio-García, Helena Bascuñana-Ambrós

Objective To develop a consensus-based framework of quality indicators for Neurorehabilitation Units. Design Delphi consensus study with two-phase external validation. Setting Expert consultation and external validation were conducted through online questionnaires. Participants Twelve neurorehabilitation experts participated in the Delphi process. External validation involved 63 independent specialists and a multidisciplinary panel of nine professionals. Intervention Development of quality indicators through a thre …

18.08.2026journal-article

Multimedia Tools and Applications

Efficient speech denoising using CleanUNet optimized with Mamba and hybrid spectral loss

Matheus Vieira da Silva, João Fernando Mari, André Ricardo Backes

Abstract Speech enhancement aims to recover clean speech from signals degraded by noise and adverse acoustic conditions, such as background interference and echo. CleanUNet has emerged as an effective solution for causal speech denoising, but its high computational demands limit deployment on resource-constrained devices. In this work, we propose an optimized version of CleanUNet that significantly reduces model complexity while maintaining competitive performance. We replace the original Transformer bottleneck wit …

18.08.2026journal-article

Frontiers in Pharmacology

From toxicity to signal: positioning symptom clusters as pharmacodynamic indicators in ICI therapy

Yufang Ding, ChunWang Hua, Miao Rao, Cailin Ma, Qiuxia Zhong, Ping Gan, Guihua Hang

Immune checkpoint inhibitors (ICIs) have enhanced the treatment of cancer, but their clinical effect is usually limited by immune-related adverse events (irAEs). Currently, it is recognized that these toxicities are not merely common side effects. Rather, they are a set of complicated symptoms caused by different cytokine networks with different occurrences, progress and affected organ systems. Therefore, We propose that symptom assessment should not be limited to safety monitoring. Symptom complexes should be rega …

18.08.2026journal-article

ACS Applied Materials & Interfaces

Engineered Long-Acting Mild Hyperthermia Microneedle Patches for Personalized Therapy of Infected Diabetic Wounds

Xinmei Zhang, Miao Zhang, Fangyuan Li, Wenjie Yang, Haoyue Wang, Yuemin Wang, Jie Weng, Jianshu Li, Xingyu Chen

Abstract The clinical treatment of chronically infected wounds faces multiple challenges, including antibiotic resistance, imprecise thermal control, and frequent dressing changes that hinder healing. Herein, we developed a multifunctional mild hyperthermic microneedle patch (GPD-NAS@PDA MN) based on the reversible phase-transition characteristics of lower critical solution temperature (LCST) thermoresponsive polymers, enabling single-application administration and precise long-term temperature regulation. Under ne …

18.08.2026journal-article

Frontiers in Public Health

Exploring the occupational protection potential of an intravenous compounding robot across the cytotoxic drug workflow

Jing Sun, Bing Liu, Zhiqing Li, Ruoyu Hu, Shujuan Bai

Objective To evaluate an intravenous compounding robot's occupational protection across the full workflow (compounding, packaging, administration) by measuring cytotoxic drug residues, and to assess its cleaning protocol and cross-contamination risk for subsequent non-cytotoxic drug compounding. Methods (1)Questionnaire survey: Cytotoxic drug handlers at various workflow stages were surveyed for occupational protection and awareness. (2) Experimental study: Cyclophosphamide and fluorouracil were selected for a 3-da …

18.08.2026journal-article

Frontiers in Pharmacology

Case Report: Lorlatinib combined with chemotherapy and anti-angiogenic therapy shows promising efficacy in an ALK gene fusion lung adenocarcinoma patient with iruplinalkib resistance

Mengqing Cao, Shumin Li, Linfeng Cao, Feng Tao, Na Li

Background The Echinoderm microtubule-associated protein-like 4 (EML4) - Anaplastic lymphoma kinase (ALK) gene fusion represents a significant driver mutation in non-small cell lung cancer (NSCLC). Among the over 20 identified EML4-ALK variant subtypes, the V5' variant occurs relatively infrequently, constituting merely 4% of cases. Currently, the clinicopathological features and prognostic implications associated with this particular variant remain poorly characterized in the literature. Case summary We report the …